Meniscal allograft transplantation: a review of indications, techniques, and outcomes

Cavendish, Parker A.; DiBartola, Alex C.; Everhart, Joshua S.; Kuzma, Scott A.; Kim, Walter J.; Flanigan, David C.

doi:10.1007/s00167-020-06058-6

Cited by 39 publications

(41 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6 KOOS4 was used as the primary outcome measure (excluding KOOS Activities of Daily living), as it is well-established in this group of patients, and allows one summary score for analysis. [3][4][5] additionally, ProMs after Mat have been shown to be preserved for at least seven years. 7 Analysis of each of the five subdomains of KOOS was also performed.…”

Section: Methodsmentioning

confidence: 96%

“…KOOS subdomains and KOOS4 range from 0 (worst) to 100 (best), with a minimal important change reported from 8 to 10. [3][4][5][6] Statistical analysis. Baseline demographic data are displayed with means and standard deviations (sDs) for normally distributed data, and medians and interquartile ranges (iQrs) for non-normally distributed data.…”

Section: Methodsmentioning

confidence: 99%

“…3 Multiple case series have been reported detailing the outcome in terms of failure and patient-reported outcome measures (ProMs), identifying factors correlated with better or worse outcome. [3][4][5] With no national registries established for Mat, factors related to outcome are predominantly confined to individual case series with small sample sizes, or secondary systematic reviews, and meta-analyses. [3][4][5] this paper reports the outcome from 526 patients who received Mat as part of an international cohort.…”

Section: Introductionmentioning

confidence: 99%

“…[3][4][5] With no national registries established for Mat, factors related to outcome are predominantly confined to individual case series with small sample sizes, or secondary systematic reviews, and meta-analyses. [3][4][5] this paper reports the outcome from 526 patients who received Mat as part of an international cohort. our aim was to report factors correlated with PROMs (as defined by the Knee injury and Osteoarthritis Outcome Score (KOOS) 6 at two years) and failure rates after Mat.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Patient-reported outcome and survival following meniscal allograft transplantation: an international case series

Barlow

Coco

Shivji

et al. 2022

The Bone & Joint Journal

View full text Add to dashboard Cite

Aims Meniscal allograft transplantation (MAT) for patients with symptomatic meniscal loss has demonstrated good clinical results and survivorship. Factors that affect both functional outcome and survivorship have been reported in the literature. These are typically single-centre case series with relatively small numbers and conflicting results. Our aim was to describe an international, two-centre case series, and identify factors that affect both functional outcome and survival. Methods We report factors that affect outcome on 526 patients undergoing MAT across two sites (one in the UK and one in Italy). Outcomes of interest were the Knee injury and Osteoarthritis Outcome Score four (KOOS4) at two years and failure rates. We performed multiple regression analysis to examine for factors affecting KOOS, and Cox proportional hazards models for survivorship. Results Our results indicate that baseline KOOS4 score affects functional outcome at two years, but no other included factors were significantly related to functional outcome. The only factor that affected failure rate was the presence of cartilage lesions down to bone on both the femur and tibia, decreasing the five-year survivorship from 95% (95% confidence interval (CI) 91 to 99) to 84% (95% CI 74 to 94). Conclusion To our knowledge, this is the largest international cohort reporting on MAT. Our results indicate that factors such as age, BMI, and cartilage lesions down to bone on both the femur and tibia of the affected compartment should not present barriers to offering MAT. Baseline KOOS4 score and the presence of bone-on-bone arthritis can be used to help counsel patients regarding the expected risks and rewards of surgery. Cite this article: Bone Joint J 2022;104-B(6):657–662.

show abstract

Section: Methodsmentioning

confidence: 96%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Patient-reported outcome and survival following meniscal allograft transplantation: an international case series

Barlow

Coco

Shivji

et al. 2022

The Bone & Joint Journal

View full text Add to dashboard Cite

show abstract

“…Due to the length, cost and substantial rehabilitation of meniscal allograft transplantation, it is essential to select appropriate surgical candidates. It has been shown that appropriate candidates are young, healthy and active patients that are symptomatic after a prior meniscectomy and have failed further non-operative management [34]. A systematic review by Fanelli et al found that patients greater than 35 years old had significantly worse patient reported outcomes when compared to their younger counterparts [35].…”

Section: Clinical Evidence Of Needing New Regenerative Strategiesmentioning

confidence: 99%

Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

2021

View full text Add to dashboard Cite

Menisci are crucial structures for knee homeostasis. After a meniscal lesion, the golden rule, now, is to save as much meniscus as possible; only the meniscus tissue that is identified as unrepairable should be excised, and meniscal sutures find more and more indications. Several different methods have been proposed to improve meniscal healing. They include very basic techniques, such as needling, abrasion, trephination and gluing, or more complex methods, such as synovial flaps, meniscal wrapping or the application of fibrin clots. Basic research of meniscal substitutes has also become very active in the last decades. The aim of this literature review is to analyze possible therapeutic and surgical options that go beyond traditional meniscal surgery: from scaffolds, which are made of different kind of polymers, such as natural, synthetic or hydrogel components, to new technologies, such as 3-D printing construct or hybrid biomaterials made of scaffolds and specific cells. These recent advances show that there is great interest in the development of new materials for meniscal reconstruction and that, with the development of new biomaterials, there will be the possibility of better management of meniscal injuries

show abstract

Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints

Kohno

Koga

Ozeki

et al. 2021

Journal Orthopaedic Research

View full text Add to dashboard Cite

The recently developed arthroscopic centralization for lateral meniscal extrusion has obtained satisfactory short‐term clinical and radiological results and improves the meniscus biomechanical properties. However, the effectiveness of treatment for meniscus extrusion after partial meniscectomy still requires elucidation. This study investigated the effect of centralization with modifications from a mechanical viewpoint. Porcine knee joints (N = 6) were set in a universal tester under the following conditions: (1) Intact; (2) Meniscectomy: Inner half of the posterior half meniscus was removed; (3) Extrusion: Posterior meniscus was dislocated laterally by transecting the posterior root and the meniscotibial ligament; (4) Centralization‐1: Centralization procedure using one anchor; (5) Centralization‐2: Centralization procedure using two anchors; and (6) Centralization‐ad: Centralization with capsular advancement using two anchors. Load distributions and contact pressure in the meniscus and tibial cartilage were evaluated with an axial compressive force of 200 N. After meniscectomy, the tibial cartilage load increased and that of the medial margin of the posterior part of the meniscus decreased. When the meniscus was extruded, the load was concentrated only on the tibial cartilage. Centralization‐1 increased the load on the meniscus, while Centralization‐2 further increased the meniscus load but decreased the tibial cartilage load. Centralization‐ad further decreased the load on the tibial plateau. The average contact pressure of the tibial cartilage was significantly higher in the Extrusion group than in the Intact group or the Centralization‐ad group. From a biomechanical viewpoint, centralization with capsular advancement was the most effective of the tested procedures for treatment for an extruded meniscus after partial meniscectomy.

show abstract

Meniscal allograft transplantation: a review of indications, techniques, and outcomes

Cited by 39 publications

References 49 publications

Patient-reported outcome and survival following meniscal allograft transplantation: an international case series

Patient-reported outcome and survival following meniscal allograft transplantation: an international case series

Biomaterials and Meniscal Lesions: Current Concepts and Future Perspective

Biomechanical analysis of a centralization procedure for extruded lateral meniscus after meniscectomy in porcine knee joints

Contact Info

Product

Resources

About