Meningitis in late onset sepsis

Arora, Vivek; Sharma, Lalit Mohan; Jangid, Dinesh Kumar; Choudhary, Vijay; Bairwa, Ram Prakash; Singla, Sanjay

doi:10.18203/2349-3291.ijcp20171727

Cited by 4 publications

(4 citation statements)

References 2 publications

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“…The prevalence of neonatal meningitis in clinical sepsis at the Neonatal Intensive Care Unit, Sanglah General Hospital Denpasar was 68.8% [7]. A study by Arora et al also reported 55 cases of meningitis (61.11%) in 90 patients with suspected late-onset neonatal sepsis [8].…”

Section: Introductionmentioning

confidence: 97%

“…It can cause a delay in diagnosis and in turn, affect the prognosis and survival of patients [10]. The mortality rate in neonates with meningitis in suspected late-onset sepsis was 45.5% [8]. Based on this background, we need to identify the risk factors of bacterial meningitis in late-onset neonatal sepsis at Sanglah General Hospital, Denpasar.…”

Section: Introductionmentioning

confidence: 99%

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The Risk Factors of Bacterial Meningitis in Late-Onset Neonatal Sepsis

Noviyani

Kardana

Mahalini

et al. 2021

Open Access Maced J Med Sci

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BACKGROUND: Neonatal bacterial meningitis has a significant contribution on neonatal morbidity and mortality. It is the most common complication of late-onset neonatal sepsis. An understanding of the risk factors for bacterial meningitis in late-onset neonatal sepsis is required to provide comprehensive management. AIM: To identify the risk factors of bacterial meningitis in late-onset neonatal sepsis. METHODS: This is an analytical study with a case–control design, conducted in May 2019-February 2021, involving neonates aged 4–28 days who suffered from late-onset neonatal sepsis in Level II and III Neonatal Care Unit, Sanglah General Hospital Denpasar. Statistical analysis was performed using Chi-square and logistic regression. RESULTS: A total of 54 patients were analyzed in this study. The mean age of subjects with neonatal bacterial meningitis was 13 days and the majority of them were male (51.9%). The risk factor of bacterial meningitis in late-onset neonatal sepsis was gestational age <37 weeks with odds ratio 4.22 (95% confidence interval 1.28–13.86, p = 0.01). There was no significant association of birth weight <2500 g, neonatal asphyxia, and invasive procedure on neonatal bacterial meningitis. CONCLUSION: Gestational age <37 weeks is a risk factor for bacterial meningitis in late-onset neonatal sepsis.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

The Risk Factors of Bacterial Meningitis in Late-Onset Neonatal Sepsis

Noviyani

Kardana

Mahalini

et al. 2021

Open Access Maced J Med Sci

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“…Sepsis is the most common cause of newborn mortality, accounting for 30 to 50 percent of all neonatal fatalities each year [1]. Early onset sepsis (EOS) and late onset sepsis (LOS) are two types of neonatal sepsis [4]. In the first month, it is characterized by signs and symptoms of infection, with or without bacteremia in the first month of life.…”

Section: Introductionmentioning

confidence: 99%

Frequency of Meningitis in Patients Presenting with Neonatal Sepsis at a Tertiary Care Hospital: A Cross-Sectional Study

Kumar¹,

Yahya²,

Raza

et al. 2022

JPRI

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Aim: To investigate the prevalence of meningitis in neonatal sepsis patients at a tertiary care hospital. Study Design: A cross-sectional study. Place and Duration: Department of pediatrics, Civil Hospital Karachi from 11 – 2019 to 04 – 2020. Methodology: A total of 120 Neonates within first 28 days of life with positive blood culture were included in this study. Patient’s data was collected on a predesigned proforma including demographics. Diagnosis of meningitis was done by performing lumber puncture. CSF analysis, blood, and CSF cultures were all tested in the lab. Results: The average age of the patients was 10.75±7.24 days. There were 66(55%) males and 54(45%) females. Meningitis was found in 23.33% of patients with neonatal sepsis (28/120). Rate of meningitis was significantly high in late onset of sepsis as compared to early onset of sepsis (32.8% vs. 11.3%; p=0.006). Conclusion: In this study the frequency of meningitis with neonatal sepsis was high. Meningitis has a strong link to neonatal sepsis, and it must be ruled out in those babies to avoid neurological problems.

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“…8 In another study, meningitis in LOS was 61.1%. 9 Researches done to look for frequency of meningitis in LOS have been found to have variability while very limited work is seen at local level in this regard. The findings of this study were thought to help us in better understanding the burden of meningitis among LOS in our https://doi.org/10.29309/TPMJ/2020.27.11.4600 population while it will also open doors for newer research protocols looking at priorities for the management of affected patients.…”

Section: Introductionmentioning

confidence: 99%

Meningitis in neonates having late onset sepsis.

Ahmad¹,

Hussain

Rafique³

et al. 2020

TPMJ

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Objectives: Majority of the researchers reporting incidence and etiology surrounding neonatal sepsis along with meningitis are from developed countries while limited work is noticed from developing countries where overall burden of these disease are immense. The current study was aimed to determine the frequency of meningitis in children having late-onset sepsis (LOS). Study Design: Descriptive Case Series study. Setting: Department of Pediatrics Medicine, Nishter Medical University Multan and DHQ Teaching Hospital, Dera Ghazi Khan. Period: From July to December 2019. Material & Methods: A total of 206 neonates of both gender, older than 72 hours, admitted and diagnosed with sepsis were enrolled. Meningitis was labeled in a neonate if his/her cerebrospinal fluid (CSF) contains > 30 leukocytes/mm3, and any one of these two: protein >200mg/dl or sugar <40mg/dl. Results: Out of a total of 206 neonates having LOS, majority, 111 (53.9%) were male and 73 (35.4%) were aged 3 to 7 days. Overall, mean weight was found to be 2.68+0.51 kg. A total of 84 (40.8%) neonates were preterm. Frequency of meningitis was found in 44 (21.4%) neonates. Neonates having low body weight and being preterm were noted to have significant associations (p value < 0.05) with meningitis. Conclusion: Frequency of meningitis in neonates with LOS was high. Low body weight and preterm neonates having LOS were found to have significant association with the presence of meningitis.

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Meningitis in late onset sepsis

Cited by 4 publications

References 2 publications

The Risk Factors of Bacterial Meningitis in Late-Onset Neonatal Sepsis

The Risk Factors of Bacterial Meningitis in Late-Onset Neonatal Sepsis

Frequency of Meningitis in Patients Presenting with Neonatal Sepsis at a Tertiary Care Hospital: A Cross-Sectional Study

Meningitis in neonates having late onset sepsis.

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