Memory-related white matter tract integrity in amyotrophic lateral sclerosis: an advanced neuroimaging and neuropsychological study

Christidi, Foteini; Karavasilis, Efstratios; Zalonis, Ioannis; Ferentinos, Panagiotis; Giavri, Zoi; Wilde, Elisabeth A.; Xirou, Sophia; Rentzos, Michael; Zouvelou, Vasiliki; Velonakis, Georgios; Toulas, Panagiotis; Efstathopoulos, Efstathios; Poulou, Loukia S.; Argyropoulos, G; Athanasakos, Athanasios; Levin, Harvey S.; Karandreas, Nikolaos; Kelekis, Nikolaos; Evdokimidis, Ioannis

doi:10.1016/j.neurobiolaging.2016.09.014

Cited by 31 publications

(30 citation statements)

References 77 publications

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“…Human neuroimaging studies are now also pointing to the importance of the uncinate fascicle, the white matter pathway connecting the inferotemporal cortex to the inferior convexity and orbital surface of the prefrontal cortex (Ungerleider et al ., ) for learning visual associations (Thomas et al ., ). Furthermore, in patients with mild cognitive impairment, a precursor to Alzheimer's disease, and in amyotrophic lateral sclerosis patients with memory deficits, changes in the integrity of the uncinate fascicle have been correlated with the extent of the memory decline (Christidi et al ., ; Liu et al ., ; Wang et al ., ). Finally, recent neuroimaging evidence from macaque monkeys has also demonstrated areas activated within a temporal–prefrontal cortex network during learning and long‐term memories for object–reward associations (Ghazizadeh et al ., ).…”

Section: Discussionmentioning

confidence: 99%

Macaque parvocellular mediodorsal thalamus: dissociable contributions to learning and adaptive decision‐making

Chakraborty

Ouhaz

Mason

et al. 2018

Eur J of Neuroscience

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Distributed brain networks govern adaptive decision-making, new learning and rapid updating of information. However, the functional contribution of the rhesus macaque monkey parvocellular nucleus of the mediodorsal thalamus (MDpc) in these key higher cognitive processes remains unknown. This study investigated the impact of MDpc damage in cognition. Preoperatively, animals were trained on an object-in-place scene discrimination task that assesses rapid learning of novel information within each session. Bilateral neurotoxic (NMDA and ibotenic acid) MDpc lesions did not impair new learning unless the monkey had also sustained damage to the magnocellular division of the MD (MDmc). Contralateral unilateral MDpc and MDmc damage also impaired new learning, while selective unilateral MDmc damage produced new learning deficits that eventually resolved with repeated testing. In contrast, during food reward (satiety) devaluation, monkeys with either bilateral MDpc damage or combined MDpc and MDmc damage showed attenuated food reward preferences compared to unoperated control monkeys; the selective unilateral MDmc damage left performance intact. Our preliminary results demonstrate selective dissociable roles for the two adjacent nuclei of the primate MD, namely, MDpc, as part of a frontal cortical network, and the MDmc, as part of a frontal-temporal cortical network, in learning, memory and the cognitive control of behavioural choices after changes in reward value. Moreover, the functional cognitive deficits produced after differing MD damage show that the different subdivisions of the MD thalamus support distributed neural networks to rapidly and fluidly incorporate task-relevant information, in order to optimise the animals' ability to receive rewards.

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Section: Discussionmentioning

confidence: 99%

Macaque parvocellular mediodorsal thalamus: dissociable contributions to learning and adaptive decision‐making

Chakraborty

Ouhaz

Mason

et al. 2018

Eur J of Neuroscience

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“…Dysfunction of the insula has been implicated as a contributing factor to verbal‐fluency deficits, which typify the overall executive dysfunction in ALS . Systematic investigations of the sub‐cortical structures have also revealed the involvement of the thalamus and the hippocampus, including its relation to memory‐deficits, in ALS . Thus, the extra‐motor changes in short‐survivors potentially reflect the extra‐motor phenotype of the disease.…”

Section: Discussionmentioning

confidence: 99%

Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis

Ishaque

Mah

Seres

et al. 2018

Ann Clin Transl Neurol

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ObjectiveTo evaluate cerebral degenerative changes in ALS and their correlates with survival using 3D texture analysis.MethodsA total of 157 participants were included in this analysis from four neuroimaging studies. Voxel‐wise texture analysis on T1‐weighted brain magnetic resonance images (MRIs) was conducted between patients and controls. Patients were divided into long‐ and short‐survivors using the median survival of the cohort. Neuroanatomical differences between the two survival groups were also investigated.ResultsWhole‐brain analysis revealed significant changes in image texture (FDR P < 0.05) bilaterally in the motor cortex, corticospinal tract (CST), insula, basal ganglia, hippocampus, and frontal regions including subcortical white matter. The texture of the CST correlated (P < 0.05) with finger‐ and foot‐tapping rate, measures of upper motor neuron function. Patients with a survival below the media of 19.5 months demonstrated texture change (FDR P < 0.05) in the motor cortex, CST, basal ganglia, and the hippocampus, a distribution which corresponds to stage 4 of the distribution TDP‐43 pathology in ALS. Patients with longer survival exhibited texture changes restricted to motor regions, including the motor cortex and the CST.InterpretationWidespread gray and white matter pathology is evident in ALS, as revealed by texture analysis of conventional T1‐weighted MRI. Length of survival in patients with ALS is associated with the spatial extent of cerebral degeneration.

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“…81,98,99 However, recent studies report authentic episodic memory deficits and implicate MTL structures, showing that memory impairment in non-demented ALS patients is not exclusively a disturbance of the executive functioning. 52,82,83,88,[100][101][102][103] Semantic memory Semantic memory is the knowledge of everyday objects and events and its loss is attributed to the deterioration of the ATL. 61,104 In particular, the temporal poles, the most anterior part of the ATL, are proposed to have a general function to form the basis of semantic memory and is also linked to face recognition, processing of auditory, olfactory and visual stimuli and ToM processing.…”

Section: Clinical/neuropsychological Findingsmentioning

confidence: 99%

How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

Bueno

Bertoux

Souza

et al. 2017

Ann Clin Neurophysiol

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Detection of underling proteinopathies is becoming increasingly important across neurodegenerative conditions due to upcoming disease intervention trials. In this review, we explored how temporal lobe changes in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) can potentially predict underlying TDP-43 pathology subtypes in FTD. To date, emphasis has been given to frontal lobe changes in the study of the cognitive and behavioural impairments in both syndromes but an increasing number of pathological, imaging and neuropsychological studies suggest how temporal lobe changes could critically affect the cognition and behaviour of these conditions. In this current article, we reviewed pathological, imaging as well as clinical/neuropsychological findings of temporal involvement in the ALS-FTD continuum, how they relate to temporal lobe changes and the underlying TDP-43 pathology in FTD. Findings across studies show that TDP-43 pathology occurs and coincides in many structures in ALS and FTD, but especially in the temporal lobes. In particular, anterior and medial temporal lobes atrophy is consistently found in ALS and FTD. In addition, memory and language impairment as well as emotional and Theory of Mind processing deficits that are characteristics of the two diseases are highly correlated to temporal lobe dysfunction. We conclude by showing that temporal lobe changes due to TDP-43 type B might be particular predictive of TDP-43 type B pathology in behavioural variant FTD, which clearly needs to be investigated further in the future.

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Memory-related white matter tract integrity in amyotrophic lateral sclerosis: an advanced neuroimaging and neuropsychological study

Cited by 31 publications

References 77 publications

Macaque parvocellular mediodorsal thalamus: dissociable contributions to learning and adaptive decision‐making

Macaque parvocellular mediodorsal thalamus: dissociable contributions to learning and adaptive decision‐making

Evaluating the cerebral correlates of survival in amyotrophic lateral sclerosis

How predictive are temporal lobe changes of underlying TDP-43 pathology in the ALS-FTD continuum?

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