Meningococcal Meningitis: Past and Present Concepts

Bell, William; Silber, David L.

doi:10.1093/milmed/136.7.601

Cited by 10 publications

(8 citation statements)

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“…During World War I, for instance, 2,466 military personnel were admitted with meningococcal meningitis in the United States and 67% survived (Bell & Silber, 1971). During World War I, for instance, 2,466 military personnel were admitted with meningococcal meningitis in the United States and 67% survived (Bell & Silber, 1971).…”

Section: Antimeningococcus Serummentioning

confidence: 99%

“…It was administered by various routes, but sulfadiazine 400 to 600 mg/kg injected intravenously on the first day, followed by a gradual reduction, became the standard regimen (Scheld & Mandell, 1984). In 14,504 military personnel in the United States admitted with meningococcal meningitis during World War II and treated with sulfadiazine, the mortality was only 3.8% (Bell & Silber, 1971). In 14,504 military personnel in the United States admitted with meningococcal meningitis during World War II and treated with sulfadiazine, the mortality was only 3.8% (Bell & Silber, 1971).…”

Section: Sulfonamidesmentioning

confidence: 99%

“…In 1928, Alexander Fleming (1881-1955 discovered penicillin, the first antibiotic that would be commonly used. During World War II, several breakouts of meningococcal meningitis were recorded, especially among military personnel (Bell & Silber, 1971;Tauber & Sande, 1984). During World War II, several breakouts of meningococcal meningitis were recorded, especially among military personnel (Bell & Silber, 1971;Tauber & Sande, 1984).…”

Section: Sulfonamidesmentioning

confidence: 99%

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A History of Acute Bacterial Meningitis

Uiterwijk

Koehler

2012

Journal of the History of the Neurosciences

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Although meningitis was not yet known as such, its symptoms have been conceptualized in different ways and many theories about its causes have been formulated in the course of time. Terms like hydrocephalus and brain fever were used for different clinical manifestations of what today would be recognized as meningitis. Pathological-anatomical findings led to the emergence of the clinical entity from several old concepts of disease. Initially, diagnostic means were limited and therapeutic methods did not differ much from those that had been applied for centuries, even far into the nineteenth century. Discoveries in bacteriology and the introduction of the lumbar puncture provided a new paradigm for knowledge of the pathophysiology and treatment of what then became known with the term meningitis. The development of new therapeutic methods including antiserum, sulfonamides, and penicillin resulted in a decreasing mortality during the past century. Nowadays, with the use of antibiotics, bacterial meningitis can often be cured.

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Section: Antimeningococcus Serummentioning

confidence: 99%

Section: Sulfonamidesmentioning

confidence: 99%

Section: Sulfonamidesmentioning

confidence: 99%

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A History of Acute Bacterial Meningitis

Uiterwijk

Koehler

2012

Journal of the History of the Neurosciences

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“…Although much has been written about this gram-negative pathogen and the variety of clinical manifestations of meningococcal disease, little is known of the direct relationship between the physiology and the biochemistry of the microbe, on the one hand, and the pathogenesis of disease on the other. Previous reviews on the meningococcus and meningococcal disease have dealt primarily with epidemiology (17,22,32,185), pathology (134,142), physiology of the meningococcus (37,222,262), pathogenesis of the disease (19), leukocyte-endotoxin interactions (70), clinical studies (135,195,198), genetics (182), ecology of Neisseria (127), noncapsular surface antigens (97), and meningococcal vaccines (110,180). Although the subject of this review does not make it unique among those which have preceded it, with the information of recent years it is possible to take a fresh look at older ideas and a new look at more current ones.…”

Section: History and Introductionmentioning

confidence: 99%

The meningococcus and mechanisms of pathogenicity.

DeVoe¹

1982

Microbiological Reviews

115

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“…From 1940 to 1945, 14,504 hospital admissions of military personnel were due to this disease. 8 In 1944, Rosenberg and Arling reported their success in treating 65 patients with cerebrospinal fever (in 50 cases meningococci grew in culture, and 15 cases were diagnosed on the basis of clinical presentation). Penicillin was administered intravenously and intrathecally.…”

mentioning

confidence: 99%

Acute Bacterial Meningitis

Roos¹

2000

Semin Neurol

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In the past 10 years the epidemiology of bacterial meningitis has changed, with a decreased incidence of meningitis caused by Haemophilus influenzae and an increasing incidence of meningitis caused by penicillin- and cephalosporin-resistant strains of Streptococcus pneumoniae. Meningococcal meningitis has become an increasing threat to college students. Successful outcome from meningitis requires not only eradication of the bacterial pathogen but also management of the neurological complications of raised intracranial pressure, stroke, and seizure activity. In this article, the pathophysiology, etiology, clinical presentation, differential diagnosis, and management of acute bacterial meningitis are reviewed. The present recommendations for the use of dexamethasone in the treatment of this infection, the use of chemoprophylaxis, and the indications for vaccinations are included.

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Meningococcal Meningitis: Past and Present Concepts

Cited by 10 publications

References 0 publications

A History of Acute Bacterial Meningitis

A History of Acute Bacterial Meningitis

The meningococcus and mechanisms of pathogenicity.

Acute Bacterial Meningitis

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