Meningiomas Related to the Chernobyl Irradiation Disaster in North-Eastern Romania Between 1990 and 2015

Abstract

Even if meningiomas are the most common radio-induced tumors that occur in the adult population, the epidemiology of these types of tumors after Chernobyl nuclear accident, is still unclear. This paper aims to determine the tumoral behavior of intracranial meningiomas in North-Eastern Romania, affected by the radioactive cloud from Chernobyl nuclear accident , over a period of 25 years, namely between 1990 and 2015. Our research consists of an analytical, observational, cohort-based and retrospective study, conducted in Prof. Dr. N. Oblu Clinical Emergency Hospital of Iasi, Romania, on a group of 1287 patients diagnosed with intracranial meningiomas and operated between 1990 and 2015. In these period there was an increased number of intracranial meningiomas, with first peak between 1993-1996 and the second peak between 2007-2015, corresponding to 7-10 years and 21-30 years, after the Chernobyl accident. Regarding the annual frequency of histopathologic grading, for grade I meningiomas there were no trend or cyclicity of the cases diagnosed each year, but for grade II and III meningiomas there were an ascending trend in the period 1996-2000, that corresponds to the 10-14 years from the Chernobyl accident.

Anatomical localization of intracranial grade II meningiomas in North-Eastern Romania

“…Meningiomas makes up about one third of all primary central nervous system tumours, being the most common brain tumour in adults over the age of 35 (1), with an incidence that has increased in recent years (2,3). As far as Romania is concerned, an increase in the number of intracranial meningiomas was noted in its North-Eastern region (where this research was conducted) over the 1990-2015 period (4). Although meningiomas are usually benign slow-growing tumours, their histological aggressiveness may classify them in grade II or III tumours, according to the WHO classification (5,6).…”

Tumor recurrence in parasagittal and falcine atypical meningiomas invading the superior sagittal sinus

“…Meningiomas account for approximately one third of all intracranial tumors, being the most common primary intracranial neoplasm [ 1 ] and some of our previous studies have shown an increasing incidence and that these tumors are relative common in the north-eastern region of Romania [ 2 , 3 , 4 , 5 ].…”

The tumour volume influence on tumour recurrence and progression-free survival in the case of atypical meningiomas

“…Meningiomas are the most common primary intracranial tumors in adults and represent about one third of them (26). Out of the histopathological grades of meningiomas, AMs (WHO grade II meningiomas) represent approximately 20-30% of them (27,28,33), and their incidence has increased in the last years (10,33).…”