Meningioma in children: A report of nine cases and review of the literature

Sheikh, Bassem Y.; Siqueira, Edir B.; Dayel, Fouad Al

doi:10.1016/0090-3019(95)00451-3

Cited by 67 publications

(64 citation statements)

References 62 publications

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“…La incidencia de meningioma en las edades pediátricas oscilaba entre el 1.1% al 4.5% de todos los tumores pediátricos intervenidos 1,4,5,8,10,11 ; mientras que del global de los meningiomas intervenidos representaban tan sólo entre el 1.08% al 3.3% 1,5,10 . Las series revisadas fueron series de pacientes en edades pediátricas pero el rango de edades variaba, puesto que en función del centro se consideraron hasta los 15 ó hasta los 20 años, hecho que implicaba un aumento en la incidencia en estas últimas 3 .…”

Section: Epidemiologíaunclassified

“…Las series revisadas fueron series de pacientes en edades pediátricas pero el rango de edades variaba, puesto que en función del centro se consideraron hasta los 15 ó hasta los 20 años, hecho que implicaba un aumento en la incidencia en estas últimas 3 . Se contabilizaron, junto con nuestra serie un total de 76 varones frente a las 68 mujeres entre todas las series 1,4,5,6,8,10,11 , resultando una razón (varones/mujeres) de 1,11. Resultó mínima la mayor incidencia en estas edades en los varones, contrastando notablemente con la clara afectación en las mujeres en las edades más adultas.…”

Section: Epidemiologíaunclassified

“…De la serie 1,4,8,10,11 propia, donde se pudo objetivar edad y sexo destacamos un predominio en varones en edades más tempranas con tendencia a equilibrarse entre los 6 y los 10 años, para finalmente aumentar la incidencia en el sexo femenino. (Tabla 4).…”

Section: Epidemiologíaunclassified

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El meningioma en edad pediátrica: Revisión de 10 casos

Teixidor

Guillén²,

Cruz³

et al. 2008

Neurocirugía

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Recibido:434 Neurocirugía 2008; 19: Resumen La presencia de meningiomas en la edad pediátrica es relativamente rara, representan menos del 5% de todos los tumores del sistema nervioso central en este estadio de la vida.Hemos realizado un estudio retrospectivo de 10 casos de meningiomas en pacientes pediátricos analizando los factores epidemiológicos, clínicos y radiológicos, así como el pronóstico a largo plazo de nuestros pacientes. Los resultados se comparan con aquéllos reportados en la literatura.PALABRAS CLAVE: Meningioma. Neoplasia. Sistema nervioso central. Pediatría. Intracranial meningiomas in children: report of 10 cases SummaryThe occurrence of meningiomas in children is rare, accounting for less than 5% of tumors of the central nervous system in childhood. This is a retrospective study of 10 patients with CNS meningiomas. The goal of this study was to determine the epidemiology, clinical and radiological features, and long-term outcome of meningiomas The results ware compared with those reported in the literature.

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Section: Epidemiologíaunclassified

See 1 more Smart Citation

El meningioma en edad pediátrica: Revisión de 10 casos

Teixidor

Guillén²,

Cruz³

et al. 2008

Neurocirugía

View full text Add to dashboard Cite

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“…Características radiológicas -Exames radiográficos simples de crânio podem revelar abaulamentos da caixa craniana, bem como calcificações intratumorais 11,18,22 , fato observado no caso 2. A tomografia computadorizada permite boa visualização do tumor; contudo, apresenta limitação nos tumores de fossa posterior [23][24][25][26][27] .…”

Section: 21unclassified

“…Entretanto, Sheikh e cols. 11 consideram os meningiomas em crianças como lesões propensas a crescimento rápido, transformação maligna e taxas de recorrência elevadas. Os fatores que determinam a taxa de sobrevida nesta população são ainda discutidos.…”

Section: 21unclassified

Meningiomas em pacientes pediátricos: relato de 2 casos

Hanel

Tatsui

Araújo

et al. 2001

Arq. Neuro-Psiquiatr.

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RESUMO -Os meningiomas correspondem de 1% a 4% das neoplasias intracranianas primárias em pacientes pediátricos; a incidência nesta população aumenta de acordo com a faixa etária. Não há predominância quanto ao sexo, ao contrário do que acontece na população adulta onde predominam no sexo feminino. Relatamos dois casos de meningioma em crianças, discutindo os aspectos clínicos, radiológicos e histológicos desta entidade. O primeiro paciente é do sexo masculino, com 2 anos de idade e apresentava com crises convulsivas há 4 meses. Os exames de imagem revelaram uma lesão expansiva de 20 mm na região parietooccipital direita, a qual foi totalmente ressecada. Os exames histológico e imunohistoquímico definiram o diagnóstico de meningioma. Atualmente, 17 meses após a cirurgia, o paciente encontra-se bem, sem evidências de recidiva tumoral. O segundo paciente é do sexo feminino, com 11 anos, e queixava-se de cefaléia frontal há 2 anos. Os exames radiológicos demonstraram presença de lesão expansiva de 5 cm em região frontal direita. Realizou-se craniotomia frontal com ressecção total do tumor. O diagnóstico histológico foi de meningioma. Atualmente, 20 meses após a cirurgia, encontra-se sem evidência de recidiva tumoral. Os autores discutem ainda o tratamento e prognóstico dos meningiomas pediátricos ressaltando que apesar de incomuns, estes devem fazer parte do diagnóstico diferencial de lesões intracranianas expansivas nesta faixa etária. PALAVRAS-CHAVE: meningioma, crianças, sistema nervoso central. Meningiomas in pediatric patients: report of two casesABSTRACT -Meningiomas correspond to 1% -4% of primary intracranial tumors in pediatric group, with their incidence raising according to age. There is not gender prevalence, in spite of some authors describe a male tendency opposed to female one in adulthood. At present study we describe two cases of pediatric meningiomas reviewing clinical, radiological and histological aspects of these lesions. The authors review also treatment options and prognosis of childhood meningiomas. A two-year-old boy was admitted with seizures. Computerized tomography showed a right parietal lesion, which was totally resected. Histological features were compatible with meningioma. After 17 months the child is doing well, with no deficits or seizures. The second case is a 12-year-old girl, with a headache complain. During investigation, a CT revealed a right frontal lesion. She was operated under a right frontal craniotomy with total tumor resection. Nowadays she is asymptomatic, 20 months after surgery. Despite meningiomas in pediatric group are uncommon; they should be included in differential diagnosis list of expansive intracranial lesions of childhood.

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Morbidity in survivors of child and adolescent meningioma

Kotecha

Jacoby

Cole

et al. 2013

Cancer

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BackgroundThe extent of initial surgical resection has been identified as the strongest prognostic indicator for survival in child and adolescent meningioma. Given the paucity of data concerning long-term outcome, the authors undertook a meta-analysis to analyze morbidity in survivors of this disease.MethodsIndividual patient data were obtained from 19 case series published over the last 23 years through direct communication with the authors. Ordinal logistic regression models were used to assess the influence of risk factors on morbidity.ResultsOf 261 patients, 48% reported a completely normal life with no morbidity, and 25% had moderate/severe meningioma-associated morbidity at last follow-up. Multivariate analysis identified relapse as the only independent variable associated with an increased risk of morbidity (odds ratio, 4.02; 95% confidence interval, 2.11-7.65; P ≤ .001). Univariate analysis also revealed an increased risk for patients with neurofibromatosis (odds ratio, 1.90; 95% confidence interval, 1.04-3.48; P = .04). Subgroup analysis identified a higher incidence of morbidity among patients who had intracranial tumors with a skull base location compared with a nonskull base location (P ≤ .001). Timing at which morbidity occurred was available for 70 patients, with persistence of preoperative tumor-related symptoms in 67% and as a result of therapy in 20%.ConclusionsThe majority of survivors of child and adolescent meningioma had no or only mild long-term morbidity, whereas 25% had moderate/severe morbidity, with a significantly increased risk in patients with relapsed disease. In the majority, morbidity occurred as a consequence of the tumor itself, justifying aggressive surgery to achieve gross total resection. However, for patients with neurofibromatosis and skull base meningioma, a more cautious surgical approach should be reserved.

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Meningioma in children: A report of nine cases and review of the literature

Cited by 67 publications

References 62 publications

El meningioma en edad pediátrica: Revisión de 10 casos

El meningioma en edad pediátrica: Revisión de 10 casos

Meningiomas em pacientes pediátricos: relato de 2 casos

Morbidity in survivors of child and adolescent meningioma

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