Memristive plasticity in artificial electrical synapses <i>via</i> geometrically reconfigurable, gramicidin-doped biomembranes

Koner, Subhadeep; Najem, Joseph S.; Hasan, Sakib; Sarles, Stephen A.

doi:10.1039/c9nr07288h

Cited by 17 publications

(26 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Alamethicin is particularly noteworthy as it provides a voltage-dependent conductivity similar to 7R-αHL; however, it requires an input voltage above a threshold for activation as shown in Figure Aa,Bc. Gramicidin channels across DIBs ,, are formed from the dimerization of monomers from each monolayer leaflet; these pores exhibit a selectivity for small monovalent cations , and provide a way of establishing directional communication only between compartments containing the antimicrobial dimer.…”

Section: Functionalized Droplet Interface Bilayer Materialsmentioning

confidence: 99%

Droplet-Based Membranous Soft Materials

Makhoul-Mansour

Freeman

2021

Langmuir

View full text Add to dashboard Cite

Inspired by the structure and functionality of natural cellular tissues, droplet interface bilayer (DIB)-based materials strategically combine model membrane assembly techniques and droplet microfluidics. These structures have shown promising results in applications ranging from biological computing to chemical microrobots. This Feature Article briefly explores recent advances in the areas of construction, manipulation, and functionalization of DIB networks; discusses their unique mechanics; and focuses on the contributions of our lab in the advancement of this platform. We also reflect on some of the limitations facing DIB-based materials and how they might be addressed, highlighting promising applications made possible through the refinement of the material concept.

show abstract

Section: Functionalized Droplet Interface Bilayer Materialsmentioning

confidence: 99%

Droplet-Based Membranous Soft Materials

Makhoul-Mansour

Freeman

2021

Langmuir

View full text Add to dashboard Cite

show abstract

“…An electrical synapse is constructed by two plasma membranes with an ultranarrow cleft (2-4 nm), as shown in Figure 2a, being able to simultaneously provide mechanical and electrical connections and allow fast bidirectional transmission through specific gap junctions. [12,13] The functions of electrical synapse in biology are transiting arousal states and regulating the sensitivity of the cortex to sensation as well as controlling the level of synchronization in neural networks. [12,14] Differently, chemical synapse is more extensive in BioNN and more important for neuro-inspired computing.…”

Section: Electrical Synapse and Chemical Synapsementioning

confidence: 99%

“…[12,13] The functions of electrical synapse in biology are transiting arousal states and regulating the sensitivity of the cortex to sensation as well as controlling the level of synchronization in neural networks. [12,14] Differently, chemical synapse is more extensive in BioNN and more important for neuro-inspired computing. As shown in Figure 2b, the configuration of a typical chemical synapse has presynapse and postsynapse cells, as well as a wider synaptic cleft.…”

Section: Electrical Synapse and Chemical Synapsementioning

confidence: 99%

Phase Change Random Access Memory for Neuro‐Inspired Computing

Wang

Niu

Ren

et al. 2021

Adv Elect Materials

View full text Add to dashboard Cite

Neuro‐inspired computing using emerging memristors plays an increasingly significant role for the realization of artificial intelligence and thus has attracted widespread interest in the era of big data. Thanks to the maturity of technology and the superiority of device performance, phase change random access memory (PCRAM) is a promising candidate for both nonvolatile memories and neuro‐inspired computing. Recently many efforts have been carried out to achieve the biological behavior using PCRAM and to clarify the related working mechanism. In order to further improve device performances, it is helpful and urgent to summarize and discuss the PCRAM solution for neuro‐inspired computing. In this paper, fundamentals, principles, recent progresses, existing challenges, and mainstream solutions are reviewed, and a brief outlook is highlighted and introduced, with the expectation to expound future directions.

show abstract

“…Notably this technique may be accomplished in an encapsulated system and is contact-free. Potential applications include plastic rearrangement events for neuromorphic materials 59 , controlled droplet–droplet exchanges 17 , and the continued development of dynamic functional droplet networks 6 .…”

Section: Introductionmentioning

confidence: 99%

Enhancing membrane-based soft materials with magnetic reconfiguration events

Makhoul-Mansour

El-Beyrouthy

Mao

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Adaptive and bioinspired droplet-based materials are built using the droplet interface bilayer (DIB) technique, assembling networks of lipid membranes through adhered microdroplets. The properties of these lipid membranes are linked to the properties of the droplets forming the interface. Consequently, rearranging the relative positions of the droplets within the network will also alter the properties of the lipid membranes formed between them, modifying the transmembrane exchanges between neighboring compartments. In this work, we achieved this through the use of magnetic fluids or ferrofluids selectively dispersed within the droplet-phase of DIB structures. First, the ferrofluid DIB properties are optimized for reconfiguration using a coupled experimental-computational approach, exploring the ideal parameters for droplet manipulation through magnetic fields. Next, these findings are applied towards larger, magnetically-heterogeneous collections of DIBs to investigate magnetically-driven reconfiguration events. Activating electromagnets bordering the DIB networks generates rearrangement events by separating and reforming the interfacial membranes bordering the dispersed magnetic compartments. These findings enable the production of dynamic droplet networks capable of modifying their underlying membranous architecture through magnetic forces.

show abstract

Memristive plasticity in artificial electrical synapses via geometrically reconfigurable, gramicidin-doped biomembranes

Abstract: An artificial electrical synapse that mimics the structure, transport properties, and plasticity of biological electrical synapses exhibits voltage-controlled memristance by exploiting reconfigurable membrane geometry.

Cited by 17 publications

References 67 publications

Droplet-Based Membranous Soft Materials

Droplet-Based Membranous Soft Materials

Phase Change Random Access Memory for Neuro‐Inspired Computing

Enhancing membrane-based soft materials with magnetic reconfiguration events

Contact Info

Product

Resources

About