Mendelian Randomization Studies of Coffee and Caffeine Consumption

Cornelis, Marilyn C.; Munafò, Marcus R

doi:10.3390/nu10101343

Cited by 67 publications

(48 citation statements)

References 74 publications

(130 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To the best of our knowledge, this is the first study applying the MR approach to investigate the potential causal association of coffee consumption and risk of stroke. 27 Our study suggests that coffee consumption is not causally associated with stroke, ICH, IS, LV-IS, or CE-IS. However, we found weak evidence of a potential protective effect of coffee consumption on the risk of SV-IS, although the association did not reach statistical significance after correction for multiple comparisons.…”

Section: Discussionmentioning

confidence: 51%

Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study

Huang

et al. 2020

Annals of Neurology

View full text Add to dashboard Cite

Objective Observational epidemiological studies have reported a relationship between coffee intake and risk of stroke. However, evidence for this association is inconsistent, and it remains uncertain whether the association is causal or due to confounding or reverse causality. To clarify this relationship, we adopted a Mendelian randomization (MR) approach to evaluate the effects of coffee consumption on the risk of stroke and its subtypes. Methods A meta‐analysis of genome‐wide association studies (GWASs) including 91,462 coffee consumers was used to identify instruments for coffee consumption. Summary‐level data for stroke, intracerebral hemorrhage, ischemic stroke (IS), and IS subtypes were obtained from GWAS meta‐analyses conducted by the MEGASTROKE consortium. MR analyses were performed using the inverse‐variance‐weighted, weighted‐median, MR‐PRESSO (Pleiotropy RESidual Sum and Outlier) test and MR‐Egger regression. Sensitivity analyses were further performed using alternative instruments to test the robustness of our findings. Results Genetically predicted coffee consumption (high vs infrequent/no) was not associated with risk of stroke. Similarly, among coffee consumers, MR analysis did not indicate causal associations between coffee consumption (cups/day) and risk of stroke. However, in the subgroup analysis, we found weak suggestive evidence for a potential protective effect of coffee consumption on risk of small vessel (SV)‐IS, although the association did not reach statistical significance after correction for multiple comparisons. Interpretation This study suggests that coffee consumption is not causally associated with risk of stroke or its subtypes. Further studies are warranted to elucidate the possible association between coffee intake and risk of SV‐IS, as well as its potential underlying mechanisms. ANN NEUROL 2020;87:525–532

show abstract

Section: Discussionmentioning

confidence: 51%

Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study

Huang

et al. 2020

Annals of Neurology

View full text Add to dashboard Cite

show abstract

“…[ 104 ] An overview of 15 Mendelian randomization studies of coffee and caffeine consumption has recently been published. [ 105 ] Alternatively, metabolomics approaches that measure levels of coffee metabolites in biofluids have provided valuable insights into exposure to coffee constituents in relation to individual health outcomes. [ 103 ] Examining differences in metabolic profiles between various subgroups will contribute to our knowledge of inter‐individual variability in response to coffee consumption.…”

Section: Discussionmentioning

confidence: 99%

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

Visser

Geleijnse

Roos

2020

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope: Coffee is associated with a lower risk of cancer, cardiovascular disease, and type 2 diabetes at the population level. However, individual susceptibility to the effects of coffee consumption will cause heterogeneity in health responses between individuals. In this critical review determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption are systematically evaluated. Methods and results: Embase and MEDLINE are searched for observational studies and clinical trials that examined variation in the response to coffee consumption. A total of 74 studies meet the inclusion criteria, which report variation in cancer (n = 24) and cardiometabolic health (n = 50) outcomes. The qualitative analysis shows that sex, BMI, smoking, alcohol intake, menopausal status, and genetic polymorphisms are probable or possible determinants of inter-individual variability in cancer and cardiometabolic health outcomes in response to coffee and caffeine consumption, albeit the majority of studies have insufficient statistical power to detect significant interaction between these factors and coffee consumption. Conclusion: Several genetic and non-genetic determinants of inter-individual variability in the responses to coffee and caffeine consumption are identified, indicating that some of the health benefits of coffee may only occur in a subgroup of subjects.

show abstract

“…Caffeine (1,3,7-trimethylxanthine) is a natural alkaloid belonging to the family of methylxantines [23][24][25][26][27][28][29][30][31]. The main caffeine sources are tea leaves, cola nuts, and coffee and cocoa beans [23][24][25][26][27][28][29][30][31][32].…”

Section: Caffeinementioning

confidence: 99%

“…Nonetheless, it is among the most frequently consumed substances, with an average daily ingestion of 120 mg [23][24][25][26][27][28][29][30][31][32]. It is present in beverages (e.g., coffee, tea, soft drinks, and energy drinks), food (e.g., cocoa and chocolate) [23][24][25][26][27][28][29][30][31][32], and some stimulants and is used as an adjuvant to increase the absorption of some medications [23][24][25][26][27][28][29][30][31]. Studies show that coffee (60%-75%) and tea (15%-30%) are the main sources of caffeine for adults, while among children, chocolate and soft drinks are the major intake sources [30][31][32] (Figure 3).…”

Section: Caffeinementioning

confidence: 99%

Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition

Guillán-Fresco

Franco-Trepat

Alonso-Pérez

et al. 2020

JCM

View full text Add to dashboard Cite

Osteoarthritis (OA), the most common chronic rheumatic disease, is mainly characterized by a progressive degradation of the hyaline articular cartilage, which is essential for correct joint function, lubrication, and resistance. Articular cartilage disturbances lead to joint failure, pain, and disability. Hyaline cartilage is also present in the growth plate and plays a key role in longitudinal bone growth. Alterations of this cartilage by diverse pathologies have been related to longitudinal bone growth inhibition (LBGI), which leads to growth retardation. Diet can play a crucial role in processes involved in the OA and LBGI’s onset and evolution. Specifically, there is ample evidence pointing to the negative impacts of caffeine consumption on hyaline cartilage. However, its effects on these tissues have not been reviewed. Accordingly, in this review, we summarize all current knowledge in the PubMed database about caffeine catabolic effects on articular and growth plate cartilage. Specifically, we focus on the correlation between OA and LBGI with caffeine prenatal or direct exposure. Overall, there is ample evidence indicating that caffeine intake negatively affects the physiology of both articular and growth plate cartilage, increasing consumers predisposition to suffer OA and LBGI. As a result, caffeine consumption should be avoided for these pathologies.

show abstract

Mendelian Randomization Studies of Coffee and Caffeine Consumption

Cited by 67 publications

References 74 publications

Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study

Coffee Consumption and Risk of Stroke: A Mendelian Randomization Study

Inter‐Individual Variation in Cancer and Cardiometabolic Health Outcomes in Response to Coffee Consumption: A Critical Review

Caffeine, a Risk Factor for Osteoarthritis and Longitudinal Bone Growth Inhibition

Contact Info

Product

Resources

About