Meningitis por Kingella kingae

Extremera, Verónica Cantarín; González, J. Álvarez-Coca; Pérez, J. Martínez; Nieto, Juan Antonio; Villanueva, J.L. Rubio

doi:10.1157/13107403

Cited by 5 publications

(7 citation statements)

References 10 publications

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“…Kingella kingae meningitis may result from the hematogenous seeding of the organism in the central nervous system during a bacteremic episode (276)(277)(278)(279)(280) or by migration of septic emboli or rupture of a mycotic aneurism in patients with endocarditis (113,132,138,242,245,272). The disease has been diagnosed in children (113,138,245,(277)(278)(279)(280), adolescents (139), and adults (132,242,272,276).…”

Section: Meningitismentioning

confidence: 99%

“…The disease has been diagnosed in children (113,138,245,(277)(278)(279)(280), adolescents (139), and adults (132,242,272,276). The clinical course of K. kingae meningitis secondary to endocardial infection is severe and may leave permanent neurological sequelae such as hemiplegia (280) or hemiparesis (272), aphasia (272), and ophthalmoplegia (139) among survivors.…”

Section: Meningitismentioning

confidence: 99%

“…Patients with K. kingae endocarditis are administered a high dose of intravenous ␤-lactam antibiotic as monotherapy or combined with an aminoglycoside drug for 4 to 7 weeks (18). In the past, patients with central nervous system infections caused by K. kingae were treated with a penicillin drug alone (139) or in combination with chloramphenicol (278,280), but currently, a third-generation cephalosporin (cefotaxime or ceftriaxone) as monotherapy or in combination with an aminoglycoside for 10 days to 4 weeks is preferred (276,277,279).…”

Section: Treatmentmentioning

confidence: 99%

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Kingella kingae: Carriage, Transmission, and Disease

2015

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SUMMARY Kingella kingae is a common etiology of pediatric bacteremia and the leading agent of osteomyelitis and septic arthritis in children aged 6 to 36 months. This Gram-negative bacterium is carried asymptomatically in the oropharynx and disseminates by close interpersonal contact. The colonized epithelium is the source of bloodstream invasion and dissemination to distant sites, and certain clones show significant association with bacteremia, osteoarthritis, or endocarditis. Kingella kingae produces an RTX (repeat-in-toxin) toxin with broad-spectrum cytotoxicity that probably facilitates mucosal colonization and persistence of the organism in the bloodstream and deep body tissues. With the exception of patients with endocardial involvement, children with K. kingae diseases often show only mild symptoms and signs, necessitating clinical acumen. The isolation of K. kingae on routine solid media is suboptimal, and detection of the bacterium is significantly improved by inoculating exudates into blood culture bottles and the use of PCR-based assays. The organism is generally susceptible to antibiotics that are administered to young patients with joint and bone infections. β-Lactamase production is clonal, and the local prevalence of β-lactamase-producing strains is variable. If adequately and promptly treated, invasive K. kingae infections with no endocardial involvement usually run a benign clinical course.

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Section: Meningitismentioning

confidence: 99%

Section: Meningitismentioning

confidence: 99%

Section: Treatmentmentioning

confidence: 99%

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Kingella kingae: Carriage, Transmission, and Disease

2015

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“…The current report describes a rare case of a 10-year-old previously healthy child with K. kingae meningitis. Since 1983, only 8 pediatric cases of meningitis caused by K. kingae have been published (Table 1, Supplemental Digital Content 1, http://links.lww.com/INF/E341), 3–10 7 of which occurred in children under the age of 5, 3 had endocarditis and only 1 case of isolated meningitis occurred in a previously healthy teenager (17 years old). Patients were treated with beta-lactam antibiotics (isolated or combined with chloramphenicol) or the third generation cephalosporins combined with glycopeptide or aminoglycosides.…”

Section: Discussionmentioning

confidence: 99%

“…2 It has very seldomly been reported as a cause of bacterial meningitis, and there are only 8 cases previously reported. 3–10…”

mentioning

confidence: 99%