Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis of Lichen Planus and Lichenoid Mucositis

Devi, M

doi:10.7860/jcdr/2017/26866.9930

Cited by 8 publications

(10 citation statements)

References 13 publications

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“…They are located deep in the lamina propria rather than the subepithelial zone, so they probably do not affect directly the disease process, but they are connected with the autoimmune process. Similarly, CD38 expression in B cells was found in 55% of lesions [11] and memory T cells in 53.3% of lesions [12]. Research also revealed an increased level of Th9 cells.…”

Section: Cellular Markersmentioning

confidence: 82%

“…Są one obecne głęboko w blaszce właściwej, a nie w strefie podnabłonkowej, a zatem prawdopodobnie nie wpływają bezpośrednio na proces chorobowy, natomiast wykazują zależność z procesem autoimmunologicznym. Ekspresję CD38 w limfocytach B stwierdzono w 55% zmian [11], a limfocyty T pamięci w 53,3% zmian [12]. W badaniach wykazano również podwyższone stężenie limfocytów Th9.…”

Section: Cellular Markersunclassified

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Immunological abnormalities in lichen planus

Ostrowska¹,

Susło²

2022

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Lichen planus is a chronic disease associated with the occurrence of characteristic papular pruritic lesions. The most significant immunological markers of lichen planus are cytokines. Numerous publications showed changes in the serum level of tumor necrosis factor, interferon g, interleukins 2, 4, 6, 8, 10, 17 and 22. Early lichen planus is associated with a high number of macrophages, T cells, and dendritic cells, while advanced lichen planus with a high number of Treg cells. There is no single specific marker for lichen planus, but certain cytokine levels can be used as a prognostic factor for disease progression and as an indicator of treatment response. Analysis of the immune markers can help to define the disease stage and lichen planus subtype, but histopathology still remains a standard in lichen planus diagnosis.

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Section: Cellular Markersmentioning

confidence: 82%

Section: Cellular Markersunclassified

Immunological abnormalities in lichen planus

Ostrowska¹,

Susło²

2022

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“…Most naïve human T cells express a form of CD45RA, whereas memory T cells express a different isoform called CD45RO. Memory T cells have the ability to survive for long periods of time and are responsible for the rapid responses on subsequent exposure to antigen CD45RO [ 43 ]. In our previous study we observed that in patients with COVID-19 infection, lymphocytes CD8+ manifested effector profile, meanwhile lymphocytes CD4+ directed to memory profile [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Usefulness of the New Hematological Parameter: Reactive Lymphocytes RE-LYMP with Flow Cytometry Markers of Inflammation in COVID-19

Rutkowska

Kwiecień

Kulik

et al. 2021

Cells

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Identification of patients with activation of the immune system which indicates the presence of infection is essential, especially in the times of the global coronavirus 2019 (COVID-19) pandemic. The aim of the present study was to evaluate the reactive lymphocytes (RE-LYMP) parameter in COVID-19 and to correlate it with activation lymphocytes markers by flow cytometry. The study group consisted of 40 patients: with COVID-19 infection (n = 20) and with others virus infections without COVID-19 (COVID-19(−) virus (n = 20)) and 20 healthy donors (HC). Blood count and flow cytometry were performed. The COVID-19(+) group had significantly lower RE-LYMP parameter than the COVID-19(−) virus group (5.45 vs. 11.05, p < 0.05). We observed higher proportion of plasmablasts in the COVID-19(+) and COVID-19(−) virus groups than HC (8.8 vs. 11.1 vs. 2.7, p < 0.05). In the COVID-19(+) there was a lower proportion of CD4+ CD38+ cells than in the other groups (significant differences between COVID-19(+) and COVID-19(−) virus groups). RE-LYMP correlated with activated T lymphocytes CD38+ and HLA-DR+ in the COVID-19(−) virus group, however in the COVID-19(+) group correlations with T lymphocytes CD25+ and CD45RO+ were observed. In summary the analysis of the RE-LYMP together with flow cytometric activation markers can be helpful in identifying and distinguishing patients with COVID-19(+) from other viruses and HC.

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“…Dendritic cells are the most potent antigen presenting cells for lymphocytes 51,52 . These cells present the antigen to memory T cells, the predominant phenotype in OLP 53 . It is known that CXCR4 is highly-expressed in resting T cells, including naïve and memory T cells, and is downregulated during T cell activation 54 .…”

Section: Discussionmentioning

confidence: 99%

Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets

Rivera

Crisóstomo

Peña

et al. 2020

Sci Rep

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Today, we face difficulty in generating new hypotheses and understanding oral lichen planus due to the large amount of biomedical information available. In this research, we have used an integrated bioinformatics approach assimilating information from data mining, gene ontologies, protein-protein interaction and network analysis to predict candidate genes related to oral lichen planus. A detailed pathway analysis led us to propose two promising therapeutic targets: the stromal cell derived factor 1 (CXCL12) and the C-X-C type 4 chemokine receptor (CXCR4). We further validated our predictions and found that CXCR4 was upregulated in all oral lichen planus tissue samples. Our bioinformatics data cumulatively support the pathological role of chemokines and chemokine receptors in oral lichen planus. From a clinical perspective, we suggest a drug (plerixafor) and two therapeutic targets for future research. Oral lichen planus (OLP) is a chronic immunologically mediated disease 1. Histopathological features of OLP include hyperkeratosis, acanthosis, degeneration by liquefaction of the basal keratinocyte layer, and prominent lymphocyte infiltration at the connective tissue-epithelium interface 2. OLP is not a homogeneous clinical entity, but a complex disease. A recent review proposes a new classification of this disease, taking into consideration a set of lesions with similar characteristics, including oral lichenoid contact lesions, oral lichenoid drug reactions, and lichen planus pemphigoides, among others 3 .The clinical findings vary from white reticular plaques to erythema, erosions, ulceration, and hyperkeratotic plaques in the oral mucosa 4. Although reticular lesions are often asymptomatic, burning or pain often accompanies erosive/ulcerative manifestations of OLP. The severity of pain may vary from mild to severe and may even interfere with patients' speech, feeding, and swallowing 4. According to the WHO, this disease has a potential for cancerization 5. This potential is presented in about 1% of patients 6. Despite the efforts in biomedical research, the etiology of OLP is unknown, and its molecular basis is still unclear. This may explain why the treatment is palliative. For these reasons, exploration of the mechanisms that govern the disease's pathophysiological process is needed. A disease is rarely the result of an abnormality in a single gene, but it reflects disturbances in the complex intracellular and intercellular network that links tissue and organ systems 7. Today, we face difficulty in generating new hypotheses and understanding OLP due to the large amount of biomedical information available. Encapsulating that information in an understandable way is one of the current challenges of network-based approaches to the study of human diseases 8. The heterogeneity of pathologies, the difficulty of finding a gene or protein in a certain localization, and the cost involved in experimental studies have led to the development of several in silico approaches for the identification of genes and proteins assoc...

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Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis of Lichen Planus and Lichenoid Mucositis

Cited by 8 publications

References 13 publications

Immunological abnormalities in lichen planus

Immunological abnormalities in lichen planus

Usefulness of the New Hematological Parameter: Reactive Lymphocytes RE-LYMP with Flow Cytometry Markers of Inflammation in COVID-19

Oral lichen planus interactome reveals CXCR4 and CXCL12 as candidate therapeutic targets

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