Memory for the Order of Events in Specific Sequences: Contributions of the Hippocampus and Medial Prefrontal Cortex

DeVito, Loren M.; Eichenbaum, Howard

doi:10.1523/jneurosci.4202-10.2011

Cited by 142 publications

(137 citation statements)

References 34 publications

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“…The present results demonstrated that even the sequence of colors can be learned and that this learning involved the hippocampus although the resulting memory was implicit. This result is in accord with the proposed role of the hippocampus for the formation of sequential knowledge (Devito and Eichenbaum, 2011) and with models that focused on the relational binding as the core memory process of the hippocampus independent of implicit or explicit forms of memory .…”

Section: Discussionsupporting

confidence: 87%

Functional Dissociation of Hippocampal Mechanism during Implicit Learning Based on the Domain of Associations

Rose¹,

Haider²,

Salari³

et al. 2011

J. Neurosci.

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Traditionally, the medial temporal lobe (MTL) was linked to explicit or declarative memory in associative learning. However, recent studies have reported MTL involvement even when volunteers are not consciously aware of the learned contingencies. Therefore, the mechanism of the MTL-related learning process cannot be described sufficiently by the explicit/implicit distinction, and the underlying process in the MTL for associative learning needs a more functional characterization. A possible feature that would allow a functional specification also for implicit learning is the nature of the material that is learned. Given that implicit memory tasks often comprise a combination of perceptual and motor learning, we hypothesized that implicit learning of the perceptual but not the motor component entails MTL activation in these studies. To directly test this hypothesis, we designed a purely perceptual and a purely motor variant of the serial reaction time task. In two groups of human volunteers, behavioral results clearly showed that both variants were learned without awareness. Neuronal recordings using fMRI revealed that bilateral hippocampal activation was observed only for implicit learning of the perceptual sequence, not for the motor sequence. This dissociation clearly shows that the functional role of the hippocampus for learning is determined by the domain of the learned association and that the function of the medial temporal lobe system is the processing of contingencies between perceptual features regardless of the explicit or implicit nature of the ensuing memory.

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Section: Discussionsupporting

confidence: 87%

Functional Dissociation of Hippocampal Mechanism during Implicit Learning Based on the Domain of Associations

Rose¹,

Haider²,

Salari³

et al. 2011

J. Neurosci.

View full text Add to dashboard Cite

show abstract

“…Nevertheless, sequence memory has successfully been implemented in models of episodic-like memory (Ergorul & Eichenbaum, 2004), and been demonstrated to rely on the hippocampus Devito & Eichenbaum, 2011;, which has been shown to be a critical part of the network that processes episodic memory (Burgess, Maguire, & O'Keefe, 2002;Squire & Zola-Morgan, 1991;VarghaKhadem, 1997). Data from the current experiment might help to explain these findings.…”

Section: Discussionmentioning

confidence: 99%

Disambiguating past events: Accurate source memory for time and context depends on different retrieval processes

Persson

Ainge

O'Connor

2016

Neurobiology of Learning and Memory

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Please cite this article as: Persson, B.M., Ainge, J.A., O'Connor, A.R., Disambiguating past events: Accurate source memory for time and context depends on different retrieval processes, Neurobiology of Learning and Memory (2016), doi: http://dx.doi.org/10. 1016/j.nlm.2016.05.002 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. These models aim to capture the testable features of the definition of human episodic memory which stresses the temporal component of the memory as a unique piece of source information that allows us to disambiguate one memory from another. Recently though, it has been suggested that a more accurate model of human episodic memory would include contextual rather than temporal source information, as humans' memory for time is relatively poor. Here, two experiments were carried out investigating human memory for temporal and contextual source information, along with the underlying dual process retrieval processes, using an immersive virtual environment paired with a 'Remember-Know' memory task. Experiment 1 (n = 28) showed that contextual information could only be retrieved accurately using recollection, while temporal information could be retrieved using either recollection or familiarity.Experiment 2 (n = 24), which used a more difficult task, resulting in reduced item recognition rates and therefore less potential for contamination by ceiling effects, replicated the pattern of results from Experiment 1. Dual process theory predicts that it should only be possible to retrieve source context from an event using recollection, and our results are consistent with this prediction. That temporal information can be retrieved using familiarity alone suggests that it may be incorrect to view temporal context as analogous to other typically used source contexts. This latter finding supports the alternative proposal that time since presentation may simply be reflected in the strength of memory trace at retrieval -a measure ideally suited to trace strength interrogation using familiarity, as is typically conceptualised within the dual process framework.

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“…In rodents, mPFC lesions impair various forms of spatial memory (Lee and Kesner 2003;Jo et al 2007; Lee and Solivan 2008;Churchwell et al 2010). The mPFC has also been shown to be involved in a number of nonspatial memory tasks, including fear conditioning and extinction (Sotres-Bayon and Quirk 2010), transitive inference (DeVito et al 2010), and memory for sequential order (DeVito and Eichenbaum 2011). Although these studies clearly suggest that the mPFC is involved in typical rodent memory tasks, there is currently no consensus about the precise contribution of the PFC to memory encoding and retrieval processes.…”

mentioning

confidence: 99%

The medial prefrontal cortex is critical for memory retrieval and resolving interference

et al. 2013

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The prefrontal cortex (PFC) is known to be critically involved in strategy switching, attentional set shifting, and inhibition of prepotent responses. A central feature of this kind of behavioral flexibility is the ability to resolve conflicting response tendencies, suggesting a general role of the PFC in resolving interference. If so, the PFC should also be involved in memory retrieval, which involves competition between potential retrieval targets. Moreover, the PFC should be needed whenever interference is high, regardless of the strategic or attentional requirements of the task. To test this hypothesis, we temporarily inactivated the mPFC with muscimol and tested rats on several olfactory learning tasks. Rats given muscimol were able to learn a few discrimination problems when they were learned one at a time. However, they were severely impaired when they had to learn and remember many odors concurrently. Rats given muscimol also suffered greater interference when learning two lists of conflicting odor discrimination problems. Additionally, temporary mPFC inactivation during the acquisition of one set of odor memories actually improved the ability to learn a new set of conflicting odor memories. This paradoxical release from interference suggests that the mPFC plays an important role in acquiring and promoting the long term retrieval of memories. These results suggest that the mPFC plays a general role in resolving interference and that this is a key aspect of behavioral flexibility.

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Memory for the Order of Events in Specific Sequences: Contributions of the Hippocampus and Medial Prefrontal Cortex

Cited by 142 publications

References 34 publications

Functional Dissociation of Hippocampal Mechanism during Implicit Learning Based on the Domain of Associations

Functional Dissociation of Hippocampal Mechanism during Implicit Learning Based on the Domain of Associations

Disambiguating past events: Accurate source memory for time and context depends on different retrieval processes

The medial prefrontal cortex is critical for memory retrieval and resolving interference

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