Meningioma in the pediatric population

Baumgartner, James E.; Sorenson, Jeffrey

doi:10.1007/bf00165652

Cited by 82 publications

(63 citation statements)

References 28 publications

(54 reference statements)

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“…While most pediatric meningiomas are supratentorial and extraventricular, the infratentorial, intraorbital, and intraventricular locations are more commonly seen in children than adults [1, 2, 4, 7,11,12,13]. In our series, 6 patients (30%) had meningiomas in the posterior fossa, orbit, or ventricle.…”

Section: Discussionmentioning

confidence: 78%

“…Modan et al[ 6] studied 11,000 children who had been irradiated for tinea capitis and found a fourfold increased risk of meningioma. The prevalence of NF-2 in pediatric patients with meningioma has been shown to be 25–40% [1, 2,7,8,9,10]. Patients with spontaneously arising meningiomas appear to have tumors distinct from those with radiation-induced meningiomas or those associated with NF-2, in that those patients with spontaneously arising meningiomas were younger at the time of diagnosis, were more likely to be female, and had tumors that were more likely to recur and to be malignant.…”

Section: Discussionmentioning

confidence: 99%

“…Pediatric meningiomas are rare, comprising less than 5% of all pediatric brain tumors and less than 2% of all meningiomas [2,3,4,5]. The female preponderance seen in adult patients is not found in children; the reported male-to-female ratio in children is 1.2:1 [1, 4].…”

Section: Introductionmentioning

confidence: 99%

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Meningiomas in Children

et al. 2007

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Objective: Pediatric meningioma is a rare diagnosis. This retrospective review seeks to elucidate pertinent characteristics of pediatric patients presenting with meningioma. Methods: The Seattle Children’s Hospital and Regional Medical Center brain tumor database was surveyed from 1940 through 2004. Twenty patients were identified. Results: The median age of the 20 patients was 13 years. Five patients had radiation-induced meningiomas. Five patients had neurofibromatosis type 2. Ten patients had spontaneously arising meningiomas, 2 of which were malignant. Conclusion: Patients with spontaneously arising meningiomas were younger than those with identified risk factors. There was no recurrence in patients with radiation-induced meningiomas. The only death occurred in a patient with a malignant meningioma.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

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Meningiomas in Children

et al. 2007

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“…A localização destes tumores nos ventrículos, mais rara nos adultos, é bem mais frequente nas crianças, sendo que cerca de 15 a 17% dos meningiomas na infância se localizam no sistema ventricular, mais comumente no átrio do ventrículo lateral. A teoria mais aceita sobre a origem destas lesões é a de que elas surgem de células meningoteliais do estroma do plexo coróide [1][2][3][4][5][6][11][12][13] .…”

Section: Discussionunclassified

“…No adulto, tais lesões representam cerca de 20% dos tumores intracranianos. A localização intraventricular dos meningiomas é rara, embora na divisão dos casos por faixa etária, seja mais comum em crianças (15 a 17%) do que em adultos (1,6%), sendo os ventrículos laterais a localização mais frequente [1][2][3][4][5][6][7][8][9] …”

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Meningioma do terceiro ventrículo na infância: relato de caso

Costa¹,

Vilela²,

Lemos

2000

Arq. Neuro-Psiquiatr.

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RESUMO -Objetivo: Meningiomas intraventriculares são lesões raras, mais ainda as que acometem o terceiro ventrículo. Na infância, somente 16 casos foram relatados na literatura. Acrescentamos este relato de meningioma da parte anterior do terceiro ventrículo em uma menina, juntamente com breve revisão da literatura. Apresentação e intervenção: Criança previamente hígida, de 5 anos, foi internada com história de vômitos e cefaléa de 2 meses de duração. Ao exame clínico e neurológico, foi notado somente papiledema. Foi realizada tomografia computadorizada de crânio, que mostrou volumosa lesão na linha média supratentorial, ocupando toda a região do terceiro ventrículo, captante, com dilatação ventricular suprajacente. A paciente foi submetida a craniotomia frontal direita, e a lesão totalmente removida através da via transcalosa interfornical. O pós-operatório foi sem intercorrências, e não foi necessária derivação ventricular permanente. Hoje, dois anos e meio após a alta, a criança está em acompanhamento ambulatorial, sem déficits neurológicos, com bom desempenho escolar e sem evidência de recidiva nas tomografias de controle. Conclusão: Meningiomas da parte anterior do terceiro ventrículo são lesões raras na infância. O tratamento cirúrgico dos meningiomas intraventriculares no passado era associado a altas taxas de morbidade e mortalidade. Com o advento das modernas técnicas neuroanestésicas e neurocirúgicas, e do suporte intensivo pós-operatório, atualmente estas lesões podem ser removidas na sua totalidade, com morbidade e mortalidade praticamente nulas. PALAVRAS-CHAVE: infância, meningioma intraventricular, acesso transcaloso.Third ventricle meningioma in a child: case report ABSTRACT -Meningiomas in childhood are rare, and those located in the third ventricle are even rarer, with only 16 cases reported. A five-year-old girl was seen at our hospital with headache and bilateral papilledema. CT scan showed a large third ventricular mass and associated hydrocephalus. Transcallosal interfornical approach was performed with total removal of the tumor, that was attached to the choroid plexus of the anterior third ventricle. Histologically the lesion proved to be a transitional meningioma. The recovery was uneventful, a permanent shunt was not necessary. The diagnosis of these tumors can be done using CT scan or MRI, that usually are sufficient for surgical planning. Angiography usually is not required, unless a vascular lesion is concerned, or embolization is necessary. The treatment of these tumors is surgical, aiming the total removal of the lesion, usually curative once it is acomplished. We report this case, and add a brief review of the literature on third ventricle meningiomas.KEY WORDS: childhood, intraventricular meningioma, transcallosal approach.A incidência de meningiomas intracranianos na infância é cerca de 1,5 a 2,5% de todos os tumores intracranianos nesta faixa etária. No adulto, tais lesões representam cerca de 20% dos tumores intracranianos. A localização intraventricular dos meningiomas é rara,...

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Morbidity in survivors of child and adolescent meningioma

Kotecha

Jacoby

Cole

et al. 2013

Cancer

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BackgroundThe extent of initial surgical resection has been identified as the strongest prognostic indicator for survival in child and adolescent meningioma. Given the paucity of data concerning long-term outcome, the authors undertook a meta-analysis to analyze morbidity in survivors of this disease.MethodsIndividual patient data were obtained from 19 case series published over the last 23 years through direct communication with the authors. Ordinal logistic regression models were used to assess the influence of risk factors on morbidity.ResultsOf 261 patients, 48% reported a completely normal life with no morbidity, and 25% had moderate/severe meningioma-associated morbidity at last follow-up. Multivariate analysis identified relapse as the only independent variable associated with an increased risk of morbidity (odds ratio, 4.02; 95% confidence interval, 2.11-7.65; P ≤ .001). Univariate analysis also revealed an increased risk for patients with neurofibromatosis (odds ratio, 1.90; 95% confidence interval, 1.04-3.48; P = .04). Subgroup analysis identified a higher incidence of morbidity among patients who had intracranial tumors with a skull base location compared with a nonskull base location (P ≤ .001). Timing at which morbidity occurred was available for 70 patients, with persistence of preoperative tumor-related symptoms in 67% and as a result of therapy in 20%.ConclusionsThe majority of survivors of child and adolescent meningioma had no or only mild long-term morbidity, whereas 25% had moderate/severe morbidity, with a significantly increased risk in patients with relapsed disease. In the majority, morbidity occurred as a consequence of the tumor itself, justifying aggressive surgery to achieve gross total resection. However, for patients with neurofibromatosis and skull base meningioma, a more cautious surgical approach should be reserved.

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Meningioma in the pediatric population

Cited by 82 publications

References 28 publications

Meningiomas in Children

Meningiomas in Children

Meningioma do terceiro ventrículo na infância: relato de caso

Morbidity in survivors of child and adolescent meningioma

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