Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model

Ostrovskaya, R. U.; Romanova, G. A.; Барсков, И. В.; Shanina, E.; Gudasheva, T. A.; Victorov, Ilya V.; Воронина, Т. А.; Середенин, С. Б.

doi:10.1097/00008877-199909000-00013

Cited by 35 publications

(20 citation statements)

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“…Neuroprotective Effect of GK-2, Noopept[8], and Semax[5] in Photochemical Stroke Noopept, 0.5 mg/kg intraperitoneally (m=9) Semax, 0.25 mg/kg intranasally (m=7) Note. m: number of days of drug injection.…”

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confidence: 99%

Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

et al. 2011

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The neuroprotective and antiamnestic effects of GK-2 dipeptide (nerve growth factor mimetic) were studied on rats with photoinduced bilateral focal ischemia of the prefrontal cortex. Intraperitoneal injection of GK-2 in a dose of 1 mg/kg on days 1, 2, 4, and 6 postoperation led to a 62% reduction of cortical infarction volume on day 9 and completely preserved conditioned passive avoidance response trained before stroke.

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confidence: 99%

Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

et al. 2011

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“…(Chen et al 2004;De Ryck et al 1996;De Ryck et al 1989;De Ryck et al 2000;Eichenbaum et al 2002;Futrell et al 1988;Lozano et al 2007;Ostrovskaya et al 1999) Autologous clot model Clot-related protection mechanisms. (Beech et al 2001;Busch et al 1997;Harada et al 2005;Kano et al 2003;Kano et al 2005;Kilic et al 1998;Krueger and Busch 2002;Orset et al 2007;Romanos et al 2007;Tejima et al 2001;Toomey et al 2002;Vosko et al 2003) Endothelin-1 model Transient to semi-permanent focal cerebral ischemia that need outcome measurements of both histology and neurofunctions (Biernaskie et al 2001;Horie et al 2008;Nikolova et al 2009;Windle et al 2006) Tamura model Permanent focal cerebral ischemia.…”

Section: Stroke Model Preferred Application Referencementioning

confidence: 99%

“…The light used for inducing this reaction can be laser or filtered non-laser light, and can be shone onto a section of artery wall or any location of the skull. Therefore, this model is useful for neuroprotection that is associated with a particular brain cortex region and involves free radical scavenging as a protective mechanism (Chen et al 2004;De Ryck et al 1996;De Ryck et al 1989;De Ryck et al 2000;Eichenbaum et al 2002;Futrell et al 1988;Lozano et al 2007;Ostrovskaya et al 1999).…”

Section: About the Photochemical Modelmentioning

confidence: 99%

Rodent Stroke Model Guidelines for Pre-clinical Stroke Trials (1st edition).

Liu¹,

Zhen²,

Meloni³

et al. 2009

J Exp Stroke Transl Med

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Translational stroke research is a challenging task that needs long term team work of the stroke research community. Highly reproducible stroke models with excellent outcome consistence are essential for obtaining useful data from preclinical stroke trials as well as for improving inter-lab comparability. However, our review of literature shows that the infarct variation coefficient of commonly performed stroke models ranges from 5% to 200%. An overall improvement of the commonly used stroke models will further improve the quality for experimental stroke research as well as inter-lab comparability. Many factors play a significant role in causing outcome variation; however, they have not yet been adequately addressed in the Stroke Therapy Academic Industry Roundtable (STAIR) recommendations and the Good Laboratory Practice (GLP). These critical factors include selection of anesthetics, maintenance of animal physiological environment, stroke outcome observation, and model specific factors that affect success rate and variation. The authors have reviewed these major factors that have been reported to influence stroke model outcome, herewith, provide the first edition of stroke model guidelines so to initiate active discussion on this topic. We hope to reach a general agreement among stroke researchers in the near future with its successive updated versions.

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“…Photothrombosis of the prefrontal cortex in rats is accompanied by local ischemic injury, which extends over the width of the cortex [6,10]. Experimental photothrombosis results in local ischemic injury of the desired location, constant volume, and high reproducibility.…”

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Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex

2008

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We studied the neuroprotective effect of a new selective anxiolytic afobazole on rats with bilateral focal ischemic stroke in the prefrontal cortex caused by photothrombosis. Intraperitoneal injection of 5 mg/kg afobazole 1 h after surgery and over the next 8 days (daily treatment) produced a neuroprotective effect. Afobazole was far superior to the reference cerebroprotective drug cavinton (4 mg/kg) by neuroprotective activity.

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Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model

Cited by 35 publications

References 0 publications

Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

Neuroprotective and Antiamnestic Effect of Nerve Growth Factor Dipeptide Mimetic GK-2 in Experimental Ischemic Infarction of Brain Cortex

Rodent Stroke Model Guidelines for Pre-clinical Stroke Trials (1st edition).

Neuroprotective effect of afobazole on rats with bilateral local photothrombosis of vessels in the prefrontal cortex

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