Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement

Macpherson, Helen; Ellis, Kathryn A.; Sali, Avni; Pipingas, Andrew

doi:10.1007/s00213-011-2481-3

Cited by 64 publications

(102 citation statements)

References 67 publications

(81 reference statements)

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“…Furthermore, we demonstrated that the gamma-GCS activity, the first enzyme in the GSH biosynthesis, was upregulated in the prefrontal cortex of LDLr -/mice regardless of age, signaling an upregulation of GSH biosynthesis [84]. In this context, antioxidants have been shown to reverse learning and memory deficits observed in aging mice and in experimental models of Alzheimer's disease [85,86]. For instance, Farr et al [87] showed that natural antioxidants of extra virgin olive oil have beneficial effects on learning and memory deficits of SAMP8 mice (a model of agerelated learning/memory impairments) by reversing oxidative damage in the brain.…”

Section: Discussionmentioning

confidence: 86%

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

Moreira

Oliveira

Nunes

et al. 2012

JAD

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There is increasing evidence that hypercholesterolemia during midlife may represent a predictor of subsequent mild cognitive impairments and dementia decades later. However, the exact mechanism underlying this phenomenon remains unknown since plasmatic cholesterol is not able to cross the blood-brain barrier. In the present study, we evaluated the hypothesis that cognitive impairments triggered by hypercholesterolemia during aging may be related to brain oxidative stress and altered brain acetylcholinesterase (AChE) activity. We also performed a neuropathological investigation in order to analyze whether the cognitive impairments may be associated with stroke-related features. To address these questions we used three- and fourteen-month-old low-density lipoprotein receptor-deficient mice (LDLr-/-). The current findings provide new evidence that aged LDLr-/- mice, exposed to over three-fold cholesterol levels from early life, show working, spatial reference, and procedural memory impairments, without alterations in motor function. Antioxidant imbalance and oxidative damage were evidenced by a marked increase in lipid peroxidation (thiobarbituric acid reactive substances levels) and glutathione metabolism (increase in glutathione levels, glutathione reductase, and glutathione peroxidase activities) together with a significant increase in the AChE activity in the prefrontal cortex of aged hypercholesterolemic LDLr-/- mice. Notably, hypercholesterolemia was not related to brain infarcts and neurodegeneration in mice, independent of their age. These observations provide new evidence that hypercholesterolemia during aging triggers cognitive impairments on different types of learning and memory, accompanied by antioxidant imbalance, oxidative damage, and alterations of cholinergic signaling in brain areas associated with learning and memory processes, particularly in the prefrontal cortex.

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Section: Discussionmentioning

confidence: 86%

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

Moreira

Oliveira

Nunes

et al. 2012

JAD

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“…The same treatment was associated with improvements in contextual recognition memory performance in men aged between 50 and 74 years who had a sedentary lifestyle [10]. Macpherson et al [26], also showed that 16-week supplementation with a SMV formula designed for older women (50+ Ultivite®) was associated with faster speed of spatial working memory performance.…”

Section: Introductionmentioning

confidence: 99%

Participant experiences from chronic administration of a multivitamin versus placebo on subjective health and wellbeing: a double-blind qualitative analysis of a randomised controlled trial

Sarris

Cox

Camfield

et al. 2012

Nutr J

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BackgroundWhile many randomised controlled trials have been conducted on multivitamins, to our knowledge no qualitative research exploring the subjective experience of taking a multivitamin during a clinical trial has been reported.MethodsSemi-structured and open-ended written questions were incorporated into a 16-week double-blind, randomised, placebo-controlled, parallel groups trial of once-daily multivitamin administration. At the final study visit (week 16), three open-ended questions were posed to elucidate any positive, negative or unusual experiences from taking either the multivitamin or matched placebo. Qualitative thematic analysis was undertaken by researchers who were blind as to treatment condition of participants, and triangulation (independent analysis from three researchers) was employed to ensure methodological rigour. Participant’s experiences were categorised as “positive” or “negative” and a Chi Square analysis was then applied to each of the experiential themes, to compare experiences between the multivitamin and placebo groups, (subdividing the groups by gender). Usual experiences were categorised and discussed separately.ResultsOf the 182 participants enrolled, 116 completed the study and qualitative data were available from 114 participants. Thematic analysis revealed significant effects in favour of the multivitamin over placebo for participants experiencing increased energy levels (p=.022) and enhanced mood (p=.027). The beneficial effect on energy levels was particularly evident among female participants. A trend was found for participants reporting better sleep in the multivitamin over placebo. The multivitamin and placebo groups did not significantly differ in perceived positive or negative effects in areas relating to other aspects of mental function or physical health. No significant negative effects were revealed, although there was a non-significant trend for more people in the multivitamin group having minor digestive complaints.ConclusionThis represents the first documented qualitative investigation of participants’ experience of chronic administration of a multivitamin. Results uncovered a range of subjective beneficial effects that are consistent with quantitative data from previously published randomised controlled trials examining the effects of multivitamins and B vitamin complexes on mood and well-being.Trial registrationPrior to commencement this trial was registered with the Australian New Zealand Clinical Trials Registry ( http://www.anzctr.org.au) ACTRN12611000092998

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“…A recent meta-analysis found evidence that supplementation with multivitamins reduces the odds of cognitive decline, potentially also linked to the development of Alzheimer's disease [ 36 ] . Multivitamins were reported to slow down the progression of cognitive decline in elderly women [ 37 ] . Moreover, increased intakes of vitamins were also linked to alertness, general well-being and a reduction in negative mood-swings in elderly men [ 38 ] .…”

Section: Micronutrients and Cognitive Functionsmentioning

confidence: 99%

The Role of Vitamins in Aging Societies

Troesch

Eggersdorfer

Weber

2012

International Journal for Vitamin and Nutrition Research

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Raising numbers of elderly lead to a dramatic shift in demographics, accompanied by an increase in non-communicable diseases such as cancer, cardiovascular disease and dementia. All these conditions are thought to be modifi able by diet to some degree and mounting evidence indicates that improved intakes of certain vitamins can slow their progress. Strong evidence exists for the benefi cial effect of vitamin D on the risk of bone fractures. Moreover, as chromosomal damage is a risk factor for dementia, supplementation with nutrients preventing these impairments are thought to have a benefi cial effect on cognitive decline. However, the aging progress strongly affects nutrient intakes and utilisation due to social, physical and psychological changes. Data from dietary surveys suggest that many of the elderly in Europe have intakes for various vitamins that are well below the recommendations. The situation appears to be even more critical for elderly in institutions such as care homes. Given the increasing number of elderly and the importance of an adequate supply with vitamins, more research is warranted to fi nd nutritional solutions to improve their wellbeing and health -which in the long run can be expected to contribute to reduce the ever increasing health care costs.

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Memory improvements in elderly women following 16 weeks treatment with a combined multivitamin, mineral and herbal supplement

Abstract: Sixteen weeks ssupplementation with a combined multivitamin, mineral and herbal formula may benefit working memory in elderly women at risk of cognitive decline.

Cited by 64 publications

References 67 publications

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

Age-Related Cognitive Decline in Hypercholesterolemic LDL Receptor Knockout Mice (LDLr−/−): Evidence of Antioxidant Imbalance and Increased Acetylcholinesterase Activity in the Prefrontal Cortex

Participant experiences from chronic administration of a multivitamin versus placebo on subjective health and wellbeing: a double-blind qualitative analysis of a randomised controlled trial

The Role of Vitamins in Aging Societies

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