Memory Rehabilitation Strategies in Nonsurgical Temporal Lobe Epilepsy

Felice, Alessandra Del; Alderighi, Marzia; Martinato, Matteo; Grisafi, Davide; Bosco, Anna; Thompson, Pamela J.; Sander, Josemir W.; Masiero, Stefano

doi:10.1097/phm.0000000000000714

Cited by 20 publications

(5 citation statements)

References 39 publications

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“…Although there has been increasing emphasis on screening and early identification of comorbidities, there is a clear need for systematic intervention trials to improve practice and patient outcomes. Appearing are reports of interventions designed to improve memory and cognition (Adams et al, 2017; Caller et al, 2016; Del Felice et al, 2017; Farina, Raglio, & Giovagnoli, 2015; Jackson, Makin, & Baker, 2015), mood disorders (Gandy, Sharpe, & Perry, 2013), and epilepsy self-management (Jobst & MEW network, 2017; Shegog et al, 2013; Wagner et al, 2017). Both pharmacologic and behavioral interventions will be critical to improving patient life outcomes in patients with chronic epilepsy (Del Felice et al, 2017) and those who have undergone epilepsy surgery (Mazur-Mosiewicz et al, 2015).…”

Section: Where Will (Should) Neuropsychology Head During the Next Decmentioning

confidence: 99%

Paradigm Shifts in the Neuropsychology of Epilepsy

Hermann

Loring

Wilson

2017

J Int Neuropsychol Soc

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This article reviews the major paradigm shifts that have occurred in the area of the application of clinical and experimental neuropsychology to epilepsy and epilepsy surgery since the founding of the International Neuropsychological Society. The five paradigm shifts discussed include: 1) The neurobiology of cognitive disorders in epilepsy – expanding the landscape of syndrome-specific neuropsychological impairment; 2) pathways to comorbidities: bidirectional relationships and their clinical implications; 3) discovering quality of life: The concept, its quantification and applicability; 4) outcomes of epilepsy surgery: challenging conventional wisdom; and 5) Iatrogenic effects of treatment: cognitive and behavioral effects of antiepilepsy drugs. For each area we characterize the status of knowledge, the key developments that have occurred, and how they have altered our understanding of the epilepsies and their management. We conclude with a brief overview of where we believe the field will be headed in the next decade which includes changes in assessment paradigms, moving from characterization of comorbidities to interventions; increasing development of new measures, terminology and classification; increasing interest in neurodegenerative proteins; transitioning from clinical seizure features to modifiable risk factors; and neurobehavioral phenotypes. Overall, enormous progress has been made over the lifespan of the INS with promise of ongoing improvements in understanding of the cognitive and behavioral complications of the epilepsies and their treatment. (JINS, 2017,23, 791–805)

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Section: Where Will (Should) Neuropsychology Head During the Next Decmentioning

confidence: 99%

Paradigm Shifts in the Neuropsychology of Epilepsy

Hermann

Loring

Wilson

2017

J Int Neuropsychol Soc

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“…This protocol describes a planned randomized waitlist-control trial of CoRE in epilepsy. The study was designed to address major research gaps identified through recent systematic literature reviews in this field, as discussed below ( 5 , 6 , 23 ).…”

Section: Discussionmentioning

confidence: 99%

Rehabilitation of cognition and psychosocial well-being – a better life with epilepsy (ReCaP-ABLE): a protocol for a randomized waitlist-controlled trial

Puteikis,

Jakonienė,

Jasionis

et al. 2023

Front. Neurol.

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Despite advances in the understanding of cognitive dysfunction among people with epilepsy (PWE), evidence for cognitive rehabilitation in epilepsy (CoRE) remains scarce. We present the protocol of a randomized waitlist-controlled trial (ClinicalTrials.gov ID NCT05934786) of a psychological-behavioral intervention aiming to ameliorate quality of life as well as cognitive functioning in a mixed PWE sample. The study is set at Vilnius University Hospital Santaros Klinikos and will offer adult PWE six individual and two group sessions led by a certified psychologist and directed toward improving memory, attention, self-regulation, mood and quality of life. The trial is expected to address major gaps in the literature by providing novel evidence on the effectiveness of CoRE in patients with genetic generalized epilepsies, the importance of epilepsy-specific factors for the response to CoRE, the impact of CoRE on long-term memory as well as its maintenance effects.

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“…Even wakeful resting after having learnt new data has been demonstrated to improve long-term recollection [107,108]. Del Felice et al reviewed existing memory rehabilitation studies in patients with TLE and proposed that cognitive strategies, external mental aids, computerized training and non-invasive brain stimulation should be further explored to provide behavioral and mental techniques for reducing the burden of forgetfulness [109].…”

Section: Memory Rehabilitationmentioning

confidence: 99%

A Review of Accelerated Long-Term Forgetting in Epilepsy

et al. 2020

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Accelerated long-term forgetting (ALF) is a memory disorder that manifests by a distinct pattern of normal memory for up to an hour after learning, but an increased rate of forgetting during the subsequent hours and days. The topic of ALF has gained much attention in group studies with epilepsy patients and the phenomenon has been shown to have contradictory associations with seizures, epileptiform activity, imaging data, sleep, and antiepileptic medication. The aim of this review was to explore how clinical and imaging data could help determine the topographic and physiological substrate of ALF, and what is the possible use of this information in the clinical setting. We have reviewed 51 group studies in English to provide a synthesis of the existing findings concerning ALF in epilepsy. Analysis of recently reported data among patients with temporal lobe epilepsy, transient epileptic amnesia, and generalized and extratemporal epilepsies provided further indication that ALF is likely a disorder of late memory consolidation. The spatial substrate of ALF might be located along the parts of the hippocampal–neocortical network and novel studies reveal the increasingly possible importance of damage in extrahippocampal sites. Further research is needed to explore the mechanisms of cellular impairment in ALF and to develop effective methods of care for patients with the disorder.

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Memory Rehabilitation Strategies in Nonsurgical Temporal Lobe Epilepsy

Cited by 20 publications

References 39 publications

Paradigm Shifts in the Neuropsychology of Epilepsy

Paradigm Shifts in the Neuropsychology of Epilepsy

Rehabilitation of cognition and psychosocial well-being – a better life with epilepsy (ReCaP-ABLE): a protocol for a randomized waitlist-controlled trial

A Review of Accelerated Long-Term Forgetting in Epilepsy

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