Meniscus Allograft Survival in Patients with Moderate to Severe Unicompartmental Arthritis: A 2- to 7-Year Follow-up

Stone, Kevin R.; Walgenbach, Ann W.; Turek, Thomas J.; Freyer, Abhi; Hill, Martin D.

doi:10.1016/j.arthro.2005.12.045

Cited by 84 publications

(50 citation statements)

References 13 publications

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“…2,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] These data indicate that meniscus substitution by an allograft is feasible, safe, and reliable. Comparative clinical studies including an untreated control group are however unavailable in the literature and therefore, chondroprotection by meniscus substitution using an allograft remains unproven.…”

Section: Discussionmentioning

confidence: 98%

“…More recent studies have not confirmed a significant correlation between the initial cartilage status and clinical failure, challenging the contraindications for arthrosis severity. 8,20 Radiologic Outcome…”

Section: Clinical Outcomementioning

confidence: 99%

“…8 In general, articular cartilage lesions greater than grade 3 according to the ICRS classification system should be of limited surface area and localized. Localized chondral defects may be treated concomitantly-the meniscus transplant and the cartilage repair or restoration may benefit each other in terms of healing and outcome.…”

Section: Contraindications To Meniscal Allograft Transplantationmentioning

confidence: 99%

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Meniscal Allografts: Indications and Outcomes

Verdonk

Almqvist

Huysse³

et al. 2007

Sports Medicine and Arthroscopy Review

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Meniscal allograft transplantation was introduced into clinical practice now over 20 years ago for the treatment of the symptomatic postmeniscectomy patient who has not yet developed osteoarthritis. Over the years, the indications have been fine-tuned and certain risk factors for failure have been identified. As the number of publications increases steadily, we now know that meniscal allografting significantly reduces pain and improves function. Recent data also suggest a potential chondroprotective effect in a subpopulation of patients. However, the major drawback in all meniscus allograft studies is the general lack of a control population. To improve our knowledge, future prospective studies should include objective outcome tools to evaluate the status of the allograft in addition to the clinical scoring systems. Future research should focus to elucidate the biologic and cellular processes involved in graft repopulation and remodelation.

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Section: Discussionmentioning

confidence: 98%

Section: Clinical Outcomementioning

confidence: 99%

Section: Contraindications To Meniscal Allograft Transplantationmentioning

confidence: 99%

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Meniscal Allografts: Indications and Outcomes

Verdonk

Almqvist

Huysse³

et al. 2007

Sports Medicine and Arthroscopy Review

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“…[5][6][7][8][9][10] Rue et al 5 reported on 31 combined procedures of meniscal allograft transplantation and cartilage restoration with a minimum two-year follow-up and an overall success rate of 93% at a mean of 3.1 years. Farr et al 7 described 29 combined meniscal allograft transplantation and autologous chondrocyte implantation with an overall success rate of 86% at a mean of 4.5 years.…”

mentioning

confidence: 98%

Long-term survival of concurrent meniscus allograft transplantation and repair of the articular cartilage

Stone

Adelson²,

Pelsis³

et al. 2010

The Journal of Bone and Joint Surgery. British volume

108

153

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We describe 119 meniscal allograft transplantations performed concurrently with articular cartilage repair in 115 patients with severe articular cartilage damage. In all, 53 (46.1%) of the patients were over the age of 50 at the time of surgery. The mean follow-up was for 5.8 years (2 months to 12.3 years), with 25 procedures (20.1%) failing at a mean of 4.6 years (2 months to 10.4 years). Of these, 18 progressed to knee replacement at a mean of 5.1 years (1.3 to 10.4). The Kaplan-Meier estimated mean survival time for the whole series was 9.9 years (sd 0.4). Cox's proportional hazards model was used to assess the effect of covariates on survival, with age at the time of surgery (p = 0.026) and number of previous operations (p = 0.006) found to be significant. The survival of the transplant was not affected by gender, the severity of cartilage damage, axial alignment, the degree of narrowing of the joint space or medial versus lateral allograft transplantation. Patients experienced significant improvements at all periods of follow-up in subjective outcome measures of pain, activity and function (all p-values < 0.05), with the exception of the seven-year Tegner index score (p = 0.076).

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“…Several authors [32,34] have suggested incorporating donor gender, height, and weight as variables to improve allograft matching. In addition, other authors have suggested that allograft tissue from donors under age 45 is acceptable for transplantation [5].…”

Section: Allograft Sizing and Matchingmentioning

confidence: 99%

Meniscus transplantation

Frank

Cole

2015

Curr Rev Musculoskelet Med

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Understanding the structure and function of the meniscus is critical to understanding its role in overall knee joint function. Injury to, or removal of, meniscal tissue may be associated with articular cartilage wear, knee instability, and, ultimately, the progression of osteoarthritis. While every effort is made for preserving and/or repairing damaged meniscal tissue, in some cases, the meniscus is not amenable to repair after injury. For appropriately indicated patients with symptomatic meniscal deficiency, meniscus allograft transplantation is an excellent surgical solution aimed at reducing pain and improving function. Indications for meniscus allograft transplantation are limited, and concomitant procedures such as osteotomy for malalignment, ligamentous, and/or articular cartilage restoration may be necessary in order to ensure an optimal result following meniscus allograft transplantation. Surgical techniques for meniscus allograft transplantation are variable and include soft-tissue fixation versus bone plug fixation versus bone bridge fixation. Outcomes following meniscus allograft transplantation are generally good to excellent, though reoperation rates are relatively high. The purpose of this article is to provide a concise review of recently published data on meniscus allograft transplantation, with a focus on recent outcomes studies.

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Meniscus Allograft Survival in Patients with Moderate to Severe Unicompartmental Arthritis: A 2- to 7-Year Follow-up

Cited by 84 publications

References 13 publications

Meniscal Allografts: Indications and Outcomes

Meniscal Allografts: Indications and Outcomes

Long-term survival of concurrent meniscus allograft transplantation and repair of the articular cartilage

Meniscus transplantation

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