Meningococcal Vaccine: Which, When and for Whom?

Gorthi, SP; Nagpal, AK

doi:10.1016/s0377-1237(10)80081-4

Cited by 5 publications

(3 citation statements)

References 4 publications

(3 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Prevention is a potential strategy against IMD, and vaccines could be the best chance of battling this disease as vaccination campaigns have proven effective against IMD outbreaks in the past (Maiden, 2013;Pelton, 2016). Currently, no single vaccine is effective against all serogroups of meningococci, but there are conjugated vaccines against sg-ACWY that protect for approximately 5 years and unconjugated vaccines against sg-B that protect for approximately 3 years (Gorthi and Nagpal, 2010). Worldwide, there are several different vaccination strategies, reflecting a great diversity in which age groups and serogroups are most frequent (Pelton, 2016;Peterson et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study

Hovmand

Lundbo

Kronborg

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

Objectives: Neisseria meningitidis serogroup W incidence has increased. Mortality associated with serogroup W has been higher than for other serogroups. Here we report epidemiological characteristics and risks of poor outcomes associated with invasive meningococcal disease in Denmark since 1980. Methods: All cases of invasive meningococcal disease reported from 1980-2018 were analyzed. Incidence rates by age, sex, manifestation, and serogroup were calculated. Poisson regression was used to analyze the rise in serogroup W, and multivariate logistic analysis was used to analyze risk factors for mortality. Results: A total of 5825 cases were analyzed. Risk of serogroup W infection increased after 2015 compared with all previous periods. Younger (<20 years) and older age (60 years) was associated with an increased risk of serogroup W infection compared with being aged 20-39. Crude case fatality was 12.0%, 11.9%, 9.2%, and 7.9% for serogroups W, Y, C, and B, respectively. After adjustment for age, sex, and manifestation, 30-day mortality was comparable for serogroups. Older age and manifestation with sepsis independently predicted risk of death. Conclusions: Invasive meningococcal disease caused by serogroup W has increased, but serogroup per se was not associated with an increased risk of 30-day mortality.

show abstract

Section: Discussionmentioning

confidence: 99%

Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study

Hovmand

Lundbo

Kronborg

et al. 2021

International Journal of Infectious Diseases

View full text Add to dashboard Cite

show abstract

“…In 2005-2010, the Indian Armed Forces had an average attack rate of 9 or 10 cases of meningococcal disease per year and the N. meningitidis carrier rate among recruits was estimated in the 1990s to be 12%. 60,61 The largest outbreak occurred in 2006, in which 17 cases were reported among a group of soldiers, with disease caused by meningococcal serogroup A. 44 The background incidence of IMD in India has been estimated to be low, with N. meningitidis responsible for 1.9% of the meningitis cases, although this estimation is based on data gathered from 1950 to 2007.…”

Section: Epidemiology Of Meningococcal Disease In Indiamentioning

confidence: 99%

“…In 2005–2010, the Indian Armed Forces had an average attack rate of 9 or 10 cases of meningococcal disease per year and the N. meningitidis carrier rate among recruits was estimated in the 1990s to be 12%. 60 , 61 The largest outbreak occurred in 2006, in which 17 cases were reported among a group of soldiers, with disease caused by meningococcal serogroup A. 44…”

Section: Epidemiology Of Meningococcal Disease In Indiamentioning

confidence: 99%

Mass gatherings: a review of the scope for meningococcal vaccination in the Indian context

Dubey

Hazarika²,

Abitbol³

et al. 2021

Human Vaccines & Immunotherapeutics

View full text Add to dashboard Cite

The risk of meningococcal transmission is increased with crowding and prolonged close proximity between people. There have been numerous invasive meningococcal disease (IMD) outbreaks associated with mass gatherings and other overcrowded situations, including cramped accommodation, such as student and military housing, and refugee camps. In these conditions, IMD outbreaks predominantly affect adolescents and young adults. In this narrative review, we examine the situation in India, where the burden of IMD-related complications is significant but the reported background incidence of IMD is low. However, active surveillance for meningococcal disease is suboptimal and laboratory confirmation of meningococcal strain is near absent, especially in non-outbreak periods. IMD risk factors are prevalent, including frequent mass gatherings and overcrowding combined with a demographically young population. Since overcrowded situations are generally unavoidable, the way forward relies on preventive measures. More widespread meningococcal vaccination and strengthened disease surveillance are likely to be key to this approach.

show abstract

An overview of meningococcal disease in India: Knowledge gaps and potential solutions

John

Gupta

Chitkara

et al. 2013

Vaccine

View full text Add to dashboard Cite

Meningococcal Vaccine: Which, When and for Whom?

Cited by 5 publications

References 4 publications

Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study

Recent increased incidence of invasive serogroup W meningococcal disease: A retrospective observational study

Mass gatherings: a review of the scope for meningococcal vaccination in the Indian context

An overview of meningococcal disease in India: Knowledge gaps and potential solutions

Contact Info

Product

Resources

About