Meningitis Carcinomatosa: A Report on Two Cases

Dixon, Gordon; Kerr, Alan Sutcliffe; Sharp, Mary

doi:10.1093/brain/69.3.223

Cited by 11 publications

(3 citation statements)

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“…Among GI primary tumors, NM secondary to gastric carcinoma is reported most commonly 5–22. We were able to identify 60 reports of NM due to gastric carcinoma dating from 1912 through 2004.…”

Section: Discussionmentioning

confidence: 99%

Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract

Giglio

Weinberg

Forman

et al. 2005

Cancer

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BACKGROUND Neoplastic meningitis (NM) occurs in 5–10% of patients with malignant disease. Little is known about the outcomes of patients with gastrointestinal (GI) malignancies who develop NM. For this report, the authors characterized the clinical course and attempted to identify prognostic factors in patients with NM due to primary malignancies of the GI tract. METHODS In this retrospective study, 21 patients with GI primary tumors and NM were identified: Their medical records and imaging studies were reviewed. RESULTS The patient population was composed of patients with gastric adenocarcinoma (n = 8 patients), esophageal adenocarcinoma (n = 7 patients), colon and/or rectal adenocarcinoma (n = 5 patients), and pancreatic adenocarcinoma (n = 1 patient). The median overall survival after the initial diagnosis of adenocarcinoma was 55 weeks (range, 8–884 wks), and the median survival after the diagnosis of NM was 7 weeks (range, 0–64 wks). Four patients died during palliative radiotherapy. No factors identified had an impact on outcome, including symptoms, physical findings at diagnosis, imaging characteristics, or cerebrospinal fluid findings. Univariate analysis showed a trend toward better outcomes for patients who received any kind of treatment directed toward the NM. CONCLUSIONS Patients with NM from GI tract adenocarcinomas universally had poor outcomes. Until NM can be diagnosed earlier and/or until more effective therapies are identified, comfort care alone may be a reasonable alternative for some of these unfortunate patients. Cancer 2005. © 2005 American Cancer Society.

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Section: Discussionmentioning

confidence: 99%

Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract

Giglio

Weinberg

Forman

et al. 2005

Cancer

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“…Visual failure as an important component of the syndrome generally received insufficient emphasis in the ophthalmological and neurological literature (Dixon, Kerr, and Sharp, 1946;Grain andKarr, 1955) until 1955, when Fischer-Williams et al pointed out that partial or complete blindness occurs in one-third of such patients. In 1961, Katz, Valsamis, and Jampel in a review of the neuro-ophthalmological findings in meningeal carcinomatosis described decreased vision in 4400 of cases.…”

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confidence: 99%

Meningeal carcinomatosis and blindness

Altrocchi

Eckman

1973

Journal of Neurology, Neurosurgery & Psychiatry

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SUMMARY The clinical syndrome of meningeal carcinomatosis includes headache, dementia, radiculopathy, and cranial nerve palsies. Blindness may be the first, or most prominent, symptom. When blindness occurs in adult life, meningeal carcinomatosis should be included in the differential diagnosis, even in the absence of other symptoms and in the absence of known malignancy. Although all pathophysiological mechanisms of the blindness in meningeal carcinomatosis have not yet been elucidated, optic nerve involvement by meningeal tumour-cuffing, by chronic papilloedema, and by direct tumour infiltration represent the likeliest causes. In the neuropathological analysis of such cases, the importance of analysing the intra-orbital portion of the optic nerves, in addition to the portions of the optic nerve and chiasm usually examined at routine necropsy, is emphasized. A case is described to illustrate this point, with the only pathological abnormality in the optic nerves being found within 6 mm of the retina.

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“…καί Resnick, J.S. ), Vital, Cl., Bruno -Martin, Fr., Henry, P., Bergouignon, Μ. καί Leger, H. (1970 καί Sharp, M.E. (1946), Kmerim, G. (1908), Berg, L. (1953).…”

Section: ονοματολογια -ορισμοςmentioning

confidence: 99%

Συμβολη Εις Την Μελετην Της Λεπτομηνιγγικης Καρκινωματωσεως. (Κλινικο- Παθολογοανατομικη Μελετη)

Κοκκορησ¹

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Meningitis Carcinomatosa: A Report on Two Cases

Cited by 11 publications

References 0 publications

Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract

Neoplastic meningitis in patients with adenocarcinoma of the gastrointestinal tract

Meningeal carcinomatosis and blindness

Συμβολη Εις Την Μελετην Της Λεπτομηνιγγικης Καρκινωματωσεως. (Κλινικο- Παθολογοανατομικη Μελετη)

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