Meniscal regeneration with copolymeric collagen scaffolds

Stone, Kevin R.; Rodkey, William G.; Webber, Richard J.; MCKINNEY, L.; Steadman, J. Richard

doi:10.1177/036354659202000202

Cited by 220 publications

(51 citation statements)

References 14 publications

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“…However, issues with these grafts include donor availability, size matching, disease transmission, incomplete cellular incorporation post-surgery, and poor integration to the surrounding tissues (Greis, et al, 2002). In order to overcome these limitations, a number of tissue engineered (TE) constructs and scaffolds have been developed to replace portions of the damaged meniscus (Aufderheide, et al, 2007, Ballyns, et al, 2011, Cook, et al, 2006, Heijkants, et al, 2004, Kelly, et al, 2007, Mandal, et al, 2012, Stone, et al, 1992, Veth, et al, 1986). An increasing number of these engineered materials have focused on matching macroand micro-structural features of native tissue that enable its complex load bearing function.…”

Section: Introductionmentioning

confidence: 99%

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

Fisher

Henning

Söegaard

et al. 2015

Journal of Biomechanics

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Despite advances in tissue engineering for the knee meniscus, it remains a challenge to match the complex macroscopic and microscopic structural features of native tissue, including the circumferentially and radially aligned collagen bundles essential for mechanical function. To mimic this structural hierarchy, this study developed multi-lamellar mesenchymal stem cell (MSC)-seeded nanofibrous constructs. Bovine MSCs were seeded onto nanofibrous scaffolds comprised of poly(ε-caprolactone) with fibers aligned in a single direction (0° or 90° to the scaffold long axis) or circumferentially aligned (C). Multi-layer groups (0°/0°/0°, 90°/90°/90°, 0°/90°/0°, 90°/0°/90°, and C/C/C) were created and cultured for a total of 6 weeks under conditions favoring fibrocartilaginous tissue formation. Tensile testing showed that 0° and C single layer constructs had stiffness values several fold higher than 90° constructs. For multi-layer groups, the stiffness of 0°/0°/0° constructs was higher than all other groups, while 90°/90°/90° constructs had the lowest values. Data for collagen content showed a general positive interactive effect for multi-layers relative to single layer constructs, while a positive interaction for stiffness was found only for the C/C/C group. Collagen content and cell infiltration occurred independent of scaffold alignment, and newly formed collagenous matrix followed the scaffold fiber direction. Structural hierarchies within multi-lamellar constructs dictated biomechanical properties, and only the C/C/C constructs with non-orthogonal alignment within layers featured positive mechanical reinforcement as a consequence of the layered construction. These multi-layer constructs may serve as functional substitutes for the meniscus as well as test beds to understand the complex mechanical principles that enable meniscus function.

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Section: Introductionmentioning

confidence: 99%

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

Fisher

Henning

Söegaard

et al. 2015

Journal of Biomechanics

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“…Studies involving the replacement of meniscal disc 19 and TMJ disc 5 using collagen have reported a decrease in degenerative changes. These reports led to the current design of biodegradable reconstituted collagen template implant material for the regeneration of the TMJ disc 14 .…”

mentioning

confidence: 99%

Histological analysis of regeneration of temporomandibular joint discs in rabbits by using a reconstituted collagen template

Lai¹,

Tsai²,

Su³

et al. 2005

International Journal of Oral and Maxillofacial Surgery

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“…Different types of meniscal substitutes, such as autologous tissue 81–83 , decellularized allogenic and xenogenic grafts 76,84,85 , collagen grafts 86 , permanent synthetic scaffolds 38 , silk fibroin scaffolds 87,88 , and biodegradable scaffolds based on small intestine submucosa 89 , poly-lactic acid (PLA) or poly-glycolic acid (PGA) 90,91 , have been used in experimental and clinical studies.…”

Section: Strategies To Improve Meniscal Repairmentioning

confidence: 99%

Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus

Cucchiarini

McNulty

Mauck

et al. 2016

Osteoarthritis and Cartilage

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SUMMARY Meniscal lesions are common problems in orthopaedic surgery and sports medicine, and injury or loss of the meniscus accelerates the onset of knee osteoarthritis. Despite a variety of therapeutic options in the clinics, there is a critical need for improved treatments to enhance meniscal repair. In this regard, combining gene-, cell-, and tissue engineering-based approaches is an attractive strategy to generate novel, effective therapies to treat meniscal lesions. In the present work, we provide an overview of the tools currently available to improve meniscal repair and discuss the progress and remaining challenges for potential future translation in patients.

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Meniscal regeneration with copolymeric collagen scaffolds

Cited by 220 publications

References 14 publications

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

Engineering meniscus structure and function via multi-layered mesenchymal stem cell-seeded nanofibrous scaffolds

Histological analysis of regeneration of temporomandibular joint discs in rabbits by using a reconstituted collagen template

Advances in combining gene therapy with cell and tissue engineering-based approaches to enhance healing of the meniscus

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