Memory-enhancing activities of the aqueous extract of Albizia adianthifolia leaves in the 6-hydroxydopamine-lesion rodent model of Parkinson’s disease

Abstract

BackgroundAlbizia adianthifolia (Schumach.) W. Wright (Fabaceae) is a traditional herb largely used in the African traditional medicine as analgesic, purgative, anti-inflammatory, antioxidant, antimicrobial and memory-enhancer drug. This study was undertaken in order to evaluate the possible cognitive-enhancing and antioxidative effects of the aqueous extract of A. adianthifolia leaves in the 6-hydroxydopamine-lesion rodent model of Parkinson’s disease.MethodsThe effect of the aqueous extract of A. adianthifolia leaves (150 and 300 mg/kg, orally, daily, for 21 days) on spatial memory performance was assessed using Y-maze and radial arm-maze tasks, as animal models of spatial memory. Pergolide - induced rotational behavior test was employed to validate unilateral damage to dopamine nigrostriatal neurons. Also, in vitro antioxidant activity was assessed through the estimation of total flavonoid and total phenolic contents along with determination of free radical scavenging activity. Statistical analyses were performed using two-way analysis of variance (ANOVA). Significant differences were determined by Tukey’s post hoc test. F values for which p < 0.05 were regarded as statistically significant. Pearson’s correlation coefficient and regression analysis were used in order to evaluate the association between behavioral parameters and net rotations in rotational behavior test.ResultsThe 6-OHDA-treated rats exhibited the following: decrease of spontaneous alternations percentage within Y-maze task and increase of working memory errors and reference memory errors within radial arm maze task. Administration of the aqueous extract of A. adianthifolia leaves significantly improved these parameters, suggesting positive effects on spatial memory formation. Also, the aqueous extract of A. adianthifolia leaves showed potent in vitro antioxidant activity. Furthermore, in vivo evaluation, the aqueous extract of A. adianthifolia leaves attenuated the contralateral rotational asymmetry observed by pergolide challenge in 6-OHDA-treated rats.ConclusionsTaken together, our results suggest that the aqueous extract of A. adianthifolia leaves possesses antioxidant potential and might provide an opportunity for management neurological abnormalities in Parkinson’s disease conditions.

Evaluation of neuropharmacological effects of aqueous leaf extract of Albizia glaberrima (Leguminosae) in mice

“…Aurantiamide acetate and various extracts of Albizia species have been reported to possess strong antioxidant activity with these plant extracts reported to be good sources of natural antioxidants able to prevent the progression of various oxidative stresses (Beppe et al, 2014;Kokila et al, 2013) associated with some CNS disorders. Beppe et al (2014) reported that the aqueous leaf extract of A. adianthifolia possess memoryenhancing effects linked with antioxidant activities in the 6-OHDA (6-hydroxydopamine)-lesion rodent model of Parkinson's disease.…”

The Role of Reactive Oxygen Species in the Pathogenesis of Alzheimer’s Disease, Parkinson’s Disease, and Huntington’s Disease: A Mini Review

“…Pérez-Barrón et al [122] explored the antioxidant and neuroprotective effect of Buddleja cordata methanolic extract in the 1-methyl-4-phenylpyridinium induced PD rat model. Beppe et al [123] suggested that the aqueous extract of Albizia adianthifolia leaves possesses antioxidant potential, which was responsible for the memory-enhancing activities in the rodent model of PD.…”

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“…Beppe et al, 2014 showed that when rats with neurotoxicity induced by 6-hydroxy dopamine injection treated withaqueous extract obtained from Albizia adianthifolia significantly leads to increase of spontaneous alternations percentage, reduction of working memory errors and reference memory errors. Indeed, it had good effect to improve spatial memory 35 .…”