Memory Enhancement by Anticholinesterase as a Function of Initial Learning

Influence of physostigmine upon consolidation of memory in mice.

“…The results reported here are similar to those reported by Squire (1970), who used mice and a similar task and training criterion in research supporting Deutsch's hypothesis. The results are consistent with Deutsch's hypothesis, since it also predicts differential drug effects dependent upon the degree of initial training (Deutsch & Lutzky, 1967).…”

Temporal aspects of anticholinergic- and anticholinesterase-induced amnesia for an appetitive habit.

“…Drug treatment 7 to 14 days after training produced complete or near complete amnesia for the habit. It has also been found that DFP produced good recall for an otherwise forgotten shock escape habit (Deutsch & Leibowitz, 1966) and facilitation of an underlearned habit (Deutsch & Lutzky, 1967).…”

The Cholinergic Synapse and the Site of Memory

“…Three experiments (Deutsch & Leibowitz, unpublished;Deutsch & Lutzky, 1967;Leibowitz, Deutsch, & Coons, unpublished) show a large and unequivocal effect. Rather, the opposite should be the case.…”