A novel wearable interface is developed to help the disabled fully interact with the computer and operate home appliances. It is practical, natural, and less prone to fatigue, and it can serve as a general-purpose interface. Compared with interfaces based on image processing, infrared, and laser techniques, the current interface is relatively insensitive to the surrounding conditions and is more flexible and robust. Since it is able to perform accurate and stable inertia motion measurement, it can move with the subject and measure the motion directly. Moreover, it allows the disabled to actively interact with the computer since the patient's body motions can be analyzed and converted into computer commands. A survey is conducted to evaluate the proposed system and the results are encouraging.