Meningococcal carriage, meningococcal disease and vaccination

Hassan-King, Musa; Wall, R.A.; Greenwood, Brian

doi:10.1016/s0163-4453(88)96117-8

Cited by 103 publications

(59 citation statements)

References 4 publications

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“…Plain polysaccharide vaccines have little or no impact on carriage, give only short-term immunity, and do not provide herd protection, 32 whereas protein-conjugate polysaccharide vaccines reduce acquisition of nasopharyngeal carriage and transmission, and provide longer lasting immunity and herd protection.…”

Section: Carriage and Herd Protection Nasopharyngeal Carriage Of Neismentioning

confidence: 99%

Meningococcal disease in the Middle East and Africa: Findings and updates from the Global Meningococcal Initiative

Borrow

Caugant

Ceyhan

et al. 2017

Journal of Infection

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Section: Carriage and Herd Protection Nasopharyngeal Carriage Of Neismentioning

confidence: 99%

Meningococcal disease in the Middle East and Africa: Findings and updates from the Global Meningococcal Initiative

Borrow

Caugant

Ceyhan

et al. 2017

Journal of Infection

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“…These studies indirectly suggest a protective role of humoral antibodies in mucosal colonization. In other vaccine trials, however, vaccination with serogroup A capsule did not grant a reduction in carriage rate (2,12). More recently, a significant mucosal immune response has been observed in young adults after immunization with meningococcal AϩC conjugate and polysaccharide vaccines (1).…”

Section: Discussionmentioning

confidence: 99%

Development and Evaluation of an Improved Mouse Model of Meningococcal Colonization

Yi¹,

Stephens

Stojiljković³

2003

Infect Immun

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Studies of meningococcal pathogenesis have been severely restricted due to the absence of an adequate animal model. Given the significance of iron in meningococcal pathogenesis, we developed a model of Neisseria meningitidis colonization in outbred adult mice that included daily administration of iron dextran. While receiving iron, the animals were inoculated intranasally with the initial doses of bacterial suspension. Meningococci were recovered from the animals by nasopharyngeal washes. Approximately half of the animals inoculated with 10 7 CFU remained colonized 13 days after the initial bacterial inoculation. The model was further evaluated with genetically defined isogenic serogroup B mutant strains, and the colonization capabilities of the mutants were compared to that of the wild-type parent. A mutant that produces truncated lipooligosaccharide (KDO 2 -lipid A) and a mutant defective in capsule transport were dramatically impaired in colonization. A mutant defective in pilus transport (pilQ) showed moderately impaired colonization. The immunological aspect of the model was also evaluated by challenging mice after immunization with homologous whole-cell meningococci. The immunized mice were protected from colonization of the homologous strain. In this model, long-term meningococcal colonization was maintained, allowing us to study the effects of specific genetic mutation on colonization. In addition, this model allows investigation of the role of active immune response against meningococci.

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“…[54]). The significant decrease of meningitis incidence in non vaccinated people after a campaign of immunization supports the assumption of effective herd immunity even if the reasons remain largely unexplained [31,[61][62][63][64]. Paradoxically, it has been suggested that increased vaccine coverage may result in an overall decrease in natural immunity at the population level.…”

Section: Immunology and Vaccinesmentioning

confidence: 90%

Control of meningococcal meningitis outbreaks in sub-Saharan Africa

Chippaux

2008

J Infect Dev Ctries

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Outbreaks of Neisseria meningitidis recur frequently in the African Sahel where they are responsible for high mortality and morbidity, especially in children. An effective vaccine has been in existence for more than 30 years, but despite this, the control of epidemics has failed. Moreover, the geographical distribution of N. meningitidis seems to be increasing, perhaps because of climate change but also because of the economic crisis which prevails throughout much of Africa leading to population movements and the breakdown of essential services. Although alarming, the emergence of new serogroups in recent epidemics (such as serogroups X and W135) should not mask the fact that serogroup A remains the most common meningococcal isolate from meningitis cases and is therefore the most significant target for control. The development of a low-cost conjugate meningococcal vaccine should support a strategy of preventive immunization, as this strategy is one that appears most effective to control this plague.

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Meningococcal carriage, meningococcal disease and vaccination

Cited by 103 publications

References 4 publications

Meningococcal disease in the Middle East and Africa: Findings and updates from the Global Meningococcal Initiative

Meningococcal disease in the Middle East and Africa: Findings and updates from the Global Meningococcal Initiative

Development and Evaluation of an Improved Mouse Model of Meningococcal Colonization

Control of meningococcal meningitis outbreaks in sub-Saharan Africa

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