Meningeal carcinomatosis from an ovarian primary: A clinicopathologic study

Behnam, Kazem; Aguilera, Arnold J.; Kornfeld, Mario; Jordan, Scott W.; Hilgers, Robert D.

doi:10.1016/0090-8258(84)90165-3

Cited by 14 publications

(9 citation statements)

References 9 publications

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“…B MRI scan with contrast medium after treatment showed complete disappearance of the meningeal lesion mated that the incidence could be 0.08%-0.28% [2% (CNS metastases) ϫ 4%-14% (proportion of meningeal carcinomatosis in CNS metastases)] of all ovarian carcinomas, on the basis of the recent reviews of Cormio et al 2 and Ross et al 6 Cormio et al 2 described only six patients with meningeal carcinomatosis from ovarian carcinoma in a review of 12 clinical series from the literature. According to our MEDLINE search from 1976 to 1999, only one Japanese 8 and 11 reports from other countries [1][2][3]6,[9][10][11][12][13][14][15] were published related to leptomeningeal carcinomatosis from ovarian carcinoma ( Table 1). …”

Section: Discussionmentioning

confidence: 99%

Meningeal carcinomatosis from an ovarian primary with complete response to adjuvant chemotherapy after cranial irradiation

et al. 2001

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Meningeal metastasis is rare in the clinical course of ovarian carcinoma, and its prognosis is poor. Meningeal dissemination of carcinoma is usually treated by intrathecal administration of methotrexate and total brain irradiation, although these treatments are usually ineffective. We experienced a case of meningeal relapse from ovarian carcinoma resistant to multiple antineoplastic agents in a 64-year-old woman who was treated with eight different chemotherapy regimens after her initial operation 7 years previously. Intrathecal administrations of methotrexate or cisplatin with dexamethasone were not effective. Fifty-Gy whole cranial irradiation inhibited increases in serum carbohydrate antigen (CA) 125 levels and further tumor growth. Adjuvant chemotherapy was required to alleviate frequent headaches and to decrease serum CA125 level and tumor size. Intravenous administration of 45 mg paclitaxel and 35 mg cisplatin, and oral administration of 50 mg etoposide were carried out for 5 days. This treatment was repeated every 3 weeks. After four courses of treatment, meningeal carcinomatosis was not detectable on computed tomography (CT) and magnetic resonance imaging (MRI) scans. The patient's serum levels of CA125 rapidly fell to beneath normal limits and remained normal. She is still alive and clinically free of recurrence 4 months after the last cycle of chemotherapy. As well as reporting our experience with this case, we also present a review of the literature on meningeal carcinomatosis from ovarian cancer.

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Section: Discussionmentioning

confidence: 99%

Meningeal carcinomatosis from an ovarian primary with complete response to adjuvant chemotherapy after cranial irradiation

et al. 2001

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“…Imaging demonstrated bilateral auditory canal metastases with a mass extending to the right cerebellopontine angle as well as several spinal lesions with leptomeningeal involvement ( 5 ). Behnam et al ( 9 ) described a similar rapidly progressive case in a 55-year-old female who, despite appropriate surgical intervention and adjuvant therapies for stage III serous ovarian carcinoma, developed acute onset paraparesis attributable to diffuse cranial and spinal leptomeningeal disease found on autopsy. Similarly, Miller et al ( 11 ) reported a 49-year-old female who developed headache, vertigo, diplopia, seizures, and ataxia five months following initial diagnosis, with imaging demonstrating diffuse cranial and spinal leptomeningeal disease.…”

Section: Discussionmentioning

confidence: 99%

“…Leptomeningeal carcinomatosis is defined as the invasion of cancer cells into the cerebrospinal fluid with subsequent seeding of the leptomeninges. Leptomeningeal carcinomatosis, also known as neoplastic meningitis, has been reported in 5–15% of patients with lymphoma and leukemia, 1–5% of patients with solid tumors, and 1–2% of patients with primary intracranial tumors ( 9 – 11 ). Solid tumors with the highest incidence of leptomeningeal dissemination include breast, lung, and melanoma ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

“…Ovarian metastases to the brain are a known phenomenon, although they represent less than 2% of cases ( 3 – 8 ). Moreover, leptomeningeal seeding of ovarian carcinoma is an exceedingly rare entity with most cases published as case series or individual case reports ( 5 , 9 – 11 ). As such, the literature on the natural history and effective treatment strategies of this phenomenon remains sparse.…”

Section: Introductionmentioning

confidence: 99%

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Iatrogenic Leptomeningeal Carcinomatosis Following Craniotomy for Resection of Metastatic Serous Ovarian Carcinoma: A Systematic Literature Review and Case Report

et al. 2022

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Metastasis of ovarian carcinoma to the central nervous system occurs in <2% of cases and classically localizes within the brain parenchyma. Moreover, leptomeningeal spread of these tumors is an exceedingly rare phenomenon. Here, we conduct a systematic review of the current literature on the natural history, treatment options, and proposed pathogenic mechanisms of leptomeningeal carcinomatosis in ovarian carcinoma. We also report a case of a 67-year-old female with stage IV metastatic ovarian serous carcinoma initially confined to the peritoneal cavity with a stable disease burden over the course of three years. Follow-up imaging demonstrated an intracranial lesion, which was resected via craniotomy, and pathology was consistent with the original diagnosis. Three months after surgery, she developed rapidly progressive dizziness, generalized weakness, fatigue, and ataxia. Repeat MRI demonstrated interval development of extensive and diffusely enhancing dural nodularity, numerous avidly enhancing supratentorial and infratentorial lesions, enhancement of the bilateral trigeminal nerves, internal auditory canals, and exit wound from the surgical site into the posterior aspect of the right-sided neck musculature consistent with diffuse leptomeningeal dissemination. The present case highlights that leptomeningeal dissemination of ovarian carcinoma is a potential yet rare consequence following surgical resection of an ovarian parenchymal metastasis. Progressive clinical symptomatology that develops postoperatively in this patient population should prompt urgent workup to rule out leptomeningeal disease and an expedited radiation oncology consultation if identified.

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“…This complication is still rare in nonhematologic malignancies. It has been reported with most nonhematologic tumors including the following: ovarian malignancies [12], breast cancer [4][5][6][7][8][9], Ewing's sarcoma [13], pleural mesothelioma [14], lung cancer [4][5][6][7][8][9], malignant melanoma [4,7], head and neck cancer [4], stomach cancer [5,8], pancreatic cancer [8], prostatic cancer [8,15], cardioesophageal junction and esophageal cancers [8], maxillary sinus cancer [8], squamous cell carcinoma of the skin [5], adenocarcinoma of unknown primary [4][5][6], carcinoid tumors [16,17], transitional cell carcinoma of the ureter [9], and squamous cell carcinoma of the vagina [9].…”

Section: Discussionmentioning

confidence: 99%

Carcinomatous meningitis from transitional cell carcinoma of the bladder: Case report

et al. 1989

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In the past decade, there has been an increasing awareness of central nervous system metastases as a frequent complication of some malignancies, particularly in lung, breast and hematologic cancers. However, the central nervous system remains an uncommon location for metastases from certain primary tumors including those from the genitourinary system. We report on a patient with transitional cell carcinoma of the bladder who was treated with combination chemotherapy, and during the course of his disease developed carcinomatous meningitis. We anticipate this unusual complication of bladder transitional cell carcinoma will be seen more frequently, especially in the light of available data from effective chemotherapeutic regimens. We report this patient to alert physicians to this complication and to consider using prophylactic measures in responding patients as is the case in other malignancies.

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Meningeal carcinomatosis from an ovarian primary: A clinicopathologic study

Cited by 14 publications

References 9 publications

Meningeal carcinomatosis from an ovarian primary with complete response to adjuvant chemotherapy after cranial irradiation

Meningeal carcinomatosis from an ovarian primary with complete response to adjuvant chemotherapy after cranial irradiation

Iatrogenic Leptomeningeal Carcinomatosis Following Craniotomy for Resection of Metastatic Serous Ovarian Carcinoma: A Systematic Literature Review and Case Report

Carcinomatous meningitis from transitional cell carcinoma of the bladder: Case report

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