Meningococcal serogroup C serum and salivary antibody responses to meningococcal quadrivalent conjugate vaccine in Saudi Arabian adolescents previously vaccinated with bivalent and quadrivalent meningococcal polysaccharide vaccine

Khalil, Mohamed; Al-Mazrou, Yagob Y.; Findlow, Helen; Chadha, Helen; Castells, Valérie Bosch; Oster, Philipp; Borrow, Raymond

doi:10.1016/j.vaccine.2014.08.026

Cited by 6 publications

(7 citation statements)

References 23 publications

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“…In the case of serogroup C, 90% of the children showed the standard 4-fold increase in antibody concentration at 4-weeks post-vaccination, indicating a typical response (Bertolini et al, 2012; Borrow et al, 2001). Previous studies have consistently demonstrated MCV4 vaccine hyporesponsiveness to serogroup C in subjects previously vaccinated with a meningococcal pure polysaccharide vaccine (MPSV), which was not evident with other serogroups, and suggests that serogroup C may be more sensitive to immune system perturbations (Khalil et al, 2014). Another possibility is that associations were not obtained for other serogroups because a substantial antibody response (for serogroup A) or a more modest response (serogroups Y and W135) to vaccination meant that there was less variation in which to detect a signal associated with parent-child relationship stress.…”

Section: Discussionmentioning

confidence: 99%

Observed parent–child relationship quality predicts antibody response to vaccination in children

O’Connor

Wang

Moynihan

et al. 2015

Brain, Behavior, and Immunity

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Background Quality of the parent-child relationship is a robust predictor of behavioral and emotional health for children and adolescents; the application to physical health is less clear. Methods We investigated the links between observed parent-child relationship quality in an interaction task and antibody response to meningococcal conjugate vaccine in a longitudinal study of 164 ambulatory 10-11 year-old children; additional analyses examine associations with cortisol reactivity, BMI, and somatic illness. Results Observed negative/conflict behavior in the interaction task predicted a less robust antibody response to meningococcal serotype C vaccine in the child over a 6 month-period, after controlling for socio-economic and other covariates. Observer rated interaction conflict also predicted increased cortisol reactivity following the interaction task and higher BMI, but these factors did not account for the link between relationship quality and antibody response. Conclusions The results begin to document the degree to which a major source of child stress exposure, parent-child relationship conflict, is associated with altered immune system development in children, and may constitute an important public health consideration.

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Section: Discussionmentioning

confidence: 99%

Observed parent–child relationship quality predicts antibody response to vaccination in children

O’Connor

Wang

Moynihan

et al. 2015

Brain, Behavior, and Immunity

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“…Only a few studies have looked at the salivary IgA and IgG antibody responses after vaccination with meningococcal conjugate vaccines , and none were performed in a population in sub‐Saharan Africa – the population with highest disease incidence. Salivary IgA antibody responses to MenW and MenY after vaccination have to our knowledge not been studied previously.…”

Section: Introductionmentioning

confidence: 99%

Salivary and Serum Antibody Response Against Neisseria meningitidis After Vaccination With Conjugate Polysaccharide Vaccines in Ethiopian Volunteers

et al. 2016

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Meningococcal conjugate vaccines induce serum antibodies crucial for protection against invasive disease. Salivary antibodies are believed to be important for hindering meningococcal acquisition and/or clearance of established carriage. In this study, we measured salivary IgA and IgG antibodies induced by vaccination with a monovalent serogroup A conjugate vaccine or a tetravalent A, C, W and Y conjugate vaccine, in comparison with antibody levels in serum. Saliva and serum samples from Ethiopian volunteers (1-29 years) collected before and eight times on a weekly basis after receiving the serogroup A conjugate vaccine, the tetravalent serogroup A, C, W and Y conjugate vaccine, or no vaccine (control group), were analysed using a multiplex microsphere immunoassay for antibody detection. Serogroup-specific IgG antibody levels in saliva increased significantly after vaccination with both vaccines. The monovalent serogroup A vaccine also induced an increase in salivary IgA antibodies. A strong correlation between serogroup-specific IgG antibodies in saliva and serum, and a somewhat lower correlation for IgA, was observed for all serogroups. There was also a strong correlation between specific secretory IgA and IgA antibodies in saliva for all serogroups. Meningococcal conjugate vaccines are able to elicit salivary antibodies against serogroup A, C, W and Y correlating with antibody levels in serum. The strong correlation between saliva and serum antibody levels indicates that saliva may be used as a surrogate of systemic antibody responses.

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“…Although secretory IgA elicited by immunization with meningococcal vaccines may have an important role in colonization, such antibodies were not available for our study. Alternatively, we used IgG, which is also present in mucosal secretions of vaccinated individuals ( 21 ). With anti-MenC PS IgG, we used amounts similar to those measured in mucosal secretions ( 21 ).…”

Section: Resultsmentioning

confidence: 99%

“…Alternatively, we used IgG, which is also present in mucosal secretions of vaccinated individuals ( 21 ). With anti-MenC PS IgG, we used amounts similar to those measured in mucosal secretions ( 21 ). The levels of IgG in the mucosa elicited by the protein-based meningococcal vaccines are not known.…”

Section: Resultsmentioning

confidence: 99%

Effect of Vaccine-Elicited Antibodies on Colonization of Neisseria meningitidis Serogroup B and C Strains in a Human Bronchial Epithelial Cell Culture Model

Vianzon

Illek

Moe

2017

Clin Vaccine Immunol

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Capsular polysaccharide-protein conjugate vaccines protect individuals from invasive disease and decrease carriage, which reduces spread of the organism in the population. In contrast, antibodies elicited by plain polysaccharide or protein antigen-based meningococcal (Men) vaccines have little or no effect on decreasing carriage. In this study, we investigated the mechanism by which vaccine-induced human immunoglobulin G (IgG) antibodies affect colonization by meningococcal serogroup B (MenB) or C (MenC) strains using a human bronchial epithelial cell culture model (16HBE14o-). Fluorescence microscopy showed that bacteria colonizing the apical side of 16HBE14o- monolayers had decreased capsular polysaccharide on the bacterial surface that resulted from shedding the capsule and not decreased production of polysaccharide. Capsular polysaccharide shedding depended on the presence of 16HBE14o- cells and bacteria but not direct adherence of the bacteria to the cells. Treatment of bacteria and cells with postimmunization MenC-conjugate IgG or murine anti-MenB polysaccharide monoclonal antibodies (MAbs) inhibited capsule shedding, microcolony dispersal, and invasion of the 16HBE14o- cell monolayer. In contrast, the IgG responses elicited by immunization with MenC polysaccharide (PS), MenB outer membrane vesicle (OMV)-based, or factor H binding protein (FHbp)-based vaccines were not different than preimmune IgG or no-treatment response. The results provide new insights on the mechanism by which high-avidity anticapsular antibodies elicited by polysaccharide-conjugate vaccines affect meningococcal colonization. The data also suggest that any effect on colonization by IgG elicited by OMV- or FHbp-based vaccines may involve a different mechanism.

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Meningococcal serogroup C serum and salivary antibody responses to meningococcal quadrivalent conjugate vaccine in Saudi Arabian adolescents previously vaccinated with bivalent and quadrivalent meningococcal polysaccharide vaccine

Cited by 6 publications

References 23 publications

Observed parent–child relationship quality predicts antibody response to vaccination in children

Observed parent–child relationship quality predicts antibody response to vaccination in children

Salivary and Serum Antibody Response Against Neisseria meningitidis After Vaccination With Conjugate Polysaccharide Vaccines in Ethiopian Volunteers

Effect of Vaccine-Elicited Antibodies on Colonization of Neisseria meningitidis Serogroup B and C Strains in a Human Bronchial Epithelial Cell Culture Model

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