Memory outcome following left anterior temporal lobectomy in patients with a failed Wada test

Rathore, Chaturbhuj; Alexander, Aley; Sarma, P. Sankara; Radhakrishnan, Kurupath

doi:10.1016/j.yebeh.2015.02.011

Cited by 10 publications

(4 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, memory deficits in TLE are not universal, 14 nor is the degree of decline after surgical resection. 15 Many parameters have been studied to explain the variation in memory performance across TLE patients both pre-and postsurgery, including laterality (left/right) of seizure onset, 16 hemispheric dominance, 16 HS positive/negative status, 17,18 hippocampal volume, 19 degree of neuronal loss, 20 Wada test memory scores, [21][22][23][24] age at onset, 18,25 and duration of epilepsy, 25 to name a few. Yet study results remain mixed, predictive models are incomplete, and significant interindividual variation exists between patients in the same group.…”

Section: Introductionmentioning

confidence: 99%

Loss of hippocampal dentation in hippocampal sclerosis and its relationship to memory dysfunction

et al. 2022

View full text Add to dashboard Cite

Summary Objective Hippocampal dentation (HD) is a “toothlike” morphological feature observed on the inferior aspect of the human hippocampus. It has been found that HD varies dramatically in healthy adults and is positively associated with verbal and visual memory. In this work, we evaluate the loss of HD and its association with memory dysfunction in patients with temporal lobe epilepsy (TLE) who have hippocampal sclerosis (HS). Methods Fifty‐eight unilateral HS patients with neuropsychological data were identified from a retrospective database. T1‐weighted magnetization‐prepared rapid acquisition gradient echo images (~1 mm resolution) were upsampled to .25 mm and were processed using ASHS software to obtain ultra‐high‐resolution segmentations and three‐dimensional renderings. Dentes were counted on the epileptic and contralateral sides, and associations were tested between dentation on the epileptic versus contralateral sides and measures of verbal and visuospatial memory with respect to the dominant versus nondominant hemisphere. Results The median number of dentes in epileptic hippocampi was significantly lower than in contralateral hippocampi (p < .0001). Among cases with HS in the dominant hemisphere, verbal memory was significantly correlated with contralateral nondominant hemisphere dentation (r = .43, p = .04). Similarly, among cases of HS in the nondominant hemisphere, visual memory was significantly correlated with contralateral dominant hemisphere dentation (r = .48, p = .04). All other analyses were not significant. Significance This is the first study characterizing dentation in TLE patients with HS and its memory correlates. There is marked loss of dentation in sclerotic hippocampi compared to the unaffected contralateral hippocampi. Material‐specific measures of memory performance are paradoxically correlated with dentation contralateral to the side with HS, suggesting that contralateral functional capacity explains some of the variation in memory across TLE patients. HD is an important variable to consider in understanding memory loss in TLE.

show abstract

Section: Introductionmentioning

confidence: 99%

Loss of hippocampal dentation in hippocampal sclerosis and its relationship to memory dysfunction

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Impaired memory performance is usually found in about 20–30 % of cases injected ipsilateral to the seizure onset zone and in 60–80% after contralateral injection (117–119). Based on these results, several authors consider IAT results as a prognostic tool to predict postsurgical declarative memory, although results on the predictive value of IAT are contradictory and controversial (120–123), and memory results on repeated IAT are much less robust than those of verbal language testing (15).…”

Section: Eeg/meg Functional Cortical Mapping Compared To Other Methodsmentioning

confidence: 99%

“…Even though it is considered the gold standard, the role of IAT in the prediction of postoperative declarative memory outcome remains controversial. Rathore et al (123) reported memory outcome data on 116 patients after left anterior temporal lobe resection. Approximately one third of patients had “failed” IAT, meaning that test results indicated ipsilateral memory representation.…”

Section: Eeg/meg Functional Cortical Mapping Compared To Other Methodsmentioning

confidence: 99%

Presurgical Functional Cortical Mapping Using Electromagnetic Source Imaging

2019

View full text Add to dashboard Cite

Preoperative localization of functionally eloquent cortex (functional cortical mapping) is common clinical practice in order to avoid or reduce postoperative morbidity. This review aims at providing a general overview of magnetoencephalography (MEG) and high-density electroencephalography (hdEEG) based methods and their clinical role as compared to common alternatives for functional cortical mapping of (1) verbal language function, (2) sensorimotor cortex, (3) memory, (4) visual, and (5) auditory cortex. We highlight strengths, weaknesses and limitations of these functional cortical mapping modalities based on findings in the recent literature. We also compare their performance relative to other non-invasive functional cortical mapping methods, such as functional Magnetic Resonance Imaging (fMRI), Transcranial Magnetic Stimulation (TMS), and to invasive methods like the intracarotid Amobarbital Test (WADA-Test) or intracranial investigations.

show abstract

“…For example, Elshorst et al 28 concluded that WT scores were of no added value for the prediction of postsurgical change in verbal memory function and identified the etiology of epilepsy and the patients’ presurgical cognitive performance to be the only significant predictor variables in their multivariate model. Additionally, reports of false-positive WT results (i.e., falsely predicting postsurgical memory impairment) 29 and limited reproducibility of Wada HML results 30 advanced skepticism towards the predictive value of WT results.…”

Section: Introductionmentioning

confidence: 99%

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Conradi

Rosenberg

Knake

et al. 2021

Sci Rep

View full text Add to dashboard Cite

In recent years, the clinical usefulness of the Wada test (WT) has been debated among researchers in the field. Therefore, we aimed to assess its contribution to the prediction of change in verbal learning and verbal memory function after epilepsy surgery. Data from 56 patients with temporal lobe epilepsy who underwent WT and subsequent surgery were analyzed retrospectively. Additionally, a standard neuropsychological assessment evaluating attentional, learning and memory, visuospatial, language, and executive function was performed both before and 12 months after surgery. Hierarchical linear regression analyses were used to determine the incremental value of WT results over socio-demographic, clinical, and neuropsychological characteristics in predicting postsurgical change in patients’ verbal learning and verbal memory function. The incorporation of WT results significantly improved the prediction models of postsurgical change in verbal learning (∆R2 = 0.233, p = .032) and verbal memory function (∆R2 = 0.386, p = .005). Presurgical performance and WT scores accounted for 41.8% of the variance in postsurgical change in verbal learning function, and 51.1% of the variance in postsurgical change in verbal memory function. Our findings confirm that WT results are of significant incremental value for the prediction of postsurgical change in verbal learning and verbal memory function. Thus, the WT contributes to determining the risks of epilepsy surgery and, therefore, remains an important part of the presurgical work-up of selected patients with clear clinical indications.

show abstract

Memory outcome following left anterior temporal lobectomy in patients with a failed Wada test

Cited by 10 publications

References 41 publications

Loss of hippocampal dentation in hippocampal sclerosis and its relationship to memory dysfunction

Loss of hippocampal dentation in hippocampal sclerosis and its relationship to memory dysfunction

Presurgical Functional Cortical Mapping Using Electromagnetic Source Imaging

Wada test results contribute to the prediction of change in verbal learning and verbal memory function after temporal lobe epilepsy surgery

Contact Info

Product

Resources

About