volume 25, issue 3, P433-444 2011
DOI: 10.3233/jad-2011-101944
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Avdesh Avdesh, Patrick Wong, Ralph N. Martins, Mathew T. Martin-Iverson

Abstract: The E4 allele of the apolipoprotein E (ApoE) gene has been identified as a major risk factor for the development of late onset Alzheimer's disease (AD). However, the mechanisms by which this gene affects AD are not fully understood. Studies of ApoE knock-out (ApoE KO) mice have revealed an exacerbation of two major pathologies that are diagnostic of AD: neurofibrillary tangles and senile plaques. However, evidence as to whether these mice have cognitive deficits is not yet conclusive. This ambiguity may arise …

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