Meningioma grading based on positron emission tomography: A systematic review and meta-analysis

Filis, Panagiotis; Alexiou, George Α.; Zigouris, Andreas; Sioka, Chrissa; Filis, Nikolaos; Voulgaris, Spyridon

doi:10.1016/j.wnsx.2023.100167

Cited by 2 publications

(2 citation statements)

References 38 publications

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“… 9 Furthermore, 18 F-FLT accumulation in one of our SEGA cases significantly surpassed that reported for meningiomas, potentially serving as a point for differentiation. 8 , 10 Both our SEGA cases exhibited 11 C-MET T/N ratios similar to those of CN, and the case with multiple tracers also showed a similar 18 F-FDG T/N ratio, indicating minimal accumulation. 11 …”

Section: Discussionsupporting

confidence: 56%

“…To provide a broader context, we compared SEGA with other benign tumors that exhibit similar imaging characteristics, namely meningiomas and CNs. Our findings suggest that 18 F-FDG uptake in SEGA resembles that of low-grade meningiomas, 7 , 8 whereas 11 C-MET accumulates regardless of malignancy grade in meningiomas. 9 Furthermore, 18 F-FLT accumulation in one of our SEGA cases significantly surpassed that reported for meningiomas, potentially serving as a point for differentiation.…”

Section: Discussionmentioning

confidence: 61%

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Revealing subependymal giant cell astrocytoma with multimodal positron emission tomography: illustrative cases

Kawai,

Ogawa,

Fuke

et al. 2024

J Cosmet Laser Ther

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BACKGROUND There is limited literature on the use of positron emission tomography (PET) for benign tumors originating in the brain ventricles, and the use of multiple tracers for subependymal giant cell astrocytoma (SEGA) has not been reported. The authors compared the PET findings in two SEGA cases with past reports and literature, exploring the distinctive characteristics of SEGA on PET. OBSERVATIONS In a 21-year-old female with SEGA, the authors utilized 18F-fluorodeoxyglucose (18F-FDG), 11C-methionine (11C-MET), 18F-fluorothymidine (18F-FLT), 18F-fluoromisonidazole, and 18F-THK5351 tracers. Additionally, in a 6-year-old girl, the authors performed 11C-MET PET. LESSONS The results indicated the accumulation of all tracers except 18F-FDG, with particularly intense accumulation noted with 18F-FLT. In particular, 18F-FLT demonstrated accumulation comparable to that observed in malignant tumors. This study suggests that multiple PET tracers can provide valuable insights into the characterization of SEGA, with 18F-FLT showing particular promise as a distinctive marker of blood-brain barrier disruption. Further research in larger cohorts may enhance our understanding of metabolic patterns in SEGA and aid in its diagnosis and treatment. https://thejns.org/doi/10.3171/CASE24111

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 61%

Revealing subependymal giant cell astrocytoma with multimodal positron emission tomography: illustrative cases

Kawai,

Ogawa,

Fuke

et al. 2024

J Cosmet Laser Ther

View full text Add to dashboard Cite

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Chronic hyperglycemia and intracranial meningiomas

Orešković,

Madero Pohlen,

Cvitković

et al. 2024

BMC Cancer

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Meningiomas are among the most common primary tumors of the central nervous system. Previous research into the meningioma histological appearance, genetic markers, transcriptome and epigenetic landscape has revealed that benign meningiomas significantly differ in their glucose metabolism compared to aggressive lesions. However, a correlation between the systemic glucose metabolism and the metabolism of the tumor hasn’t yet been found. We hypothesized that chronic levels of glycaemia (approximated with glycated hemoglobin (HbA1c)) are different in patients with aggressive and benign meningiomas. The study encompassed 71 patients with de novo intracranial meningiomas, operated on in three European hospitals, two in Croatia and one in Spain. Our results show that patients with WHO grade 2 meningiomas had significantly higher HbA1c values compared to patients with grade 1 lesions (P = 0.0290). We also found a significant number of patients (19/71; 26.7%) being hyperglycemic, harboring all the risks that such a condition entails. Finally, we found a significant correlation between our patients’ age and their preoperative HbA1c levels (P = 0.0008, ρ(rho) = 0.388), suggesting that older meningioma patients are at a higher risk of having their glycaemia severely dysregulated. These findings are especially important considering the current routine and wide-spread use of corticosteroids as anti-edematous treatment. Further research in this area could lead to better understanding of meningiomas and have immediate clinical impact.

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Meningioma grading based on positron emission tomography: A systematic review and meta-analysis

Cited by 2 publications

References 38 publications

Revealing subependymal giant cell astrocytoma with multimodal positron emission tomography: illustrative cases

Revealing subependymal giant cell astrocytoma with multimodal positron emission tomography: illustrative cases

Chronic hyperglycemia and intracranial meningiomas

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