Meningiomas in children and adolescents: a meta-analysis of individual patient data

Kotecha, Rishi S.; Pascoe, Elaine M.; Rushing, Elisabeth J.; Rorke-Adams, Lucy B.; Zwerdling, Theodore; Gao, Xing; Li, Xin; Greene, Stephanie; Amirjamshidi, Abbas; Kim, Seung Ki; Lima, Marco Antônio; Hung, Po Cheng; Lakhdar, F.; Mehta, Nirav; Liu, Yuguang; Devi, Bhagavatula Indira; Sudhir, Bhanu Jayanand; Lund‐Johansen, Morten; Gjerris, F.; Cole, Catherine; Gottardo, Nicholas G.

doi:10.1016/s1470-2045(11)70275-3

Cited by 146 publications

(211 citation statements)

References 48 publications

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“…A possible explanation may be the influence of puberty on meningioma type. [5,6] Postpubertal meningiomas are thought to be similar to the adult form and a higher proportion occur in female patients. [6] Meningiomas in patients under the age of 12 tend to occur more commonly in males, which was confirmed in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Meningiomas in this age group usually have a worse prognosis when compared to older children due to higher operative mortality and morbidity. [6] The majority of patients showed signs of increased intracranial pressure at the time of initial presentation, and presented with additional clinical symptoms based on the location of their mengionomas ( Table 1). …”

Section: Discussionmentioning

confidence: 99%

“…[6] Similar to the adult population, most meningiomas were benign (WHO grade I) with 18.8% constituting meningiomas of higher grade (WHO II and III). [7] Although SB meningiomas in the adult population are more difficult to treat than NSB meningiomas, specific differences between NSB and SB meningiomas in the pediatric population have not previously been analyzed.…”

Section: Introductionmentioning

confidence: 89%

“…[4,7,8,[11][12][13] A recently published meta-analysis compared for the first time the characteristics of nearly 700 pediatric meningiomas from 35 studies. [6] With regard to the location of these tumors, the incidence of non-skull base (NSB) meningiomas was higher than that of skull base (SB) meningiomas. Approximately 73% were NSB meningiomas (convexity, parasagittal, tentorial, intraventricular or intraparenchymal region)…”

Section: Introductionmentioning

confidence: 99%

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Surgical Resection of Pediatric Skull Base Meningiomas

Burkhardt¹,

Krayenbühl²,

Bernays³

et al. 2012

J Neurol Surg A Cent Eur Neurosurg

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PURPOSE: Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB) meningiomas. METHODS: From our database of 724 surgically treated meningioma patients at the University Hospital, Zurich between 1995 and 2010, 12 patients under 18 years of age were identified. Data for those patients was retrospectively collected through chart review. A descriptive comparison between SB and NSB meningiomas was undertaken to determine statistical significance. RESULTS: In all 12 children (seven males, five females; mean age 12.2 ± 4.3 years), surgical removal of the meningioma was performed microsurgically with a mean follow-up of 53 months (range 12-137 months). Of the 12 tumors, six were located in the SB and six in the NSB. Comparing SB to NSB lesions, the mean age was 11 ± 3.8 versus 14 ± 4.6 years, male/female gender distribution was 5:1 compared to 1:5, mean tumor size was 7.5 ± 6.2 versus 26 ± 15.8 cm(2) (p = 0.03), and mean surgery time was 347 versus 214 min. While WHO grade was similar for both groups, the Simpson grade revealed more extensive resection for NSB meningiomas. The Glasgow Outcome Scale at last follow-up was favorable for both groups. CONCLUSIONS: Meningioma surgery was safe with favorable outcomes. SB meningiomas were significantly smaller in size, were less likely to undergo complete resection, and had a predilection for younger, male patients. Surgical Resection of Pediatric Skull Base Meningiomas Keywords:Pediatric meningiomas, skull base meningioma, neurosurgery, resection 2 AbstractPurpose Meningiomas in children are rare, especially those located at the skull base. In this study, we report our experience of meningioma surgery in the pediatric population and compare our findings of skull base (SB) versus non-skull base (NSB) meningiomas.Methods From our database of 724 surgically-treated meningioma patients at the University Hospital, Zurich between 1995 and 2010, 12 patients under 18 years of age were identified.Data for those patients was retrospectively collected through chart review. A descriptive comparison betweent SB and NSB meningiomas was undertaken to determine statistical significance.Results In all 12 children (7 males, 5 females; mean age 12.2 ± 4.3 years) surgical removal of the meningioma was performed microsurgically with a mean follow-up of 53 months (range 12-137 months). Of the 12 tumors, 6 were located in the SB and 6 in the NSB. Comparing SB to NSB lesions, the mean age was 11 ± 3.8 years versus 14 ± 4.6 years; male:female gender distribution was 5:1 compared to 1:5, mean tumor size was 7.5 ± 6.2 cm 2 versus 26 ± 15.8 cm 2 (p=0.03) and mean surgery time was 347 minutes versus 214 minutes. Whilst WHO grade was similar for both groups, the Simpson grade revealed more extensive resection for NSB meningiomas. The Glasgow outcome scale at last follow up was favorable for both groups.Conclusions...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Surgical Resection of Pediatric Skull Base Meningiomas

Burkhardt¹,

Krayenbühl²,

Bernays³

et al. 2012

J Neurol Surg A Cent Eur Neurosurg

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“…Kadın:erkek oranı 2:1'dir. 2 Toplumda ileri yaş popülasyonundaki artış, çevresel risk faktörlerine giderek daha fazla maruziyet ve ayrıca görüntü-leme yöntemlerindeki ilerlemelerin gelecek pratikte meningiom insidansındaki artışı da beraber getireceğini öngörmek mümkündür. 3 Meningiomların büyük bir çoğunluğu yavaş büyüyen benign tümörler olmalarına karşın, bir kısmı da lokal nüks, kısalmış yaşam süresi, serebrospinal sıvı boyunca yayılma ve nadiren de uzak metastaz gibi malign davranış gösterebilmektedir.…”

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Clinicopathological Assessment in 311 Primary Meningioma Cases and Immunohistochemistrial Analysis with CD147

Canbaz¹

2017

Turkiye Klinikleri J Med Sci

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Ö ÖZ ZE ET T A Am ma aç ç: : Meningiomlar, histolojik derece ve subtiplerine göre değişen oranlarda nüks riskine sahip, erişkin yaş grubunun en sık görülen primer santral sinir sistemi tümörleridir. Çalışmamızda Karadeniz Bölgesinin en büyük üçüncü basamak hastanesinde tanı almış meningiom olgularının klinikopatolojik özelliklerinin gözden geçirilmesi amaçlanmıştır. Ayrıca çeşitli tümörlerde invazyon ve metastaz yeteneği ile ilgili olduğu bildirilen CD147 molekülünün meningiomlardaki ekspresyonunun, histolojik subtip, klinik nüks ve Dünya Sağlık Örgütü (WHO) kriterlerine göre belirlenen tümör derecesi ile ilişkisi incelenmiştir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : 2003-2012 yılları arasında Ondokuz Mayıs Üniversitesi Tıp Fakültesi hastanesinde meningiom tanısı almış 311 olgu klinik ve histopatolojik özellikleri açısından retrospektif olarak değerlendirildi. WHO derecelerine ve klinik takiplerine göre belirlenen 101 olguda CD147 ile immünhistokimyasal çalışma yapıldı. B Bu ul lg gu ul la ar r: : Olgularımızın 223'ü (%71,6) kadın, 88'i (%28,4) erkektir. Yaş dağılımı 8-92 arasında olup ortanca yaş 55 yıldır. 267 olgu (%85,9) derece I, 39 olgu (%12,5) derece II, 5 olgu (%1,6) derece III olarak yorumlanmıştır. Klinik takibine ulaşılabilen olgularda (n=254) nüks oranı %11,4'dür (n=29). İm-münhistokimyasal yöntemle, %73,5 meningiom olgusu CD147 ile pozitif boyanmıştır. CD147 ekspresyonu, WHO derecesinde artış ve nüks açısından anlamlı fark göstermemiştir (sırasıyla p=0,261, p=0,220). S So on nu uç ç: : Meningiom olgu serimiz, demografik veriler, WHO derece dağılımı ve histopatolojik özellikler açısından literatür verileri ile uyumludur. Bazı meningiomlar belirgin CD147 ekspresyonu göstermektedir, ancak bu ekspresyonun agresif histolojik özellikler ve klinik nüks ile anlamlı bir ilişkisi tespit edilememiştir.A An na ah ht ta ar r K Ke el li im me el le er r: : Meningiom; immünohistokimya; antijenler, CD147 A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Meningiomas are the most common tumors of the central nervous system in adults, and have varying degrees of recurrence risk according to WHO (World Health Organization) grade. In this study, our aim is to review the clinical and pathological characteristics of meningiomas, which had been diagnosed in the largest tertiary referral hospital north of Turkey. In addition, investigated CD147 expression in meningiomas, and its association with tumor grade and recurrence. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : The 311 primary meningiomas, diagnosed at the Ondokuz Mayis University Hospital, Department of Pathology between 2003-2012, were studied retrospectively and performed immunohistochemistry with CD147. R Re es su ul lt ts s: : Of 311 meningioma cases, 223 (71.6%) were women and 88 (28.4%) were men. The age ranged from 8 to 92 years (median 55). By histomorphological reevaluation, it was determined that 267 cases (85.9%) were grade I, 39 cases were grade II (12.5%) and 5 cases (1.6%) were grade III. Tumor relapse had occurred in...

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Rare childhood cancers—an increasing entity requiring the need for global consensus and collaboration

et al. 2015

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Rare childhood cancers have not benefited to the same extent from the gains that have been made for their frequently occurring counterparts. In recent years, this gap has been recognized and a number of vehicles now exist to improve outcome, including rare tumor groups, disease-specific registries, and clinics. The multitude of approaches has allowed significant progress, however, this framework is limited by patient number and is not inclusive for every type of rare childhood cancer. These shortcomings can be overcome by a single global unified approach to the study of rare childhood tumors.

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Meningiomas in children and adolescents: a meta-analysis of individual patient data

Cited by 146 publications

References 48 publications

Surgical Resection of Pediatric Skull Base Meningiomas

Surgical Resection of Pediatric Skull Base Meningiomas

Clinicopathological Assessment in 311 Primary Meningioma Cases and Immunohistochemistrial Analysis with CD147

Rare childhood cancers—an increasing entity requiring the need for global consensus and collaboration

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