Meningoencefalites toxoplásmica e chagásica em pacientes com infecção pelo vírus da imunodeficiência humana: diagnóstico diferencial anatomopatológico e tomográfico

Lazo, Javier; Meneses, Antonio Carlos Oliveira; Rocha, Ademir; Frenkel, J. K.; Marquez, Jaime Olavo; Chapadeiro, E; Lopes, Edison Reis

doi:10.1590/s0037-86821998000200001

Cited by 29 publications

(9 citation statements)

References 14 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Dependendo da causa da admissão, mesmo não sendo a toxoplasmose a responsá-vel, o paciente deve receber o tratamento anti-protozoário profilaticamente ou ser monitorado para posterior tratamento em caso de reagudização da enfermidade por recrudescência dos bradizoítos encistados. Nos pacientes humanos previamente expostos e portadores de cistos teciduais de T. gondii, um grande fator de risco para a manifestação clínica e morte por toxoplasmose é a ocorrência de doença imunossupressora, como por exemplo, a AIDS (Lazo et al 1998, Barsotti & Moraes 2005. Em cães várias condições podem conduzir a imunossupressão como cinomose, leishmaniose, doenças endócrinas, e até mesmo gestação, entre outras.…”

Section: Resultsunclassified

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

et al. 2016

View full text Add to dashboard Cite

RESUMO.-Esse trabalho teve como objetivo estudar a prevalência e respectivos fatores de risco para infecção do Toxoplasma gondii em cães provenientes de uma população We aimed to verify the prevalence and risk factors for Toxoplasma gondii infection in dogs addimitted at the hospital. We also assessed the occurrence rates and the clinical and pathological repercussion of the acute infection by T. gondii in these animals. Antibodies were detected in 7% (26/386) of a population of 386 dogs of both genders and different breeds and ages. Only variables, eating offal, rural origin and contact with cattle have significant values of p<0.05. Dogs from rural areas showed higher risk (OD=7.00) of infection than those of urban origin. In 6.5% (25/386) contact titles were detected (between 16 and 256); these titles do not necessarily mean acute infection, but only prior exposure. The recognition of prior infection by T. gondii is vital in those hospital patients. Depending on the cause of admission, although not being toxoplasmosis the responsible, the patient should receive prophylactic anti-parasite treatment or be monitored for further treatment in case of further acute occurrence of the disease by recrudescence of encysted bradyzoites. Only one dog (3:44%, 1/386) was admitted with high titer, what may be suggestive of acute infection (title of 4096). Although the dog with acute infection has shown neurological signs, caution is required not to extrapolate a false interpretation that toxoplasmosis is the main responsible for neurological signs, since numerous other cases included in this study had neurological signs without title of acute infection, even title of prior contact. Acute toxoplasmosis was not a significant clinic disease in this hospital; however differential diagnosis should be made in ill patients, especially those from rural areas, and definitive diagnosis must be reached for the correct therapeutic approach.

show abstract

Section: Resultsunclassified

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In relation to the clinical focus of each organ affected, this was nonspecific, ranging to the central nervous system from headache, signs of intracranial hypertension, seizures, motor location and coma, generating diagnostic confusion, mainly with toxoplasmosis and tumors of the central nervous system 37,65,66,75,84 . For the heart, it consists of triggering or exacerbating congestive heart failure, arrhythmias, atrioventricular, heart and fascicular blocks 22,27,34,42 .…”

Section: Casesmentioning

confidence: 99%

“…Specifically, the clinical condition refers to the place of the reactivation. Therefore, the neurological condition draws more the attention 25,52,65,66,87 that in most of the times has toxoplasmosis as the main diagnosis in view to the frequency that this condition happens in HIV infected individuals 33,37,68 . In the heart, the symptomatology and the physical aspects overlap those seen on the natural evolution of the chronic chagasic cardiopathy, hindering the diagnosis 22,27,34,42,88 .…”

Section: Casesmentioning

confidence: 99%

“…White matter of the brain hemispheres happened more frequently. Some authors have searched for aspects in the tomographic images and on the MRI of the brain capable of defining the chagasic etiology, as the prevalence of these in the subcortical areas 33,37,68 . The purpose would be to make a differential diagnosis with the toxoplasmosis, whose involvement of the thalamus and the basal ganglia happen more frequently.…”

Section: Casesmentioning

confidence: 99%

See 1 more Smart Citation

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Almeida

Ramos

Correia

et al. 2011

Rev. Soc. Bras. Med. Trop.

114

View full text Add to dashboard Cite

Introduction:The co-infection Trypanosoma cruzi/HIV has been described as a clinical event of great relevance. The objective of this study was to describe clinical and epidemiological aspects published in literature. Methods: It is a systematic review of a descriptive nature from the databases Medline, Lilacs, SciELO, Scopus, from 1980 to 2010. Results: There were 83 articles (2.8 articles/year) with a total of 291 cases. The co-infection was described in 1980 and this situation has become the defining AIDS clinical event in Brazil. This is the country with the highest number of publication (51.8%) followed by Argentina (27.7%). The majority of cases are amongst adult men (65.3%) native or from endemic regions with serological diagnosis in the chronic stage (97.9%) and indeterminate form (50.8%). Both diseases follow the normal course, but in 41% the reactivation of the Chagas disease occurs. The most severe form is the meningoencephalitis, with 100% of mortality without specific and early treatment of the T. cruzi. The medication of choice was the benznidazole on doses and duration normally used for the acute phase. The high parasitemia detected by direct or indirect quantitative methods indicated reactivation and its elevation is the most important predictive factor. The lower survival rate was related to the reactivation of the Chagas disease and the natural complications of both diseases. The role of the antiretroviral treatment on the co-infection cannot yet be defined by the knowledge currently existent. Conclusions: Despite the relevance of this clinical event there are still gaps to be filled.

show abstract

“…A mass effect may be present. [3,10,23,24,28,29]. The imaging may be indistinguishable from that of toxoplasmic encephalitis [8,14,23].…”

Section: Discussionmentioning

confidence: 99%

Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome

Santos¹,

Canela²,

Monção³

et al. 2002

Braz J Infect Dis

View full text Add to dashboard Cite

Reactivation of chronic Chagas' disease is a rare condition and occurs only in immunosuppressed patients. We report a case of a patient with a rapid and fatal reactivation of Chagas' disease, manifested by meningoencephalitis, which lead to a diagnosis of acquired immunodeficiency syndrome (AIDS). We believe there is sufficient evidence to include the reactivation of Chagas' disease among the diagnostic criteria of AIDS in Human Immunodeficiency Virus (HIV) infection.

show abstract

Meningoencefalites toxoplásmica e chagásica em pacientes com infecção pelo vírus da imunodeficiência humana: diagnóstico diferencial anatomopatológico e tomográfico

Cited by 29 publications

References 14 publications

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

Estudo epidemiológico e avaliação de fatores de risco da infecção por Toxoplasma gondii e achados clinico-patológicos da infecção aguda em cães admitidos em um Hospital Escola Veterinário

Co-infection Trypanosoma cruzi/HIV: systematic review (1980 - 2010)

Reactivation of Chagas' disease leading to the diagnosis of acquired immunodeficiency syndrome

Contact Info

Product

Resources

About