2022
DOI: 10.1073/pnas.2122144119
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Mendel and Darwin

Abstract: Evolution by natural selection is an explicitly genetic theory. Darwin recognized that a working theory of inheritance was central to his theory and spent much of his scientific life seeking one. The seeds of his attempt to fill this gap, his “provisional hypothesis” of pangenesis, appear in his notebooks when he was first formulating his evolutionary ideas. Darwin, in short, desperately needed Mendel. In this paper, we set Mendel’s work in the context of experimental biology and animal/plant breeding of the p… Show more

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Cited by 11 publications
(3 citation statements)
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“…The search for the molecular basis of the gene began at about the same time, with proteins as the odds-on favorite. Protein's fundamental role in living systems was well established, and with over twenty different amino acids they appeared to have the complexity a genetic core would require [59,63,64]. In 1944, Oswald Avery (1877Avery ( -1955 and coworkers definitively identified DNA as the genetic material; however, this did not immediately override the prejudice in favor of proteins [65].…”
Section: The Emergence Of the Modern Synthesismentioning
confidence: 99%
“…The search for the molecular basis of the gene began at about the same time, with proteins as the odds-on favorite. Protein's fundamental role in living systems was well established, and with over twenty different amino acids they appeared to have the complexity a genetic core would require [59,63,64]. In 1944, Oswald Avery (1877Avery ( -1955 and coworkers definitively identified DNA as the genetic material; however, this did not immediately override the prejudice in favor of proteins [65].…”
Section: The Emergence Of the Modern Synthesismentioning
confidence: 99%
“…But he was unable to provide a satisfactory explanation for the origin of these variations and the mechanism underlying their transmission. Darwin and Mendel were contemporaries, but they never met and Mendel's work was ignored by Darwin [2]. About 50 years after Darwin and Mendel died, Darwin's natural selection and Mendelian inheritance, which posits that individuals inherit a combination of alleles from their parents, became two pillars of the modern synthesis.…”
Section: Introductionmentioning
confidence: 99%
“…morphological and functional features, the result of the interaction of the genotype with the environment. Darwin’s natural selection is a key evolutionary mechanism according to which, within the genetic diversity of populations, there is a progressive and cumulative increase of individuals optimized for their living environment [ 1 ]. This variability derives from random genetic mutations, in the sense that they occur by chance, during the generations [ 2 ].…”
Section: Introductionmentioning
confidence: 99%