Memory-related gene expression profile of the male rat hippocampus induced by teeth extraction and occlusal support recovery

Iida, Sosuke; Hara, Tetsuya; Araki, Daisuke; Ishimine-Kuroda, Chisa; Kurozumi, Akimasa; Sakamoto, Shuji; Miyazaki, Takafumi; Minagi, Shogo

doi:10.1016/j.archoralbio.2013.10.003

Cited by 16 publications

(15 citation statements)

References 40 publications

(41 reference statements)

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“…The expression of S100a9 may be affected by occlusal support. These findings demonstrate that Trh, Tnxa, Nnat and S100a9 genes may affect memory in rats [14].…”

Section: The Possible Molecular Pathogenesis Of the Hippocampal Altersupporting

confidence: 54%

“…Chronic stress significantly decreased long-term potentiation (LTP) in rat hippocampal CA1 neurons [15,17,22,54]. It is suggested that thytotropin-releasing hormone (Trh), tenascin XA (Tnxa), neuronatin (Nnat), and S100a9 genes may affect memory in rats [14]. Trh is a neuropeptide originally discovered for its function as a hypothalamic factor controlling the synthesis and release of thyrotropin from the pituitary.…”

Section: The Possible Molecular Pathogenesis Of the Hippocampal Altermentioning

confidence: 99%

“…Prolonged exposure to stress has been shown to promote dendritic atrophy, diminish cell proliferation, and impair synaptic plasticity of the hippocampal neurons in mice and rats [6][7][8][9][10][11][12][13]. Recent studies showed that chronic stress produced a downregulation of memoryrelated signaling pathways and genes in the hippocampal neurons, including brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (TrkB) [14][15][16][17][18][19]. These findings indicate that the toothless condition in aged mice causes serious behavioral and morphologic changes in the hippocampus via chronic stress.…”

Section: Introductionmentioning

confidence: 99%

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Relationship between the Early Toothless Condition and Hippocampal Functional Morphology

Iinuma

Kondo²,

Kurahashi³

et al. 2013

Anat Physiol

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Hippocampus is important for learning and memory. This article reviews the recent progress of the relationship between the toothless condition and the hippocampal functional morphology. Tooth loss early in life was generated by extracting the upper molars shortly after tooth eruption in mice or rat. Morphological and physiological studies showed that early toothlessness, acting as a chronic stress, induced constantly elevated levels of corticosterone, leading to morphological and molecular alterations in hippocampus, accompanied by deficits in spatial learning and memory. The early toothlessness may be a risk factor of cognitive impairment. Adequate dental treatments such as denture or dental implants for defective part of teeth are considered to be important for maintaining the hippocampal functions. The possible mechanism of the hippocampal alterations induced by early toothless condition is also discussed.

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“…The expression of S100a9 may be affected by occlusal support. These findings demonstrate that Trh, Tnxa, Nnat and S100a9 genes may affect memory in rats [14].…”

Section: The Possible Molecular Pathogenesis Of the Hippocampal Altersupporting

confidence: 54%

Section: The Possible Molecular Pathogenesis Of the Hippocampal Altermentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Relationship between the Early Toothless Condition and Hippocampal Functional Morphology

Iinuma

Kondo²,

Kurahashi³

et al. 2013

Anat Physiol

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“…Recent studies showed that impairment of masticatory function downregulated memory-related signaling pathways and genes in the hippocampal neurons, including brain-derived neurotrophic factor (BDNF) and its receptor, tropomyosin-related kinase B (trkB) 54, 55. BDNF is a family of nerve growth factors which bind to trkB.…”

Section: Hippocampal Functional Morphological Changes Caused the Mastmentioning

confidence: 99%

Chewing Maintains Hippocampus-Dependent Cognitive Function

Chen¹,

Iinuma²,

Onozuka³

et al. 2015

Int. J. Med. Sci.

100

105

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Mastication (chewing) is important not only for food intake, but also for preserving and promoting the general health. Recent studies have showed that mastication helps to maintain cognitive functions in the hippocampus, a central nervous system region vital for spatial memory and learning. The purpose of this paper is to review the recent progress of the association between mastication and the hippocampus-dependent cognitive function. There are multiple neural circuits connecting the masticatory organs and the hippocampus. Both animal and human studies indicated that cognitive functioning is influenced by mastication. Masticatory dysfunction is associated with the hippocampal morphological impairments and the hippocampus-dependent spatial memory deficits, especially in elderly. Mastication is an effective behavior for maintaining the hippocampus-dependent cognitive performance, which deteriorates with aging. Therefore, chewing may represent a useful approach in preserving and promoting the hippocampus-dependent cognitive function in older people. We also discussed several possible mechanisms involved in the interaction between mastication and the hippocampal neurogenesis and the future directions for this unique fascinating research.

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“…Memory-related genes that are affected by tooth loss and the recovery of occlusal support were detected [9] in the results of DNA microarray analysis of gene expression in the hippocampus during behavioral memory. As this study was comprehensive, specific expression sites of these genes could not be clarified.…”

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confidence: 99%