Meniscal repair by synovial flap transfer: Healing of the avascular zone in rabbits

Cisa, Jordi; Basora, Jorge; Madamas, Prometeo; Ghibely, Andre; Navarro-Quilis, Antonio

doi:10.3109/17453679508994636

Cited by 36 publications

(23 citation statements)

References 11 publications

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“…The current study revealed that one of the important cytokine effects caused by synovial MSCs was the induction of synovial tissue to the meniscal lesion or the formation of synovial tissue in the meniscal lesion. A number of papers have provided support for the importance of this induction of synovial tissue to the meniscal lesion for meniscal healing 7,8 .…”

Section: Discussionmentioning

confidence: 98%

Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs

Nakagawa

Muneta

Kondo

et al. 2015

Osteoarthritis and Cartilage

112

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Section: Discussionmentioning

confidence: 98%

Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs

Nakagawa

Muneta

Kondo

et al. 2015

Osteoarthritis and Cartilage

112

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“…Cisa et al 74 published good results in rabbits after using synovial flaps. Kobuna et al 75 using microangiography in dogs, demonstrated that vessels located on the femoral surface and the inner part of the meniscus reached the sutured area after 6 weeks, and showed healing with a fibrovascular tissue.…”

Section: Techniques Associated With Sutures To Stimulate Meniscal Repairmentioning

confidence: 92%

Meniscus tear surgery and meniscus replacement

Vaquero

Forriol

2016

MLTJ

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SummaryObjective: the menisci are easily injured and difficult to repair. The aim of this study was to analyze the current state of meniscal surgery aimed at preserving morphology and conserving the biomechanics of the knee to prevent joint degeneration. Methodology: a search of the electronic medical literature database Medline was conducted, from http://www.ncbi.nlm.nih.gov/pubmed. The search was not limited by language. Candidate articles were identified by searching for those that included the keywords meniscus, surgery, suture, implant, allograft. The limits were included for clinical research and clinical trials. Basic research was not included. The studies selected were evaluated and classified in three different categories: basic science, reconstruction (suture and meniscectomy) and implants (scaffolds and allograft). Results: the consequences of meniscectomy performed at a young age can lead to a joint cartilage degeneration twenty years later. There are few surgical options for the repair of meniscal injuries in order both to preserve the meniscus and to ensure the long term survival of the knee joint, meniscectomy, repair, suturing the tear, or reconstruction, when a meniscal allograft or synthetic substitute is used to replace the meniscus, but the biomechanical properties of the native meniscus are not reproduced entirely by the scaffolds that exist today.Conclusion: therapies that successfully repair or replace the meniscus are therefore likely to prevent or delay osteoarthritis progression.

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“…In vivo, canine osteoarthritic joint- origin synoviocytes are responsible for cellular repopulation of meniscal grafts [29] and undergo spontaneous fibrochondrogenesis [30], including formation of a meniscal-like regenerate in meniscectomized stifles [31]. Synovial pedicle grafts and free synovial grafts have been used to achieve partial avascular meniscal healing in dogs and rabbits [32-35] and are superior to muscle flaps and synthetic meshes in dogs [33]. Use of living, autologous bioscaffolds with these regenerative properties could be advantageous over use of synthetic scaffolds for augmenting meniscal healing or treating meniscal loss.…”

Section: Introductionmentioning

confidence: 99%

In vitro synthesis of tensioned synoviocyte bioscaffolds for meniscal fibrocartilage tissue engineering

et al. 2013

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BackgroundMeniscal injury is a common cause of lameness in the dog. Tissue engineered bioscaffolds may be a treatment option for meniscal incompetency, and ideally would possess meniscus- like extracellular matrix (ECM) and withstand meniscal tensile hoop strains. Synovium may be a useful cell source for meniscal tissue engineering because of its natural role in meniscal deficiency and its in vitro chondrogenic potential. The objective of this study is to compare meniscal -like extracellular matrix content of hyperconfluent synoviocyte cell sheets (“HCS”) and hyperconfluent synoviocyte sheets which have been tensioned over wire hoops (tensioned synoviocyte bioscaffolds, “TSB”) and cultured for 1 month.ResultsLong term culture with tension resulted in higher GAG concentration, higher chondrogenic index, higher collagen concentration, and type II collagen immunoreactivity in TSB versus HCS. Both HCS and TSB were immunoreactive for type I collagen, however, HCS had mild, patchy intracellular immunoreactivity while TSB had diffuse moderate immunoreactivity over the entire bisocaffold. The tissue architecture was markedly different between TSB and HCS, with TSB containing collagen organized in bands and sheets. Both HCS and TSB expressed alpha smooth muscle actin and displayed active contractile behavior. Double stranded DNA content was not different between TSB and HCS, while cell viability decreased in TSB.ConclusionsLong term culture of synoviocytes with tension improved meniscal- like extra cellular matrix components, specifically, the total collagen content, including type I and II collagen, and increased GAG content relative to HCS. Future research is warranted to investigate the potential of TSB for meniscal tissue engineering.

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Meniscal repair by synovial flap transfer: Healing of the avascular zone in rabbits

Cited by 36 publications

References 11 publications

Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs

Synovial mesenchymal stem cells promote healing after meniscal repair in microminipigs

Meniscus tear surgery and meniscus replacement

In vitro synthesis of tensioned synoviocyte bioscaffolds for meniscal fibrocartilage tissue engineering

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