Meningoencephalitis and Brain Abscess Caused by Cladosporium and Fonsecaea

Duque, Oscar

doi:10.1093/ajcp/36.6.505

Cited by 48 publications

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“…Moreover, it conformed to animal models described by others who used C. bantianum as well as W. dermatitidis [1,[4][5][6][7][8].…”

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Experimental infection of mice byFonsecaea pedrosoiandWangiella dermatitidis

Polak¹

1984

Med Mycol

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After i.v. inoculation in cortisone-pretreated mice Fonsecaea pedrosoi produced a chronic infection characterized by black lesions in the skin and subcutis with sclerotic bodies resembling the tissue form of human chromomycosis in addition to lesions in the brain and other organs.Wangiella dermatitidis inoculated into unpretreated mice produced an acute, fatal cerebral infection closely resembling human phaeohyphomycosis. Abundant hyphal growth was observed in the brain tissue.For chemotherapeutical experiments a suitable animal model of human chromomycosis of the skin and of phaeohyphomycosis of other organs including the brain is required. However, in general, the virulence of dematiaceous fungi is extremely low and even cortisone treatment does not enhance the morbidity or the mortality.Of 20 isolates tested in our laboratory one of Fonsecaea pedrosoi and one of Wangiella dermatitidis produced, with the greatest regularity, lesions in mice which resembled chromomycosis and phaeohyphomycosis of the brain respectively with respect to fungal morphology and organ affinity.Fonsecaea pedrosoi CM 27 was grown for one week on Sabouraud dextrose agar (Difco) at 30°C, the surface growth was harvested, ground in a mortar, filtered through a fine cotton mesh to remove debris, and the filtrate was adjusted to an optical density reading of 0-23-0-30 at 600 nm, corresponding to 8× 107 colonyforming units per 0-2 ml.Male Swiss albino mice (bred at the Institute for Biomedical Research, Ffillinsdorf, Switzerland) weighing approximately 20 g were injected with 0-2 ml of this suspension into a lateral tail vein. The mice had to be conditioned by treatment with 2 mg cortisone subcutaneously 90 min before and 24 h after inoculation of the fungus.The infection was evaluated according to the weight, morphological changes of the four legs and the tail of the mice, their general behaviour and survival time. A few days after the injection of this high number of fungus cells, some of the animals died of an acute infection and were excluded from further observation, but most of them survived up to 7th week. During the first 3-4 weeks after inoculation no symptoms of illness were detected. The weight of infected mice was reduced by 17% after 1 week, by 20% after 3 weeks and by 35% after 7 weeks. After 3-4 weeks the legs became 167

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“…Moreover, it conformed to animal models described by others who used C. bantianum as well as W. dermatitidis [1,[4][5][6][7][8].…”

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confidence: 69%

“…This indicates a strong affinity of 14/i. dermatitidis for the nervous system as was described before for Cladosporium bantianum [4].…”

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confidence: 99%

Experimental infection of mice byFonsecaea pedrosoiandWangiella dermatitidis

Polak¹

1984

Med Mycol

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“…There are no reported cases of AIDS-associated pulmonary C. bantiana in the literature. Among the three published confirmed cases of pulmonary C. bantiana, one patient was reported to also have a brain abscess [10][11][12], one was a Thai farmer with non-invasive pulmonary disease (fungus ball [8,13]), and the third was a gardener with Crohn's disease who had taken steroids and had invasive pulmonary disease [4]. Only one had a documented history of immunosuppression, and one had a fungus ball rather than invasive disease.…”

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confidence: 99%

Cladophialophora bantianaisolated from an AIDS patient with pulmonary infiltrates

et al. 1996

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“…Seg6n Lever (21) existen tres formas: la cutinea, que tiene el mayor nfimero de casos publicados y e s , por ende, la mejor estudiada (5,4,15,16); la forma cerebral, caracterizada por la presencia de abscesos, tambi6n muy estudiada (1,28,14,25) e incluso reproducida en forma experimental (12); la tercera forma es la subcut/mea (20,18,17,32,22) que es menos conocida. Seg6n Lever (21) existen tres formas: la cutinea, que tiene el mayor nfimero de casos publicados y e s , por ende, la mejor estudiada (5,4,15,16); la forma cerebral, caracterizada por la presencia de abscesos, tambi6n muy estudiada (1,28,14,25) e incluso reproducida en forma experimental (12); la tercera forma es la subcut/mea (20,18,17,32,22) que es menos conocida.…”

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Abscesos subcutaneos por hongos dematiaceos. presentaci�n de dos casos

1977

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Two cases of subcutaneous abscesses due to dematiaceous fungi are presented. The first, localized in the elbow, exhibited the characteristic microscopic picture of the disorder. The second was localized in the sole, but histologically it showed well-organized mycotic granules much like those reported for eumycetoma. Both patients were asymptomatic and the clinical diagnosis was erroneous. The morphologic, clinical and etiologic aspects are discussed in the text. These cases indicate the need to consider mycotic infections in the differential diagnosis of all lesions which clinically resemble subcutaneous abscesses, so that proper mycological studies can be done and the relationship between the process and the various etiologic agents implicated can be clarified.

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Meningoencephalitis and Brain Abscess Caused by Cladosporium and Fonsecaea

Cited by 48 publications

References 0 publications

Experimental infection of mice byFonsecaea pedrosoiandWangiella dermatitidis

Experimental infection of mice byFonsecaea pedrosoiandWangiella dermatitidis

Cladophialophora bantianaisolated from an AIDS patient with pulmonary infiltrates

Abscesos subcutaneos por hongos dematiaceos. presentaci�n de dos casos

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