Meningiomas of the basal posterior fossa. Surgical experience in 80 cases

Lobato, R.D.; González, P.; Alday, Rafael Escudero; Ramos, Ana; Lagares, Alfonso; Alén, J.F.; Palomino, J.C.; Miranda, Pablo; Pérez-Núñez, Ángel; Arrese, Ignacio

doi:10.1016/s1130-1473(04)70439-x

Cited by 34 publications

(23 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…At the present moment the majority of authors recommend subtotal resection for old patients or when there are factors defying complete removal7,12,17). The critical factors influencing the possibility of radical and safe resection of meningiomas are tumor-vascular relationships and the integrity of the arachnoid plane between the tumor and the brainstem19). In our series, non-skull base location was a significant factor for complete resection.…”

Section: Discussionmentioning

confidence: 57%

“…And, surgical results with infratentorial meningiomas have much improved during the last two decades, but radical removal continues producing a high morbidity rate and still occasional mortality19).…”

Section: Discussionmentioning

confidence: 99%

“…The recurrence rate of infratentorial meningiomas is particularly difficult to estimate because of differences in the reported series regarding the rates of radical excision, the methods of assessment of complete removal, the follow-up periods, the average age of the patients and the percentage of patients receiving postoperative radiotherapy19). Some studies have shown that meningiomas may recur after an apparently radical excision, but it is clear that completeness of resection is the main factor preventing regrowth in all locations1,4,17).…”

Section: Discussionmentioning

confidence: 99%

“…But the attempt for aggressive surgical resection continues producing a high morbidity rate and still occasional mortality19). The perioperative mortality rate in the surgical management of infratentorial meningiomas has varied from 0-15.7%25).…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Surgical Experience of Infratentorial Meningiomas : Clinical Series at a Single Institution during the 20-Year Period

Jung

Moon

Lee

et al. 2014

J Korean Neurosurg Soc

View full text Add to dashboard Cite

ObjectiveBased on surgical outcomes of patients with infratentorial meningiomas surgically treated at our institution, we analyzed the predictors for surgical resection, recurrence, complication, and survival.MethodsOf surgically treated 782 patients with intracranial meningioma, 158 (20.2%) consecutive cases of infratentorial location operated on between April 1993 and May 2013 at out institute were reviewed retrospectively. The patients had a median age of 57.1 years (range, 16--77 years), a female predominance of 79.7%, and a mean follow-up duration of 48.4 months (range, 0.8--242.2 months).ResultsGross total resection (Simpson's grade I & II) was achieved in 81.6% (129/158) of patients. Non-skull base location was an independent factor for complete resection. The recurrence rate was 13.3% (21/158) and the 5-, 10-, and 15-year recurrence rates were 8.2%, 12.0%, and 13.3%, respectively. Benign pathology, postoperative KPS over than 90, low peritumoral edema, and complete resection were significantly associated with longer recurrence-free survival rate. The 5-, 10-, and 15-year survival rates were 96.2%, 94.9%, and 94.9%, respectively. Benign pathology, postoperative KPS over than 90 and complete resection were significantly associated with a longer survival rate. The permanent complication rate was 13% (21/158). Skull base location and postoperative KPS less than 90 were independent factors for the occurrence of permanent complication.ConclusionOur experience shows that infratentorial meningiomas represent a continuing challenge for contemporary neurosurgeons. Various factors are related with resection degree, complications, recurrence and survival.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical Experience of Infratentorial Meningiomas : Clinical Series at a Single Institution during the 20-Year Period

Jung

Moon

Lee

et al. 2014

J Korean Neurosurg Soc

View full text Add to dashboard Cite

show abstract

“…[14][15][16][17][18][19][20][21][22][23][24][25][26] Indeed, middle and posterior fossa tumors can cause facial pain with symptoms similar to trigeminal neuralgia, whereas peripheral tumors cause facial pain with associated sensory loss. 14 In a study of 161 patients with posterior fossa meningiomas, 50% presented with headaches, 16% with facial pain, 1% with facial spasm, and 15.5% with swallowing symptoms, whereas the trigeminal nerve was affected in 38% of the cases.…”

Section: Commentary and Analysismentioning

confidence: 99%

Dental X-Rays and Risk of Meningioma; the Jury is Still Out

Tetradis

White

2012

Journal of Evidence Based Dental Practice

View full text Add to dashboard Cite

Increased expression of avian erythroblastosis virus E26 oncogene homolog 1 in World Health Organization grade 1 meningiomas is associated with an elevated risk of recurrence and is correlated with the expression of its target genes matrix metalloproteinase‐2 and MMP‐9

Okuducu

Zils

Michaelis

et al. 2006

Cancer

View full text Add to dashboard Cite

BACKGROUND The transcription factor avian erythroblastosis virus E26 (V‐Ets) oncogene homolog 1 (Ets‐1) is involved in tumor development and progression through the transcriptional regulation of several matrix‐degrading enzyme systems, including matrix metalloproteinases (MMPs). It has been demonstrated that the MMPs are expressed strongly in high‐grade meningiomas. To determine the biologic significance of Ets‐1 in the progression of benign meningiomas, the authors investigated the expressions of Ets‐1 and its target genes MMP‐2 and MMP‐9 in primary and recurrent, Grade 1 meningiomas. METHODS The expression levels of Ets‐1, MMP‐2, and MMP‐9 were examined by immunohistochemistry in 70 Grade 1 meningiomas, including 36 primary tumors without recurrence after 5 years of follow‐up and 17 pairs of primary tumors and subsequent recurrences. RESULTS The results demonstrated higher expression of Ets‐1, MMP‐2, and MMP‐9 proteins in meningiomas with subsequent recurrences compared with meningiomas from patients who had no recurrences (P < .001). In addition, Ets‐1 expression was correlated with the expression of both MMP‐2 and MMP‐9. CONCLUSIONS Ets‐1 may be involved in meningioma recurrence by up‐regulating MMP‐2 and MMP‐9. Increased expression of these genes in World Health Organization grade 1 meningiomas may serve as an indicator for a high risk of recurrence. Cancer 2006. © 2006 American Cancer Society.

show abstract

Meningiomas of the basal posterior fossa. Surgical experience in 80 cases

Cited by 34 publications

References 67 publications

Surgical Experience of Infratentorial Meningiomas : Clinical Series at a Single Institution during the 20-Year Period

Surgical Experience of Infratentorial Meningiomas : Clinical Series at a Single Institution during the 20-Year Period

Dental X-Rays and Risk of Meningioma; the Jury is Still Out

Increased expression of avian erythroblastosis virus E26 oncogene homolog 1 in World Health Organization grade 1 meningiomas is associated with an elevated risk of recurrence and is correlated with the expression of its target genes matrix metalloproteinase‐2 and MMP‐9

Contact Info

Product

Resources

About