Méningo-encéphalite à tiques chez l’enfant en France : à propos d’un cas

Levy, Michaël; Abi-Wardé, Marie-Thérèse; Rameau, A.C.; Fafi‐Kremer, Samira; Hansmann, Yves; Fischbach, Michel; Higel, Laetitia

doi:10.1016/j.arcped.2016.06.018

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…No TBEV or LIV infected ticks have been detected in our study in France, Denmark, UK, and the Netherlands even if TBE and LIV viruses are known to circulate in those countries (Laursen & Knudsen, 2003, Hansmann et al, 2006, Fomsgaard et al, 2009, Suss, 2011, Gilbert, 2016, Levy et al, 2016, Jahfari et al, 2017. Nevertheless, the prevalence of these viruses in ticks is usually low, and virus detection occurs mainly in local foci where the virus is known to circulate (Perez-Eid et al, 1992, Fomsgaard et al, 2009, Jeffries et al, 2014, Jahfari et al, 2017.…”

Section: Discussioncontrasting

confidence: 53%

Prevalence of tick-borne viruses inIxodes ricinusassessed by high-throughput real-time PCR

Gondard

Michelet

Nisavanh

et al. 2018

Pathogens and Disease

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Ticks are one of the principal arthropod vectors of human and animal infectious diseases. Whereas the prevalence of tick-borne encephalitis virus in ticks in Europe is well studied, there is less information available on the prevalence of the other tick-borne viruses (TBVs) existing worldwide. The aim of this study was to improve the epidemiological survey tools of TBVs by the development of an efficient high-throughput test to screen a wide range of viruses in ticks.In this study, we developed a new high-throughput virus-detection assay based on parallel real-time PCRs on a microfluidic system, and used it to perform a large scale epidemiological survey screening for the presence of 21 TBVs in 18,135 nymphs of I. ricinus collected from five European countries. This extensive investigation has (i) evaluated the prevalence of four viruses present in the collected ticks, (ii) allowed the identification of viruses in regions where they were previously undetected.In conclusion, we have demonstrated the capabilities of this new screening method that allows the detection of numerous TBVs in a large number of ticks. This tool represents a powerful and rapid system for TBVs surveillance in Europe and could be easily customized to assess viral emergence.

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Section: Discussioncontrasting

confidence: 53%

Prevalence of tick-borne viruses inIxodes ricinusassessed by high-throughput real-time PCR

Gondard

Michelet

Nisavanh

et al. 2018

Pathogens and Disease

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“…This region is adjacent to the French region of Alsace. Alsace is the only French region where since 1968 stable endemic TBEV foci have been identified based on autochthonous TBEV infections [ 10 , 11 ]. Overall, about 170 human TBE cases had been reported in France from 1968 until 2016 –almost exclusively from the Alsace department.…”

Section: Introductionmentioning

confidence: 99%

Phylogenetics of tick-borne encephalitis virus in endemic foci in the upper Rhine region in France and Germany

et al. 2018

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ObjectiveTick-borne encephalitis (TBE) caused by the tick-borne encephalitis virus (TBEV) is the most important tick-borne arboviral disease in Europe and Asia. The Upper Rhine Valley is thought to be the very western border of TBEV distribution in Europe. The aim of our study was to identify natural foci and isolate TBEV from ticks, to determine the prevalence of TBEV in local tick populations and to study the phylogenetic relatedness of circulating TBEV strains in this region.Material and methodsTicks were collected between 2016, 2017 and 2018 by flagging. TBEV was isolated from collected ticks and phylogenetic analyses were performed. Minimal infection rates (MIR) of the collected ticks were calculated.ResultsAt 12 sampling sites, a total of 4,064 Ixodes ticks were collected in 2016 and 2017 –(and one single collection 2018). 953 male, 856 female adult ticks and 2,255 nymphs were identified. The MIR rates were 0,17% (1/595) for Schiltach (Germany) and 0,11% (1/944) for Foret de la Robertsau (France), respectively. Overall, the three newly described TBEV strains, isolated in the years 2016 and 2017 from the Upper Rhine Valley have no close phylogenetic relation and show a genetic relationship with strains from eastern Europe. The 2018 TBEV strain from Aubachstrasse (Germany), however, is closely related to the TBEV found in Schiltach (Germany).ConclusionIn conclusion, we demonstrate, to our knowledge for the first time, the phylogenetic relations of the newly isolated TBEV strains on both sides of the upper Rhine river.

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