Memory interference in multiple sclerosis

Griffiths, Stephanie; Yamamoto, Aiko; Boudreau, Vanessa G.; Ross, Leslie; Kozora, Elizabeth; Thornton, Allen E.

doi:10.1017/s135561770505085x

Cited by 19 publications

(15 citation statements)

References 74 publications

(94 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Diffuse white matter pathology is likely to negatively impact virtually all aspects of cognitive functioning and consistent with this possibility, deficits in executive functioning, speed of information processing, attention, and retrospective memory have been identified (Beatty et al, 1989;Beatty et al, 1993;Griffiths et al, 2005;Henry & Beatty, 2006). However, deficits in memory are among the most consistently reported findings, and in their meta-analytic review of short-term, long-term, and working memory, Thornton and Raz (1997) concluded that MS is associated with significant impairment on all three types of retrospective memory.…”

Section: Introductionmentioning

confidence: 78%

Prospective memory in multiple sclerosis

Rendell

Jensen

Henry

2007

J. Inter. Neuropsych. Soc.

View full text Add to dashboard Cite

There is considerable evidence that multiple sclerosis (MS) is associated with impaired retrospective memory. However, although preliminary evidence suggests that prospective memory is also affected by the disorder, the degree and nature of the impairment remains to be clarified. Twenty participants with MS were compared with 20 matched controls on Virtual Week, a measure of prospective memory that closely represents the types of prospective memory tasks that actually occur in everyday life, and provides an opportunity to investigate the different sorts of prospective memory failures that occur. The results indicated that irrespective of the specific prospective memory task demands, MS participants' performance was significantly impaired relative to controls. MS deficits could not be attributed to problems with retrospective memory because MS participants in the present study did not differ significantly from controls on measures of long-and short-term memory, and significant impairment was observed on a prospective memory task, which imposed only minimal demands on retrospective memory. These results therefore suggest that individuals with MS may experience general difficulties with prospective memory. The practical and theoretical implications of these findings are discussed. (JINS, 2007, 13, 410-416.)

show abstract

Section: Introductionmentioning

confidence: 78%

Prospective memory in multiple sclerosis

Rendell

Jensen

Henry

2007

J. Inter. Neuropsych. Soc.

View full text Add to dashboard Cite

show abstract

“…No passado, admitiu-se que a redução de memória era causada por distúrbios de evocação da informação. As pesquisas mais recentes sugerem que o comprometimento da memória emerge de prejuízo nos processos de armazenamento da informação e decodificação (Benedict & Zivadinov, 2006;Diamond, Johnson, Kaufman, & Graves, 2008;Griffiths et al, 2005). Dessa forma, talvez as cinco tentativas de aprendizagem do RAVLT tenham sido insuficientes para os pacientes com EM codificarem a informação e recordarem (Winkelmann et al, 2007).…”

Section: Discussionunclassified

“…A interferência pró-ativa foi considerada como sendo aquela que ocorre quando uma nova informação impede a retenção de uma aprendizagem anterior, enquanto que se admitiu por interferência retroativa a redução de retenção de informações previamente aprendidas causada por aprendizagens subseqüentes (Griffiths et al, 2005).…”

Section: Instrumentosunclassified

Avaliação das funções cognitivas de atenção, memória e percepção em pacientes com esclerose múltipla

Freitas¹,

Aguiar²

2012

Psicol. Reflex. Crit.

View full text Add to dashboard Cite

ResumoEsclerose múltipla é uma doença desmielinizante, que leva à destruição de importantes estruturas do Sistema Nervoso Central. Essas lesões podem resultar em déficits cognitivos. Com o objetivo de investigar a relação entre esclerose múltipla e alterações cognitivas de atenção, memória e percepção, foram avaliados 28 pacientes em um Centro Estadual de Referência, que satisfaziam os critérios de inclusão: idade entre 20 e 55 anos, nível escolar mínimo de 2 o grau completo e classificação na Escala Expandida de Incapacidade menor que 7,0. Foram empregados quatro testes neuropsicológicos, validados pelo Conselho Federal de Psicologia: teste da cópia e reprodução de memória da figura complexa A de Rey-Osterrieth, teste de aprendizagem áudio-verbal de Rey, teste d2 e teste de dígitos. Para investigar o impacto da fadiga sobre as atividades cognitivas foi utilizada a escala MFIS-21Br. A análise estatística consistiu dos testes ANOVA, t para amostras pareadas ou de Mann-Whitney e de Kolmogorov-Smirnoff, unicaudais à direita, para rejeição da hipótese nula com nível de significância de 0,05. Os resultados apontaram perdas cognitivas com significância estatística nos pacientes com idade entre 40 e 55 anos e nos que apresentaram comprometimento por fadiga nos subdomínios cognitivo e psicossocial. Os pacientes com tempo de doença entre 5,0 e 19,9 anos apresentaram redução da pontuação nos testes, mas sem significância estatística. Concluiu-se que, dentre as funções cognitivas avaliadas, memória foi a mais freqüentemente comprometida, seguindo-se de atenção, sendo a percepção, comparativamente, a mais preservada. Palavras-chave: Esclerose múltipla, déficits cognitivos, atenção, memória, percepção. AbstractMultiple sclerosis is a demyelinating disease that leads to the destruction of important structures of the Central Nervous System. These lesions may result in cognitive deficits. Aiming to investigate the relation between multiple sclerosis and cognitive alterations of attention, memory and perception 28 patients have been evaluated in a State Reference Center. They satisfied the following inclusion criteria: age between 20 and 55 years old, minimum scholarship level of High School and classification in the Expanded Disability Status Scale minor than 7.0. Four neuropsychological tests, validated by Federal Council of Psychology, were used: copy and memory reproduction of Rey-Osterrieth Complex Figure Test, Rey Audio-Verbal Learning Test, d2 Test and Digit-Span Test. To investigate the impact of fatigue on cognitive activities, MFIS-21Br scale was used. Statistical analysis consisted of ANOVA, pared samples t test or Mann-Whitney test, and Kolmogorov-Smirnoff test, right sided, for rejection of null hypothesis with significance level of .05. The results pointed out statistically significant cognitive losses for patients between 40 and 55 years old as well as for those who presented detriment due to fatigue in cognitive and psychosocial subdomains. Patients with disease duration between 5.0 and 19.9 years presented reduc...

show abstract

“…When considering episodic memory abilities, it is usual to dissociate, on the one end, the long-term maintenance of information over the period of a few minutes to a lifetime (storage). On the other hand, the manipulation of information, which may include multiple executive sub-processes such as encoding, retrieval, sensitivity to interference and learning strategy [7][8][9].While executive impairments can be targeted by cognitive intervention, storage deficits are more likely to require prosthetic strategies (agenda or other external help).…”

Section: Introductionmentioning

confidence: 99%

“…Among the most comprehensive studies [7,8,21,[23][24][25][26]28], only Diamond and colleagues [21] and Stegen and colleagues [8] exhaustively reported on raw scores. In a large sample (351 patients), the latter study reported impaired performances for all the described indices.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis?

Amaya¹,

Bakchine²,

Igor³

2013

J Mult Scler

View full text Add to dashboard Cite

Objective: Various verbal episodic memory impairments have been demonstrated in multiple sclerosis (MS), including encoding, retrieval and storage processes. Our clinical experiment suggests that a subset of MS patients may show another pattern with a distinctive evolution of performances after a 20 minutes delay (short-delay versus long-delay free recall). Methods:The current study assessed performances on the California Verbal Learning Test (CVLT) in MS with a special focus on evolution after delay to identify a subgroup of patients who may show a significant spontaneous improvement of long-delay free recall in comparison with short-delay free recall. Data from 52 MS patients were compared with those from 32 controls. Group analyses were conducted on classical scores. Individual MS performances were also analyzed, according to confidence intervals calculated using control data.Results: From individual analysis, memory comorbidities were frequently observed in a MS patient (17% of MS patients had only one impaired score, 17% had two or three scores, 27% had four or five scores and 38% had six or more). Regarding the evolution after delay, three profiles were highlighted: two classical (stable and worsening, i.e. storage deficit) and a third showing a significant degree of improvement. The improvement was significantly correlated with processing speed, primacy effect and sensitivity to retroactive interference only in this third MS subgroup. This benefit from delay was not related to the effect of semantic clustering. Conclusion:The current study suggests that a subgroup of MS patients might present a previously unreported abnormal long-term memory profile, in which an impaired short-term performance contrasts with a significant spontaneous improvement with delay. Previous studies have demonstrated the relevance of spaced learning in MS rehabilitation. If our results are corroborated in a larger sample, the CVLT may help to select patients that are likely to benefit from this temporal memory care.

show abstract

Memory interference in multiple sclerosis

Cited by 19 publications

References 74 publications

Prospective memory in multiple sclerosis

Prospective memory in multiple sclerosis

Avaliação das funções cognitivas de atenção, memória e percepção em pacientes com esclerose múltipla

Abnormal Long-Term Episodic Memory Profiles in Multiple Sclerosis?

Contact Info

Product

Resources

About