MEMS: Enabled Drug Delivery Systems

Cobo, Angelica; Sheybani, Roya; Meng, Ellis

doi:10.1002/adhm.201400772

Cited by 55 publications

(47 citation statements)

References 92 publications

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“…the triggered release. [100] The movement mechanisms for mechanical pumps usually include reciprocating, rotatory, or peristaltic, in which the reciprocating motion is the most commonly used in drug delivery systems. [96,97] Micropump Driven Release: Micropumps are an essential component in fluid transport systems to precisely meter and control the motion of liquids.…”

Section: Release Mechanism Selectionmentioning

confidence: 99%

“…[100] The movement mechanisms for mechanical pumps usually include reciprocating, rotatory, or peristaltic, in which the reciprocating motion is the most commonly used in drug delivery systems. [100] These actuators take energy from electricity, heat, liquid pressure, or air pressure, and convert it into some kind of mechanical motion. [99] The actuator converts energy into the movement or deformation in a to-and-fro motion of the membrane to provide force to fluid flow out and into micropumps.…”

Section: Release Mechanism Selectionmentioning

confidence: 99%

“…[100,290] This may permit the personalized or customized medicine to optimize treatment of patients. [100,290] This may permit the personalized or customized medicine to optimize treatment of patients.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

See 2 more Smart Citations

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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Microfabrication technology has enabled the development of novel controlled-release devices that possess an integration of structural, mechanical, and perhaps electronic features, which may address challenges associated with conventional delivery systems. In this feature article, microfabricated devices are described in terms of materials, mechanical design, working principles, and fabrication methods, all of which are key features for production of multifunctional, highly effective drug delivery systems. In addition, the current status and future prospects of different types of microfabricated devices for controlled drug delivery are summarized and analyzed with an emphasis on various routes of administration including ocular, oral, transdermal, and implantable systems. It is likely that microfabrication technology will continue to offer new, alternative solutions to design advanced and sophisticated drug delivery devices that promise to significantly improve medical care.

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Section: Release Mechanism Selectionmentioning

confidence: 99%

Section: Release Mechanism Selectionmentioning

confidence: 99%

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Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Zhang

Jackson

Chiao

2017

Adv Funct Materials

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“…Several ongoing efforts are being carried out in research laboratories to develop remotely activated drug delivery microsystems. Detailed descriptions of these efforts are available in (Sheybani, Schober et al 2013, Cobo, Sheybani et al 2015). …”

Section: Introductionmentioning

confidence: 99%

A wireless implantable micropump for chronic drug infusion against cancer

Cobo

Sheybani

et al. 2016

Sensors and Actuators A: Physical

Self Cite

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We present an implantable micropump with a miniature form factor and completely wireless operation that enables chronic drug administration intended for evaluation and development of cancer therapies in freely moving small research animals such as rodents. The low power electrolysis actuator avoids the need for heavy implantable batteries. The infusion system features a class E inductive powering system that provides on-demand activation of the pump as well as remote adjustment of the delivery regimen without animal handling. Micropump performance was demonstrated using a model anti-cancer application in which daily doses of 30 μL were supplied for several weeks with less than 6% variation in flow rate within a single pump and less than 8% variation across different pumps. Pumping under different back pressure, viscosity, and temperature conditions were investigated; parameters were chosen so as to mimic in vivo conditions. In benchtop tests under simulated in vivo conditions, micropumps provided consistent and reliable performance over a period of 30 days with less than 4% flow rate variation. The demonstrated prototype has potential to provide a practical solution for remote chronic administration of drugs to ambulatory small animals for research as well as drug discovery and development applications.

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“…With the development of MEMS (micro-electro-mechanical systems)9, silicon10, metal11, glass1213 and polymers14 have been proved to be used to fabricate MNs for the delivery of various kinds of pharmaceuticals, such as insulin15, growth hormone16, LMWH17, lidocaine18, vaccines1920 and so on. Compared to silicon and metal MNs, dissolving microneedles (DMNs) have received increasing attention recently because of the following advantages: biocompatibility and biodegradability of the MN matrix materials, considerable drug-loading capacity, avoiding hazard tips after insertion, potentiality in mass production21.…”

mentioning

confidence: 99%

Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery

Wang

Zhu

Liu

et al. 2016

Sci Rep

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Drug loaded dissolving microneedles (DMNs) fabricated with water soluble polymers have received increasing attentions as a safe and efficient transdermal drug delivery system. Usually, to reach a high drug delivery efficiency, an ideal drug distribution is gathering more drugs in the tip or the top part of DMNs. In this work, we introduce an easy and new method to introduce a bubble with controlled size into the body of DMNs. The introduction of bubbles can prevent the drug diffusion into the whole body of the MNs. The heights of the bubbles are well controlled from 75 μm to 400 μm just by changing the mass concentrations of polymer casting solution from 30 wt% to 10 wt%. The drug-loaded bubble MNs show reliable mechanical properties and successful insertion into the skins. For the MNs prepared from 15 wt% PVA solution, bubble MNs achieve over 80% of drug delivery efficiency in 20 seconds, which is only 10% for the traditional solid MNs. Additionally, the bubble microstructures in the MNs are also demonstrated to be consistent and identical regardless the extension of MN arrays. These scalable bubble MNs may be a promising carrier for the transdermal delivery of various pharmaceuticals.

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MEMS: Enabled Drug Delivery Systems

Cited by 55 publications

References 92 publications

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

Microfabricated Drug Delivery Devices: Design, Fabrication, and Applications

A wireless implantable micropump for chronic drug infusion against cancer

Microneedles with Controlled Bubble Sizes and Drug Distributions for Efficient Transdermal Drug Delivery

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