Men’s willingness to use novel male contraception is linked to gender-equitable attitudes: Results from an exploratory online survey

Nguyen, Brian; Jacobsohn, Tamar L.

doi:10.1016/j.contraception.2023.110001

Cited by 8 publications

(4 citation statements)

References 27 publications

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“…Few studies have examined correlates of men’s willingness to use MBC using multivariable analysis. Similar to our findings, a newly published survey of cisgender men from the United States and Canada found no independent association between MBC willingness and education level, sexual orientation, relationship status, pregnancy history, and parenting status [ 23 ]. However, there was no effect of age (modeled continuously) and estimates were significant for abortion history and some non-White racial/ethnic subgroups.…”

Section: Discussionsupporting

confidence: 89%

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

Martins,

Boraas

2023

Contracept Reprod Med

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Background There is high global demand for new methods of male birth control (MBC). However, contemporary evidence regarding men’s method-specific attitudes and their determinants is sparse. Methods Non-sterilized cisgender men ages 18–45 with recent history of female sex partners were surveyed at a large community event in the Midwestern US. We examined variation in participants’ willingness to use MBC by method (gel, pill, injection, implant, and vas occlusion), potential side effects, and potential barriers. We estimated crude and adjusted prevalence ratios (aPRs) for associations between participant characteristics and willingness to use ≥ 1 MBC method. Results Overall, 72% of participants (n = 187; mean age, 29) were very willing to use ≥ 1 MBC method although support for individual methods ranged widely from 62% (pill) to 24% (vas occlusion). In bivariate analysis of sociodemographic and health characteristics, few demonstrated associations with MBC willingness. In a multivariable model, willingness was independently related to age (30–39 vs. 18–29 years old, aPR = 1.24, 95% CI 1.04–1.48) and having ever been tested for HIV (aPR = 1.27, 95% CI 1.07–1.51). Willingness to tolerate side effects was < 10% for most items. The most commonly endorsed barriers to MBC use were high cost (77%) and side effects (66%). Conclusions Enthusiasm for MBC was high but waned in the context of potential side effects and barriers. Additional research on MBC attitudes in socioeconomically and culturally diverse populations worldwide is sorely needed.

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Section: Discussionsupporting

confidence: 89%

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

Martins,

Boraas

2023

Contracept Reprod Med

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“…Glasier 2010 Nguyen and Jacobsohn 2023 Nickels and Yan 2024 Reynolds-Wright et al 2021 Dorman and Bishai 2012 Nickels and Yan 2024 …”

Section: Ca 2+ Signaling and Male Contraceptionmentioning

confidence: 99%

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

Lee,

Hwang

2024

Animal Cells and Systems

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Ca 2+ is a key secondary messenger that determines sperm motility patterns. Mammalian sperm undergo capacitation, a process to acquire fertilizing ability, in the female reproductive tract. Capacitated sperm change their flagellar waveform to develop hyperactivated motility, which is crucial for successful sperm navigation to the eggs and fertilization. The sperm-specific channel, CATSPER, and an ATPase transporter, PMCA4, serve as major paths for Ca 2+ influx and efflux, respectively, in sperm. The ionic paths coordinate Ca 2+ homeostasis in the sperm, and their loss-of-function impairs sperm motility, to cause male infertility. In this review, we summarize the physiological significance of these two Ca 2+ gates and suggest their potential applications in novel male contraceptives.

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“…Expansion of the method mix to include novel male contraceptive options will contribute to enhanced family planning options and increase the positive outcomes realized by existing available methods ( Dorman et al, 2018 ). In fact, willingness to use a novel male contraceptive is closely related to gender-equitable attitudes ( Nguyen and Jacobsohn, 2023 ), suggesting that a positive feedback loop may occur wherein equitable gender attitudes increase male contraceptive acceptance and use, while male contraceptives themselves may positively influence gender equity and equitable attitudes at the same time. In addition, it stands to reason that contraception can act as a capture point for men in healthcare, wherein men seeking contraceptive services can undergo additional evaluations and improve their preventative care.…”

Section: Male Contraceptive Development Is After All a Women’s Health...mentioning

confidence: 99%

Nonhormonal Male Contraceptive Development—Strategies for Progress

Nickels,

Yan

2023

Pharmacol Rev

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Despite the widely demonstrated public health benefits of contraception, limited contraceptive options are available for men, placing both the contraceptive burden and opportunity solely on women. This review outlines the need for an increased focus on male contraceptive development and highlights several related topics, including the perspectives of women and men on male contraceptives, historical challenges, and reasons behind the persistent delays in male contraceptive development. It also discusses the importance of serendipitous observations in drug discovery and the limitations of depleting sperm or spermatogenic cells as a contraceptive approach. It further provides an overview of ongoing research and development on novel methods, with a goal to offer insights into the multifaceted aspects of nonhormonal male contraceptive development, addressing its implications for the health of men and women. Significance Statement Despite well over half a century of effort in developing male contraceptives, there are no approved male contraceptive drugs on the market. This review aims to present strategies for progress in nonhormonal male contraception based on lessons learned from history, with the hope of expediting development and bringing a male contraceptive drug closer to reality.

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Men’s willingness to use novel male contraception is linked to gender-equitable attitudes: Results from an exploratory online survey

Cited by 8 publications

References 27 publications

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system

Nonhormonal Male Contraceptive Development—Strategies for Progress

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Men’s willingness to use novel male contraception is linked to gender-equitable attitudes: Results from an exploratory online survey

Cited by 8 publications

References 27 publications

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

Willingness to use novel reversible methods of male birth control: a community-based survey of cisgender men in the United States

Ca 2+ homeostasis and male fertility: a target for a new male contraceptive system

Nonhormonal Male Contraceptive Development—Strategies for Progress

Contact Info

Product

Resources

About

Ca ²⁺ homeostasis and male fertility: a target for a new male contraceptive system