Memory Reconsolidation

Haubrich, Josué; Nader, Karim

doi:10.1007/7854_2016_463

Cited by 68 publications

(38 citation statements)

References 185 publications

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“…Various forms of cognitive behavioral therapies involve re-exposure to reminders of the trauma. Some attempt to interfere with the reconsolidation of the traumatic memory (Brunet et al 2018; Haubrich and Nader 2018), others focus on the trauma with the goal of teaching better coping skills (Resick and Schnicke 1992; Kozel et al 2018). Exposure to reminders of the trauma can result in extinction of conditioned fear, which depends upon the suppression of old learned associations by the formation of new associations (Bouton 2004; Sotres-Bayon et al 2006; Quirk and Mueller 2008).…”

Section: Introductionmentioning

confidence: 99%

Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies

2018

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Section: Introductionmentioning

confidence: 99%

Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies

2018

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“…In light of this, it has been suggested by researchers that ''reconsolidation''-based therapy may be more clinically effective and less stressful. Utilizing behavioral strategies and/or pharmacological methods to interfere with this process has been shown to successfully impair the reconsolidation of cue memories in animals (Lewis, 1979;Nader, 2003;Lee et al, 2005Lee et al, , 2006Lee et al, , 2017Tronson and Taylor, 2007;Sanchez et al, 2010;Sorg, 2012;Xue et al, 2012;Sartor and Aston-Jones, 2014;Taylor and Torregrossa, 2015;Torregrossa and Taylor, 2016;Dunbar and Taylor, 2017a;Monsey et al, 2017;Haubrich and Nader, 2018).…”

Section: Introductionmentioning

confidence: 99%

Regulation of Garcinol on Histone Acetylation in the Amygdala and on the Reconsolidation of a Cocaine-Associated Memory

Monsey¹,

Ruiz²,

Taylor³

2020

Front. Behav. Neurosci.

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Exposure to drug-related cues often disrupts abstinence from cocaine use by triggering memories of drug effects, leading to craving and possible relapse. One prospective method of treatment is weakening cocaine-associated memories via impairment of memory reconsolidation. Previous experiments have shown that systemic injection of the amnestic agent garcinol impairs the reconsolidation of cocaine-cue memories in a temporally constrained, cue-specific, and persistent manner. Here, we investigated garcinol's effect on cocaine-cue memory reconsolidation when administered to the lateral nucleus of the amygdala (LA), as well as its epigenetic activity following systemic garcinol administration and also when given in conjunction with trichostatin A (TSA), a histone deacetylase (HDAC) inhibitor. Rats received 12 days of cocaine self-administration training during which time an active lever press resulted in an i.v. cocaine infusion that was concurrently paired with the presentation of a light/tone cue. After 8 days of lever extinction, rats received a memory reactivation session followed by a cue-induced reinstatement test. Intra-LA garcinol following memory reactivation significantly impaired reconsolidation only if the memory was reactivated. Additional studies revealed a significant reduction in histone H3 K27 acetylation and reduced expression of the immediate-early genes Arc and Egr-1 in the LA. When administered alone, TSA enhanced the reinstatement of a cocaine-cue memory, an effect that was prevented when garcinol was concurrently administered. These data indicate the LA is a key structure responsive to garcinol, suggest that one of garcinol's mechanisms of action is through the reduction of memory-related gene expression in the LA, implicate changes in histone acetylation in memory reconsolidation, and support garcinol as a potential therapeutic tool for sustaining abstinence.

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“…destabilized) where it can be modified. Importantly, the memory must undergo a re-stabilization process called reconsolidation in order to persist 1 . This process of destabilization-reconsolidation allows memories to adaptively change.…”

Section: Introductionmentioning

confidence: 99%

Noradrenergic projections from the locus coeruleus to the amygdala constrain auditory fear memory reconsolidation

Haubrich

Bernabo

Nader

2020

Preprint

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Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we extend the understanding of the mechanisms implicated in reconsolidation-resistant memories by investigating the hypothesis that specific modulatory signals shape memory formation into a state that lacks lability. We find that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of stability at the expense of lability in the amygdala.Preventing the NOR-LC from modulating strong fear encoding results in the formation of memories that can undergo reconsolidation within the amygdala and thus are vulnerable to postreactivation interference. Thus, the memory strength boundary condition on reconsolidation is set at the time of encoding by the action of the NOR-LC.

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Memory Reconsolidation

Cited by 68 publications

References 185 publications

Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies

Vagus nerve stimulation as a tool for enhancing extinction in exposure-based therapies

Regulation of Garcinol on Histone Acetylation in the Amygdala and on the Reconsolidation of a Cocaine-Associated Memory

Noradrenergic projections from the locus coeruleus to the amygdala constrain auditory fear memory reconsolidation

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