Memory in an Eight-Channel Radial Maze is Better in High-Impulsivity Rats Than Low-Impulsivity Animals

Зайченко, М. И.; Sharkova, Anna; Grigoryan, G. A.; Merzhanova, G. Kh.

doi:10.1007/s11055-017-0538-4

Cited by 5 publications

(3 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This model is widely used to study spatial working memory and spatial reference in animals. Working memory (WM) is referred to a critical cognitive domain required for the representation of objects or places during goal-directed behaviour [19]. Alternatively, reference memory (RM) is required for temporally stable representations of those objects or places.…”

Section: Discussionmentioning

confidence: 99%

“…Prior to the experiment, the animals were maintained on a restricted feedings schedule designed to keep their body weight at about 85% of the free-feeding level, with water being available ad libitum . Before the training began, each mouse was simultaneously subjected to the task and allowed to explore for 5 min and take food freely [19]. The food was initially available throughout the maze, but was gradually restricted to the food cup.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract ofZiziphus mucronata(Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice

Foyet

Wado

Abaïssou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Ziziphus mucronata Willd, also known as “buffalo thorn,” belongs to the family Rhamnaceae. Its bark and leaves are used in folk medicine for the treatment of various deficiencies related to nociception, inflammation, mood, and depression. Still, there is a lack of scientific data regarding its potential effect on learning and memory process. The present study was designed to investigate the neuroprotective potential of Ziziphus mucronata (ZM) on learning and memory impairment in a scopolamine-induced model of dementia in mice. The phytochemical analysis revealed five cyclopeptide alkaloids (sanjoinines) in the extract from Ziziphus Mucronata leaves using LC-HRMS, and the structural characterization of these compounds was determined via MS/MS. Alzheimer-type amnesia was induced by an intraperitoneal injection of scopolamine (1 mg/kg) to mice for 7 consecutive days. ZM (150 mg/kg, 300 mg/kg, and 600 mg/kg) and piracetam (150 mg/kg) were orally administrated to mice daily for a period of 14 days. Memory-related behavioural parameters were evaluated using the radial arm maze task for 7 days, Y-maze, and novel object recognition task. At the end of protocol schedule, animals were sacrificed, and the levels of acetylcholinesterase, malondialdehyde, catalase, and superoxide dismutase were determined in brain homogenates. Histological studies of the hippocampus were subsequently performed. The long-term scopolamine-injected group decreased the spontaneous alternation (Y-maze), the discrimination index, and the time taken to explore the new object (novel object recognition task). These effects were significantly reversed by ZM at all the doses tested. In the radial arm maze task, ZM (300 and 600 mg/kg) significantly decreased the working and reference memory errors when compared with the demented group. Scopolamine-mediated changes in AChE activity were also attenuated by ZM in mice. In addition, extract-treated groups showed a significant increase in the level of CAT and SOD activity and decreased levels of MDA in the mice brains, as compared with the control group. The present study suggests that ZM could have an important role in neuroprotection on this scopolamine-induced model of Alzheimer-type dementia.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract ofZiziphus mucronata(Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice

Foyet

Wado

Abaïssou

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…Биологические исследования позволили установить ряд эффектов, подтверждающих действие дистанционного эмоционального резонанса [1,5,12,13]. В экспериментальной физиологии и психофизиологии активно используются различные модификации теста «эмоциональный резонанс» [8,16,18]. Тест предназначен для оценки степени сопереживания одной особью отрицательного эмоционального состояния другой особи, находящейся под влиянием негативных воздействий, и возможностью своим действием минимизировать такие воздействия [10].…”

unclassified

Reactivity of the Vegetative Nervous System Influenced by Non-Verbal Information

Baiguzhin

Шибкова

Kudryashov

et al. 2019

hsm

View full text Add to dashboard Cite

Aim. The article deals with establishing the HRV indicators influenced by non-verbal information. Materials and methods. Vegetative nervous system reactions have been estimated under the influence of non-verbal information as a response to the emotional state of the passive repeaters. The functional status of the repeaters was influenced by an emotional video. A recipient was in an isolated room surrounded by the group of the passive repeaters and was not subjected to a direct influence of the emotional video. The assessment of the vegetative responses in repeaters has been performed using tone- and pulsometry, in recipients – using the mathematical and time-domain analysis of a cardiorhythmogram. ECG recording was synchronized with video demonstration and divided into 9 conditional stages, each of 100 cardiocycles. The reliability of differences has been assessed with the Wilcoxon non-parametric criterion. Results. The intensity of vegetative nervous system reactions in both groups has been registered during the stages preceded by a video demonstration. In recipients, the high frequency of the significant changes in RRNN, RMSSD, pNN50, HR, M, Mo, AMo, VRI proves body sensitivity to non-verbal information. The low variability of certain indicators such as VR, SDNN, AMo, VB, and SI allows us to establish their specificity. Conclusion. The presence and intensity of a vegetative reaction in the recipients is determined by the modality of the emotion formed in a passive repeater. This effect can be possibly considered as an emotional resonance in the recipient induced by asthenic emotions and the feeling of compassion and regret in the repeater as a response to an emotional video.

show abstract

Pigeon Robot for Navigation Guided by Remote Control: System Construction and Functional Verification

et al. 2021

View full text Add to dashboard Cite

Memory in an Eight-Channel Radial Maze is Better in High-Impulsivity Rats Than Low-Impulsivity Animals

Cited by 5 publications

References 17 publications

Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract ofZiziphus mucronata(Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice

Anticholinesterase and Antioxidant Potential of Hydromethanolic Extract ofZiziphus mucronata(Rhamnaceae) Leaves on Scopolamine-Induced Memory and Cognitive Dysfunctions in Mice

Reactivity of the Vegetative Nervous System Influenced by Non-Verbal Information

Pigeon Robot for Navigation Guided by Remote Control: System Construction and Functional Verification

Contact Info

Product

Resources

About