Mendelian segregation and high recombination rates facilitate genetic analyses inCryptosporidium parvum
Abigail Kimball,
Lisa Funkhouser-Jones,
Wanyi Huang
et al.
Abstract:Despite the essentiality of sex in the life cycle, very little is known about the process of meiosis in Cryptosporidium. Most in vitro cell lines only support asexual growth of Cryptosporidium parvum (C. parvum), but stem cell derived intestinal epithelial cells grown under air-liquid interface (ALI) conditions support the sexual cycle. To examine chromosomal dynamics during meiosis in C. parvum, we generated two transgenic lines of parasites that were fluorescently tagged with mCherry or GFP on chromosomes 1 … Show more
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