Meningite por Haemophilus influenzae tipo f

Cardoso, Marta Pessoa; Pasternak, Jacyr; Giglio, Alfredo Elias; Troster, Eduardo Juan

doi:10.1590/s1679-45082013000400020

Cited by 10 publications

(5 citation statements)

References 8 publications

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“…Transfection of p100 or p52 coupled with RANKL stimulation abolished this impairment. Overexpression of RelB also abolished these changes in another aly/aly model (40). The RANKL-controlled osteoprotegerin (OPG) system has been shown to be dysregulated in UC and CD patients, and is correlated with increased bone loss in patient sub-groups (41).…”

Section: Starting the Engine: Non-canonical Nf-κb Stimulatory Ligandsmentioning

confidence: 89%

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

McDaniel

Eden

Ringel

et al. 2016

Inflammatory Bowel Diseases

121

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Crohn’s disease and ulcerative colitis are common and debilitating manifestations of inflammatory bowel disease (IBD). IBD is characterized by a radical imbalance in the activation of pro-inflammatory and anti-inflammatory signaling pathways in the gut. These pathways are controlled by NF-κB, which is a master regulator of gene transcription. In IBD patients, NF-κB signaling is often dysregulated resulting in overzealous inflammation. NF-κB activation occurs through two distinct pathways, defined as either canonical or non-canonical. Canonical NF-κB pathway activation is well studied in IBD and is associated with the rapid, acute production of diverse pro-inflammatory mediators, such as COX-2, IL-1β, and IL-6. In contrast to the canonical pathway, the non-canonical or “alternative” NF-κB signaling cascade is tightly regulated and is responsible for the production of highly specific chemokines that tend to be associated with less acute, chronic inflammation. There is a relative paucity of literature regarding all aspects of non-canonical NF-κB signaling. However, it is clear that this alternative signaling pathway plays a considerable role in maintaining immune system homeostasis and likely contributes significantly to the chronic inflammation underlying IBD. Non-canonical NF-κB signaling may represent a promising new direction in the search for therapeutic targets and biomarkers associated with IBD. However, significant mechanistic insight is still required to translate the current basic science findings into effective therapeutic strategies.

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Section: Starting the Engine: Non-canonical Nf-κb Stimulatory Ligandsmentioning

confidence: 89%

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

McDaniel

Eden

Ringel

et al. 2016

Inflammatory Bowel Diseases

121

View full text Add to dashboard Cite

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“…We report a case of a 12-month-old, immunocompetent female that presented with Haemophilus influenza type f meningitis and a clinical course complicated by bilateral subdural empyemas, central venous thrombosis, and bilateral sensorineural hearing loss. Her initial presentation was significant for viral infection positive for adenovirus and recent history of bilateral acute otitis media which may have predisposed her to colonization and infection [6, 7]. Apart from sensorineural hearing loss, these complications have not been reported in the literature for Haemophilus influenzae type f [8, 9] and should be considered in the care of these patients despite clinical appearance given the severity of complications and potential for acute decompensation.…”

Section: Discussionmentioning

confidence: 99%

Haemophilus influenzae Type f Meningitis Complicated by Bilateral Subdural Empyema, Central Venous Thrombosis, and Bilateral Sensorineural Hearing Loss in an Immunocompetent 12-month-old

Panning

Mehta

2019

Cureus

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Haemophilus influenzae is a gram-negative coccobacillus that colonizes the nasopharyngeal surface and upper respiratory tract of healthy individuals and includes six encapsulated serotypes as well as non-encapsulated, non-typeable strains. Since the widespread use of the Haemophilus influenzae type b (Hib) conjugate vaccine implemented in 1990, the majority of invasive illness now seen in the United States is secondary to capsular serotypes other than type b and non-typeable strains with the largest burden of disease affecting the extremes of age-infants and the elderly. We report a case of acute Haemophilus influenzae type f meningitis in a 12-month-old female who was previously healthy and had been fully immunized. She demonstrated clinical improvement on ceftriaxone, but persistent fever and ear-tugging resulted in obtaining an MRI that displayed bilateral subdural empyemas requiring burr-hole craniotomy, central venous thrombosis requiring anticoagulation, and bilateral sensorineural hearing loss requiring cochlear implants. Immunological studies confirmed immunocompetency and appropriate response to her previous Hib vaccination, suggesting a significant impact of bacterial virulence. These complications, with the exception of sensorineural hearing loss, have not been reported in the literature for Haemophilus influenzae type f and should be considered in the care of these patients despite clinical appearance given the severity of complications and potential for acute decompensation. Despite the success of vaccination in reducing invasive disease, cases of H. influenzae meningitis continue to occur via less common encapsulated serotypes with unknown complications, making the management and treatment of these infections more difficult for practitioners.

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“…Therefore, in the face of the gradual increase of Hif infections, further continuous monitoring of invasive Hi diseases is certainly required. 1 , 2 , 4 …”

Section: Discussionmentioning

confidence: 99%

“…At the same time, invasive infections caused by NTHi, H. influenzae serotype f (Hif) and other serotypes have been reported more frequently. 1 , 2 Mostly they have occurred among toddlers, older people and patients with coexisting comorbidities, fatal outcomes have been relatively rare. 1 , 3 , 4 , 5 …”

Section: Introductionmentioning

confidence: 99%

Invasive Haemophilus influenzae Serotype f Case Reports in Mazovia Province, Poland

et al. 2016

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After successful introduction of anti-Haemophilus influenzae (Hi) serotype b vaccination program in Poland, invasive non-b or nontypeable H. influenzae infections have been reported more frequently alike in other countries all over the world. In this paper, we report 2 cases of H. influenzae serotype f (Hif) meningitis with severe clinical presentations which are rarely seen in previously healthy children.The first case is a 6-year-old girl who was admitted to pediatric ward with signs of meningitis. Laboratory tests confirmed bacteremic meningitis caused by Hif. The girl responded very well to administered treatment and recovered without any further complications. No underlying comorbidities were found. The second patient was a 4-year-old boy who, in course of Hif bacteremic meningitis, developed rapid septicemia and, despite aggressive treatment, died within a few hours of hospitalization. The child's past history was unremarkable.By presenting these cases, we would like to remind clinicians that invasive non-b Hi infections can become fatal not only in the group of the youngest children or children with coexisting comorbidities, as most commonly reported in the worldwide literature. At the same time, we want to emphasize the legitimacy of constant monitoring Hi epidemiology in order to take accurate actions if necessary.

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Meningite por Haemophilus influenzae tipo f

Cited by 10 publications

References 8 publications

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

Emerging Roles for Noncanonical NF-κB Signaling in the Modulation of Inflammatory Bowel Disease Pathobiology

Haemophilus influenzae Type f Meningitis Complicated by Bilateral Subdural Empyema, Central Venous Thrombosis, and Bilateral Sensorineural Hearing Loss in an Immunocompetent 12-month-old

Invasive Haemophilus influenzae Serotype f Case Reports in Mazovia Province, Poland

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