Memory function in childhood epilepsy syndromes

Nolan, Melinda; Redoblado, M. A.; Lah, Sunčica; Sabaz, Mark; Lawson, John A.; Cunningham, Anne M.; Bleasel, Andrew; Bye, Ann

doi:10.1111/j.1440-1754.2004.00284.x

Cited by 155 publications

(131 citation statements)

References 36 publications

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“…Some authors found that verbal memory deficit is correlated with left TLE and visual memory deficit is correlated with right TLE [10][11] . Nevertheless, other authors found correlation only between visual memory deficit and right TLE 11,12 . This is not in keeping with studies that showed a higher sensitivity of verbal memory tests in the assessment of left TLE in adults 3,6,13 .…”

mentioning

confidence: 83%

Memory in children with symptomatic temporal lobe epilepsy

Guimarães

Rzezak

Fuentes

et al. 2014

Arq. Neuro-Psiquiatr.

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In children with temporal lobe epilepsy (TLE), memory deficit is not so well understood as it is in adults. The aim of this study was to identify and describe memory deficits in children with symptomatic TLE, and to verify the influence of epilepsy variables on memory. We evaluated 25 children with TLE diagnosed on clinical, EEG and MRI findings. Twenty-five normal children were compared with the patients. All children underwent a neuropsychological assessment to estimate intellectual level, attention, visual perception, handedness, and memory processes (verbal and visual: short-term memory, learning, and delayed recall). The results allowed us to conclude: besides memory deficits, other neuropsychological disturbances may be found in children with TLE such as attention, even in the absence of overall cognitive deficit; the earlier onset of epilepsy, the worse verbal stimuli storage; mesial lesions correlate with impairment in memory storage stage while neocortical temporal lesions correlate with retrieval deficits.Keywords: neuropsychology, epilepsy, children, childhood, temporal lobe epilepsy, memory. RESUMOEm crianças com epilepsia de lobo temporal (ELT) os problemas de memória não são tão bem compreendidos como em adultos. O objetivo desse estudo foi identificar e descrever déficits de memória em crianças com ELT sintomática e verificar a influência de variáveis da epilepsia na memória. Avaliamos 25 crianças com ELT com diagnóstico baseado em aspectos clínicos, eletrencefalográficos e de neuroimagem. Vinte e cinco crianças normais foram comparadas com os pacientes. Todas as crianças foram submetidas à avaliação neuropsicológica para estimar nível intelectual, atenção, percepção visual, dominância manual, e processos de memória (verbal e visual: memória a curto prazo, aprendizado e recuperação tardia). Os resultados nos permitiram concluir que: além de déficit de memória, outros distúrbios neuropsicológicos podem ser encontrados em crianças com ELT, tais como déficit de atenção, mesmo na ausência de déficit cognitivo global; quanto mais precoce o início da epilepsia, pior o armazenamento verbal; lesões mesiais se correlacionam com prejuízo no armazenamento de memória enquanto lesões temporais neocorticais se correlacionam com prejuízos de evocação.Palavras-chave: neuropsicologia, epilepsia, crianças, infância, epilepsia de lobo temporal, memória.

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confidence: 83%

Memory in children with symptomatic temporal lobe epilepsy

Guimarães

Rzezak

Fuentes

et al. 2014

Arq. Neuro-Psiquiatr.

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“…Because the epilepsy groups performed worse than controls on all Indices, FSIQ was used as a covariate unless otherwise noted in order to determine whether there are impairments in learning/memory that go beyond IQ deficits. Other studies examining memory functioning in children with epilepsy have used it as a covariate as well (e.g., Borden et al, 2006;Kernan et al, 2012;Nolan et al, 2004), so our using it helps facilitate comparisons across studies.…”

Section: Preliminary Analysesmentioning

confidence: 99%

“…Relatedly, these children also tend to exhibit problems with semantic memory (Cormack et al, 2012;Jambaque, et al, 1993). Some researchers have found right TLE to be associated with visual learning/short-term memory problems for spatial arrangements, patterns, and geometric designs (Fedio & Mirsky, 1969;Nolan et al, 2004), as well as with visual long-term memory problems (Giovagnoli, Casazza, & Avanzini, 1995;Svoboda, 2004). Right TLE also is associated with poor memory for faces, as noted above.…”

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confidence: 99%

There Are Laterality Effects in Memory Functioning in Children/Adolescents With Focal Epilepsy

Kibby

Cohen

Lee

et al. 2014

Developmental Neuropsychology

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“…Jambaque et al (1993) evaluated 28 children with TLE and found that the correlation between visual memory deficit and right TLE was stronger than the correlation between verbal memory impairment and left TLE (16) . Poor visual memory performance was also found when patients with right mesial temporal sclerosis were assessed (18)(19) . The authors did not find differences in performance of the two groups (right versus left mesial temporal sclerosis) when verbal tests were used.…”

mentioning

confidence: 99%

“…When tumor and mesial temporal sclerosis are compared, differences may not be found (24) . There appears to be a negative influence of the duration of epilepsy on mnemonic functions (11,16,19) . Studies performed in adults reinforce this correlation, showing that a better neuropsychological performance is achieved in patients with a shorter duration of epilepsy (2,25) .…”

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confidence: 99%

Memory impairment in children with temporal lobe epilepsy: a review

Guimarães

Rzezak

et al. 2006

J. epilepsy clin. neurophysiol.

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Introduction:The authors present a review article on memory aspects of temporal lobe epilepsy in childhood. Methods: We performed a search in the literature. Results: Temporal lobe epilepsy (TLE) in childhood present with great clinical, electroencephalographic and etiological diversity. The neuropsychological features in children with TLE are not well-defined yet. The relationship between the lateralization of the lesion and performance on memory tests is not established. Conclusion: The studies performed in children with TLE show controversy data. This finding may be due to the etiological, clinical and electroencephalographic diversity seen in such group of children. Besides, most studies use different assessments. Therefore, it is clear that more studies are necessary to elucidate which neuropsychological deficits occur in children with TLE.

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Memory function in childhood epilepsy syndromes

Cited by 155 publications

References 36 publications

Memory in children with symptomatic temporal lobe epilepsy

Memory in children with symptomatic temporal lobe epilepsy

There Are Laterality Effects in Memory Functioning in Children/Adolescents With Focal Epilepsy

Memory impairment in children with temporal lobe epilepsy: a review

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