Meningeal Lymphatics: An Immune Gateway for the Central Nervous System

Tavares, Gabriel Araújo; Louveau, Antoine

doi:10.3390/cells10123385

Cited by 32 publications

(22 citation statements)

References 72 publications

(143 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The numbers of transgene‐carrying cells decreased with time in the lesion and perilesional areas, which could be explained by the fact that immune cells infiltrating CNS have been reported to eventually undergo apoptosis (Pender et al , 1991 ), or because these cells simply leave via defined lymphatic channels (Tavares & Louveau, 2021 ). Interestingly, we did observe the persistence of some GFP + cells in the lesions and perilesional tissue at 60 dpl, which is consistent with the reports that busulfan preconditioning increases CNS engraftment of blood myeloid cells (Capotondo et al , 2012 ; Sailor et al , 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Genetically modified macrophages accelerate myelin repair

Aigrot

Barthelemy

Moyon³

et al. 2022

EMBO Mol Med

View full text Add to dashboard Cite

Preventing neurodegeneration-associated disability progression in patients with multiple sclerosis (MS) remains an unmet therapeutic need. As remyelination prevents axonal degeneration, promoting this process in patients might enhance neuroprotection. In demyelinating mouse lesions, local overexpression of semaphorin 3F (Sema3F), an oligodendrocyte progenitor cell (OPC) attractant, increases remyelination. However, molecular targeting to MS lesions is a challenge. A clinically relevant paradigm for delivering Sema3F to demyelinating lesions could be to use blood-derived macrophages as vehicles. Thus, we chose transplantation of genetically modified hematopoietic stem cells (HSCs) as means of obtaining chimeric mice with circulating Sema3F-overexpressing monocytes. We demonstrated that Sema3F-transduced HSCs stimulate OPC migration in a neuropilin 2 (Nrp2, Sema3F receptor)-dependent fashion, which was conserved in middle-aged OPCs. While demyelinating lesions induced in mice with Sema3F-expressing blood cells showed no changes in inflammation and OPC survival, OPC recruitment was enhanced which accelerated the onset of remyelination. Our results provide a proof of concept that blood cells, particularly monocytes/macrophages, can be used to deliver pro-remyelinating agents "at the right time and place," suggesting novel means for remyelination-promoting strategies in MS.

show abstract

Section: Discussionmentioning

confidence: 99%

Genetically modified macrophages accelerate myelin repair

Aigrot

Barthelemy

Moyon³

et al. 2022

EMBO Mol Med

View full text Add to dashboard Cite

show abstract

“…It was long thought that tumor cells traveled through the bloodstream to reach the brain and spinal cord [ 38 ]. While this is true, the recently found dural lymphatic system represents an alternative route of lymphocyte trafficking, and it appears that ALL cells may hijack the CNS lympha system to exit or enter the CNS [ 39 ]. This may be a promising new area of study with huge potential clinical applications.…”

Section: Pathogenesis Of Brain Tumormentioning

confidence: 99%

Customizing delivery nano-vehicles for precise brain tumor therapy

et al. 2023

View full text Add to dashboard Cite

Although some tumor has become a curable disease for many patients, involvement of the central nervous system (CNS) is still a major concern. The blood–brain barrier (BBB), a special structure in the CNS, protects the brain from bloodborne pathogens via its excellent barrier properties and hinders new drug development for brain tumor. Recent breakthroughs in nanotechnology have resulted in various nanovehicless (NPs) as drug carriers to cross the BBB by different strategys. Here, the complex compositions and special characteristics of causes of brain tumor formation and BBB are elucidated exhaustively. Additionally, versatile drug nanovehicles with their recent applications and their pathways on different drug delivery strategies to overcome the BBB obstacle for anti-brain tumor are briefly discussed. Customizing nanoparticles for brain tumor treatments is proposed to improve the efficacy of brain tumor treatments via drug delivery from the gut to the brain. This review provides a broad perspective on customizing delivery nano-vehicles characteristics facilitate drug distribution across the brain and pave the way for the creation of innovative nanotechnology-based nanomaterials for brain tumor treatments.

show abstract

“…This lymphatic drainage allows for constant immune surveillance through the flow of CSF antigens and immune cells. In the healthy CNS, this allows for self-tolerance of brain-derived antigens; however, during neuroinflammation, this allows for antigen presenting cells and circulating T cells to relay inflammatory information to the periphery during tissue damage or innate immunity activation [ 40 , 41 ]. This migration of immune cells to the draining lymphatics occurs in a CCR7-dependent manner, that is enhanced during immune activation [ 40 – 42 ].…”

Section: Anatomy and Function Of The Choroid Plexusmentioning

confidence: 99%

The choroid plexus and its role in the pathogenesis of neurological infections

Thompson

Brissette

Watt

2022

Fluids Barriers CNS

View full text Add to dashboard Cite

The choroid plexus is situated at an anatomically and functionally important interface within the ventricles of the brain, forming the blood-cerebrospinal fluid barrier that separates the periphery from the central nervous system. In contrast to the blood–brain barrier, the choroid plexus and its epithelial barrier have received considerably less attention. As the main producer of cerebrospinal fluid, the secretory functions of the epithelial cells aid in the maintenance of CNS homeostasis and are capable of relaying inflammatory signals to the brain. The choroid plexus acts as an immunological niche where several types of peripheral immune cells can be found within the stroma including dendritic cells, macrophages, and T cells. Including the epithelia cells, these cells perform immunosurveillance, detecting pathogens and changes in the cytokine milieu. As such, their activation leads to the release of homing molecules to induce chemotaxis of circulating immune cells, driving an immune response at the choroid plexus. Research into the barrier properties have shown how inflammation can alter the structural junctions and promote increased bidirectional transmigration of cells and pathogens. The goal of this review is to highlight our foundational knowledge of the choroid plexus and discuss how recent research has shifted our understanding towards viewing the choroid plexus as a highly dynamic and important contributor to the pathogenesis of neurological infections. With the emergence of several high-profile diseases, including ZIKA and SARS-CoV-2, this review provides a pertinent update on the cellular response of the choroid plexus to these diseases. Historically, pharmacological interventions of CNS disorders have proven difficult to develop, however, a greater focus on the role of the choroid plexus in driving these disorders would provide for novel targets and routes for therapeutics.

show abstract

Meningeal Lymphatics: An Immune Gateway for the Central Nervous System

Cited by 32 publications

References 72 publications

Genetically modified macrophages accelerate myelin repair

Genetically modified macrophages accelerate myelin repair

Customizing delivery nano-vehicles for precise brain tumor therapy

The choroid plexus and its role in the pathogenesis of neurological infections

Contact Info

Product

Resources

About