Men and women show similar survival rates after breast cancer

Bender, Paulo; Oliveira, Letícia Lima de; Aguiar, Suzana Sales de; Bergmann, Anke; Thuler, Luiz Cláudio Santos

doi:10.1007/s00432-016-2311-4

Cited by 14 publications

(10 citation statements)

References 34 publications

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“…This study included 99 men and 198 women with breast cancer, but the power of sample size was not verified. On the contrast, in an age- and stage-matched cohort male and female breast cancer patients showed no significant difference in 5- and 10-year disease free survival and OS rates 20 . When neglecting imbalance of clinicopathological factors between male and female patients with breast cancer, most of prior comparative studies 21 – 23 consistently found a statistically significant difference in favor of a better prognosis in FBC patients.…”

Section: Discussionmentioning

confidence: 78%

Survival Comparisons Between Early Male and Female Breast Cancer Patients

Wang

Xiong

et al. 2018

Sci Rep

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We aimed to compare the overall survival (OS) and standardized mortality rate (SMR) of the male breast cancer (MBC) with female breast cancer (FBC) after propensity score matching. Based on the Surveillance, Epidemiology, and End Results (SEER), the early breast cancer patients (T1–2N0–2M0) were extracted from 1998–2007. This study included 1,111 and 2,151 patients with early MBC and FBC, respectively, whose clinicopathological characteristics were well balanced. At a mean follow-up time of 97 months, 10-year OS rate was 58.3% in the MBC group and 68.7% in the FBC (log-rank test, P < 0.001; hazard ratio (HR) = 1.45, 95% confidence interval (CI) = 1.29 to 1.64). Adjusted HR for OS between MBC and FBC were revealed from propensity score matched-multivariable Cox proportional hazards models (HR = 1.53, 95% CI = 1.35 to 1.73). Similar adjusted SMRs between MBC and FBC ((SMR = 1.98, 95% CI = 1.83,2.14) for FBC and (SMR = 2.07, 95% CI = 1.88–2.28) for MBC) were observed. The nomogram was constructed for FBC, and predicted probabilities were generally good (C-index = 0.71), whose area under curve is higher than TNM stage classification (0.74 vs 0.62). OS was significantly decreased among early MBC patients compared with FBC, but similar SMRs and its trends by age groups were observed between MBC and FBC except for young patients.

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Section: Discussionmentioning

confidence: 78%

Survival Comparisons Between Early Male and Female Breast Cancer Patients

Wang

Xiong

et al. 2018

Sci Rep

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“…For this reason, it can be justified why, when comparing similar clinical stages between men and women, the 5-year survival rate is lower in the male population ( Giordano et al, 2004 ). Interestingly, a retrospective cohort study in Brazil found no significant difference in prognosis but could found differences in clinical and sociodemographic characteristics ( Bender et al, 2017 ).…”

Section: Discussionmentioning

confidence: 99%

“…Stage at diagnosis in men tends to be more advanced ( Greif et al, 2012 ). Survival rates and prognosis between men and women are similar when comparing patients with the same clinical stage and tumor characteristics (hormone receptors, axillary involvement, tumor size, and histology) ( Bender et al, 2017 ). Survival in men is lower than in women when compared to early-stage disease without lymph node involvement, suggesting that there are differences between gender in the pathogenesis and biology of the neoplasia ( Nahleh et al, 2007 ).…”

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confidence: 99%

Breast Cancer in Men: Clinical and Pathological Analysis of 817 Cases

et al. 2020

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The objective of the current study was to describe breast cancer cases in men according to age, stage, and histology, calculating risks compared to women. It is a retrospective cross-sectional study of all breast cancer cases of the Hospital Cancer Registry of São Paulo state, Brazil, 2000–2015. Variables were age, sex, stage, and histology. Absolute numbers and proportions, Mann–Whitney test and prevalence ratio with 95% confidence interval were used. The study included 93,737 cases, of which 817 were males. The mean age at diagnosis was 60.3 years in men and 56.2 years in women ( p < .001). Stage II was the most common in both sexes (33.9% in men and 36.5% in women). Men had a higher frequency of stage III than women (PR 1.18, 95% CI 1.01–1.37). Stage 0 was significantly more common in women (PR 0.69, 95% CI 0.51–0.94). Ductal carcinoma and its variants were the most common histological types in both sexes (88.7% in men and 89.0% in women). Men had a higher frequency of rarer histological types such as papillary (PR 2.17, 95% CI 1.36–3.44) and sarcomas (PR 4.10, 95% CI 1.86–9.01). In conclusion, in men, breast cancer diagnosis occurred in more advanced ages and stages. Invasive ductal carcinoma was the primary histological type observed, although rarer types were more frequent.

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“…To the editors: With great interests, we read the article by Prof. Bender et al (2017), which concluded that there was no significant difference in prognosis between male and female breast cancer cases.…”

mentioning

confidence: 99%

“…That is to say, the prognosis according to the survival rates should be compared between males, post-menopausal women and pre/peri-menopausal women breast cancer cases. The results and conclusion of the study by Prof. Bender et al (2017) should be carefully interpreted and further assessed.…”

mentioning

confidence: 99%