Meniscus Body Position, Size, and Shape in Persons With and Persons Without Radiographic Knee Osteoarthritis: Quantitative Analyses of Knee Magnetic Resonance Images From the Osteoarthritis Initiative

Abstract

Our findings indicate altered meniscal position and shape (i.e., more bulging) in both compartments in medial compartment knee OA. These changes may be important features of OA pathogenesis and/or disease consequences.

Baseline meniscal extrusion associated with incident knee osteoarthritis after 30 months in overweight and obese women

“…Still, our data confirm that medial body extrusion is more strongly associated with incident knee OA than any other location, which, to save time and costs, supports the choice for one sole measurement location in previous and future studies. The vast majority of the meniscal extrusions were located in the medial meniscus, especially in the body (71%), which corresponds to previous findings 6,9 . The difference seen in our study however is slightly Meniscal tears and cartilage damage however are both largely non-modifiable risk factors.…”

“…Several recent studies described a new approach for quantitative MRI analysis of meniscal extrusion using 3D imaging techniques 9,10 , which might be a more reliable way to assess volumetric morphometry and extrusion of the meniscus and a more truthful representation of the in vivo situation.…”

“…The generally accepted idea is that a displaced meniscus affects the weight-bearing and load distribution capacities within the knee joint, which leads to loss of cartilage and increase in bone marrow lesions, ultimately resulting in knee OA [6][7][8] . Multiple studies affirm this relationship between meniscal extrusion and the development of knee OA or features thereof [6][7][8][9][10] . However, most of these studies were carried out in cohorts of subjects with established OA.…”

Automated Image Analysis of High-field and Dynamic Musculoskeletal MRI

“…In the study, they compared the reproducibility of analyses in 2D IW-TSE ( , Blöcker 2013, Wenger 2013.…”

“…New developments in quantitative magnetic resonance (MR) imaging have generated considerable clinical interest for the design of methods to study the morphology and biochemical composition of the medial meniscus (MM), lateral meniscus (LM) and PCL in relation to knee injuries and OA [Wirth 2010, Wenger 2013, as well as for the assessment of in-vivo 3D knee kinematics using dynamic MR imaging (e.g., contact mechanisms between cartilages [Borotikar 2012]). These measurements offer avenues to study early pathophysiological changes associated with pre-osteoarthritic degeneration (e.g., reorganisation of the extracellular matrix of the meniscus affecting normal function [Juras 2014, Zarins 2010); assess the structural integrity of the menisci and ligaments post-surgery (e.g., healing properties of the tissues [Chu 2014, Biercevicz 2014a); or investigate abnormal bone tracking or contact mechanisms in PFPS [Pal 2013] or in ligament-deficient patients [Barrance 2006] for predicting subsequent risks of cartilage wear.…”