Meningioma associated with McCune-Albright syndrome

Abstract

Fig. 1 Typical, unilaterally distributed hyperpigmented macules in McCune-Albright syndrome. Insert spinal meningioma (arrow) on T1-weighted magnetic resonance imaging Hamm, Department of Dermatology, University of Würzburg, for the careful reading of the manuscript and his valuable suggestions, Prof. L. Solymosi, Division of Neuroradiology, University of Würzburg, for providing the MRI films, Prof. W. Roggendorf, Division of Neuropathology, University of Würzburg, for reading the pathology slides, and Prof. J. Meixensberger, Department of Neurosurgery, University of Würzburg, for information on the operation. A. Bayas (౧) · M. Naumann ·

Onyx embolization of an intraosseous pseudoaneurysm of the middle meningeal artery in a patient with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome

“…33 There are only 2 case reports of meningiomas arising in association with MAS. 4,8 A report of an orbital and palpebral arteriovenous malformation was described in a patient with MAS; 32 however, vascular anomalies are not associated features of MAS. There are several reports of aneurysmal bone cysts forming in the setting of fibrous dysplasia; 10,21 however, the imaging and angiographic appearance in this case was not that of an aneurysmal bone cyst.…”

Co-existing fibrous dysplasia and meningothelial meningioma

“…Monostotic form involves the skull and facial bones in 10-25% and polyostotic in 50% cases. Fibrous dysplasia can be present as one of the components of McCune-Albright syndrome 1,2,3,7 . Approximately one-third of patients with dysplasia fibrous has involvement of cranial and face bones.…”

“…A search at "PubMed" (U.S. National Library of Medicine) with terms "fibrous", "dysplasia" and "meningioma" demonstrated a total of 7 cases reported. Three cases in association with McCune-Albright syndrome 2,3 , two cases in the Chinese literature 4 , one case with multiple globoid meningiomas with craniomandibular fibrous dysplasia 5 , and one reported case of atypical lymphoplasmacyte-rich meningioma 1 . To the best of our knowledge, this is the first reported case of co-existing fibrous dysplasia and meningothelial meningioma with histopathological diagnosis 1,6,7 .…”

Gigantism Treated by Pure Endoscopic Endonasal Approach in a Case of McCune-Albright Syndrome with Sphenoid Fibrous Dysplasia: A Case Report

“…different hormone secreting (prolactin [PRL]-, growth hormone [GH]-, PRL-GH-, thyroid-stimulating hormone [TSH]-, and adrenocorticotropic hormone [ACTH]) pituitary adenomas , precocious puberty, adrenal primary hyperplasia, hypophosphatemic rickets/osteomalacia, and even ovarian cysts. 2,6,11,[14][15][16] Secreting üituitary adenomas are reported in association with more than 50% of the MAS cases. 14 As well as endocrinologic disorders, fibrous dysplastic bone changes in MAS occur in various forms, such as expansions, cystic lesions, and fibrous thickening that, quite unlike the sclerotic tissues, have an active vascular network in the interior.…”

“…[1][2][3][4][5][6] MAS results from mosaic G protein α-subunit (GNAS)-activating mutations. Postzygotic mutation in the GNAS gene activates G protein, cyclic adenosine monophosphate (cAMP), and the adenylate cyclase pathway, resulting in a mosaic population of cells that affect multiple organ systems by various pathogeneses.…”