Memory processing by the limbic system: Role of specific neurotransmitter systems

Izquierdo, Iván; Medina, Jorge H.; Bianchin, Marino Muxfeldt; Walz, Roger; Zanatta, Marilene S.; Silva, Ricardo C. Da; Silva, Marcia Bueno e; Ruschel, Anelise C.; Paczko, Natalia

doi:10.1016/0166-4328(93)90093-6

Cited by 70 publications

(49 citation statements)

References 54 publications

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“…The hippocampus and amygdala enter into play at the time of training and in the period immediately after training, particularly in this task. The hippocampus is believed to be in charge of spatial, contextual and other cognitive aspects of memory of the training experience and the amygdala is believed to be in charge of the emotional aspects, particularly those of an aversive nature (6,17,18). The findings about muscimol given into the entorhinal cortex 90 or 180 min after training confirm those of Ferreira et al (3,4).…”

Section: Discussionsupporting

confidence: 78%

“…This observation suggests a role for these structures in different phases of memory consolidation (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 77%

“…Lesions and pharmacological manipulations of the hippocampus, amygdala and entorhinal cortex are known to have profound effects on memory consolidation and retrieval (1,(3)(4)(5)(6)(7)(8)(9). Lesions of the posterior parietal area in the rat have less dramatic, but also deleterious effects on spatial memory (10,11) and on at least some (11) but not all types of non-spatial memory (12).…”

Section: Introductionmentioning

confidence: 99%

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Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation

Zanatta¹,

Quillfeldt²,

Schaeffer³

et al. 1997

Braz J Med Biol Res

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A total of 182 young adult male Wistar rats were bilaterally implanted with cannulae into the CA1 region of the dorsal hippocampus and into the amygdaloid nucleus, the entorhinal cortex, and the posterior parietal cortex. After recovery, the animals were trained in a stepdown inhibitory avoidance task. At various times after training (0, 30, 60 or 90 min) the animals received a 0.5-µl microinfusion of vehicle (saline) or 0.5 µg of muscimol dissolved in the vehicle. A retention test was carried out 24 h after training. Retention test performance was hindered by muscimol administered into both the hippocampus and amygdala at 0 but not at 30 min posttraining. The drug was amnestic when given into the entorhinal cortex 30, 60 or 90 min after training, or into the parietal cortex 60 or 90 min after training, but not before. These findings suggest a sequential entry in operation, during the posttraining period, of the hippocampus and amygdala, the entorhinal cortex, and the posterior parietal cortex in memory processing.

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Section: Discussionsupporting

confidence: 78%

“…This observation suggests a role for these structures in different phases of memory consolidation (3)(4)(5)(6)(7)(8).…”

Section: Introductionmentioning

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation

Zanatta¹,

Quillfeldt²,

Schaeffer³

et al. 1997

Braz J Med Biol Res

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“…Adrenergic receptors found on vagal afferents project to the nucleus of the solitary tract and can subsequently activate neurons that project to the amygdala [11]. The amygdala has long been associated with the acquisition of memory related to aversive stimuli [11,13,25,31,34] and the modulation of memory processes involving the hippocampus [14,27,44]. Consequently, it is possible that in addition to enhancing the activity of non-cholinergic inputs to the hippocampus, administration of a mild aversive stimulus also activates parallel memory systems [29,47] that enhance performance, perhaps by strengthening the use of strategies less dependent on hippocampal cholinergic inputs.…”

Section: Potential Mechanisms and Implicationsmentioning

confidence: 99%

Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections

Fitz¹,

Gibbs²,

Johnson³

2006

Brain Research Bulletin

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Infusion of 192 IgG-saporin (SAP) into the medial septum (MS) of rats selectively destroys cholinergic neurons projecting to the hippocampus and impairs acquisition of a delayed matching to position (DMP) T-maze task. The present study evaluated whether introduction of a mild aversive stimulus 30 min prior to training would attenuate the deficit in DMP acquisition caused by the SAP lesions. Male Sprague-Dawley rats received medial septal infusions of either artificial cerebrospinal fluid or SAP (0.22 μg in 1.0 μl). Fourteen days later, all animals were trained to perform the DMP task. Half of the SAP-treated animals and controls received an intraperitoneal injection of saline each day, 30 min prior to training. Results show that intraperitoneal saline attenuated the impairment in DMP acquisition in SAP lesioned rats. These results suggest that a mild aversive stimulus can attenuate cognitive deficits caused by medial septal cholinergic lesions.

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“…Additionally, GABA-induced chloride conductance can also result from activation of the signal transduction pathway, which consequently phosphorylates certain subunits of the GABA-A receptor [40]. As GABA can impair memory by inhibiting the induction phase of long-term potentiation (LTP) [41], allopregnanolone could have a negative influence on the learning process [42,43]. On the other hand, GABA has a positive effect on cell survival in models of excitotoxicity [44].…”

Section: Non-genomic Effectsmentioning

confidence: 99%

Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease

Osmanovic-Barilar

Salkovic-Petrisi

2016

Drugs Aging

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Hormone therapy (HT) is prescribed during or after menopausal transition to replace the decline in estrogen and progesterone levels. While some studies indicate that estrogen and progesterone depletion in postmenopausal women might carry a significant risk for developing sporadic Alzheimer's disease (sAD), which may be reduced by HT, recent clinical trials oppose this beneficial effect. This review points to possible reasons for these mixed data by considering the issues of both preclinical and clinical trials, in particular the representativeness of animal models, timing of HT initiation, type of HT (different types of estrogen compound, estrogen monotherapy versus estrogen-progesterone combined therapy), mode of drug delivery (subcutaneous, transdermal, oral or intramuscular) and hormone dosage used, as well as the heterogeneity of the postmenopausal population in clinical trials (particularly considering their sAD stage, anti-AD therapy and hysterectomy status). Careful planning of future preclinical and clinical HT interventional studies might help to elucidate the effect of HT on cognitive status in postmenopausal women with sAD, which will eventually contribute to more effective sAD prevention and treatment. Key points:• The influence of hormone therapy (HT) on cognition in postmenopausal women with Alzheimer's disease (AD) is inconclusive mainly due to a translational gap based on inadequate animal models, clinical inter-/intra-group heterogeneity and often incomparable HT study design.• Cognitive outcomes in clinical trials are mostly influenced by HT composition, its dose, timing and route of administration, as well as by ApoE carrier status, co-morbidity and concomitant therapy.•Design of estrogen/progesterone modulators that would optimize cognitive benefits and tailored HT may lead to more successful prevention and treatment of AD in postmenopausal women.

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Memory processing by the limbic system: Role of specific neurotransmitter systems

Cited by 70 publications

References 54 publications

Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation

Involvement of the hippocampus, amygdala, entorhinal cortex and posterior parietal cortex in memory consolidation

Aversive stimulus attenuates impairment of acquisition in a delayed match to position T-maze task caused by a selective lesion of septo-hippocampal cholinergic projections

Evaluating the Role of Hormone Therapy in Postmenopausal Women with Alzheimer’s Disease

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