Memory disorders in probable Alzheimer's disease: the role of hippocampal atrophy as shown with MRI.

Deweer, Bernard; Lehericy, Stéphane; Pillon, B.; Baulac, Michel; Chiras, J.; Marsault, C.; Agid, Yves; Dubois, Bruno

doi:10.1136/jnnp.58.5.590

Cited by 223 publications

(146 citation statements)

References 39 publications

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“…The current results are consistent with existing literature demonstrating correlations between hippocampal volume loss and a number of visual and verbal performance measures (Cahn et al, 1998;Deweer et al, 1995;Fama et al, 1997;Petersen et al, 2000), including the memory subtests of dementia status tests (Deweer et al, 1995;Fama et al, 1997;Stout et al 1996). Stronger associations have been…”

Section: Discussionsupporting

confidence: 91%

“…Impaired memory function is a critical feature in the diagnostic criteria for probable Alzheimer's disease (McKhann et al, 1984). Hippocampal atrophy in AD, demonstrated with structural MRI, is associated with impaired performance on both verbal and visual memory tasks (Cahn et al, 1998;Deweer et al, 1995;Fama et al, 1997;Petersen et al, 2000), including the memory subtests of dementia status tests (Deweer et al, 1995;Fama et al, 1997;Stout et al 1996). Data from Jernigan's laboratory (Stout et al, 1999) showed significant correlations between the volume of mesial temporal lobe and the immediate recall measures, as well as recognition discriminability, on the California Verbal Learning Test (CVLT; Delis et al, 1987) in demented patients.…”

Section: Introductionmentioning

confidence: 99%

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Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: A structural MRI study

Murphy

Jernigan

Fennema-Notestine

2003

J Int Neuropsychol Soc

119

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The very high sensitivity and specificity of odor identification tasks in discriminating between Alzheimer's patients and normals suggests that they reflect the presence of underlying neuropathology. Significant neuropathological changes are seen in areas critical to processing olfactory information, even in the early stages of Alzheimer's disease (AD). The current study was designed to investigate whether performance on olfactory tasks (odor threshold and odor identification) was related to volumetric MRI measures of mesial temporal areas central to olfactory information processing and important in the neuropathology of AD. Participants were 8 male and 5 female patients with probable AD, and 10 male and 12 female normal age-matched controls, diagnosed at the UCSD Alzheimer's Disease Research Center. The study investigated correlations between volumetric measures of hippocampus, the parahippocampal gyrus and the amygdala, and the psychophysical measures of olfactory function. Robust relationships were observed between mesial temporal lobe volumes and olfactory functional measures. The finding of a strong relationship between left hippocampal volume and performance on the odor identification task (r 5 .85) is compatible with a left-hemisphere superiority for verbally mediated olfactory tasks. The findings suggest a neural substrate for the breakdown in functional performance on verbally mediated odor identification tasks in Alzheimer's disease and suggest the utility of quantitative MRI measures and psychophysical performance in the assessment of AD. These results support the potential clinical utility of inclusion of odor identification tests in diagnostic batteries for detecting AD. (JINS, 2003, 9, 459-471.)

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Left hippocampal volume loss in Alzheimer's disease is reflected in performance on odor identification: A structural MRI study

Murphy

Jernigan

Fennema-Notestine

2003

J Int Neuropsychol Soc

119

View full text Add to dashboard Cite

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“…Response bias and discriminability are two measures derived from recognition memory tasks that are useful in understanding the cognitive systems and therefore the neuroanatomical substrates that underlie memory. Discriminability refers to performance accuracy and reflects the strength of a memory trace, suggesting medial temporal lobe (MTL) recruitment (Deweer et al, 1995). Memory as measured by recall or recognition has been associated with the MTL (Johnson et al, 2001) and therefore discriminability has been the primary focus in most studies of recognition memory.…”

Section: Introductionmentioning

confidence: 99%

Response bias and aging on a recognition memory task

Huh

Kramer

Gazzaley

et al. 2006

J Int Neuropsychol Soc

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Response bias reflects the decision rule an individual uses when faced with uncertainty on recognition memory tasks. Recent studies indicate frontal regions may mediate response bias performance. One theory of aging also implicates frontal lobe contributions in age-related cognitive changes. This suggests that frontal lobe changes may mediate response bias in older adults. Consistent with this frontal aging hypothesis, we predicted that response bias would become more liberal with age. Methods: Participants were 181 younger (30-49) and 112 older normal adults (751) that were part of the California Verbal Learning Test-second edition (CVLT-2) normative sample (total n 5 1078). We used parametric measures of discriminability and response bias provided by the CVLT-2 scoring program. Groups were similar in IQ and education. Multi-level regression models were created to examine the effects of moderating variables. The interaction between age and age group significantly predicted response bias. Post hoc analysis indicated that increasing age was associated with more liberal bias in the older but not in the younger group. In the light of reported relationships between frontal regions and both aging and response bias, we hypothesize that frontal changes may be the underlying mechanism explaining the increase in liberal response bias with age. (JINS, 2006, 12, 1-7.)

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“…Cognitive deficits, in particular of memory, are associated with atrophy of the MTL in AD as revealed by CT (9) or MRI (10). This association is specific because deficits in verbal memory correlate with atrophy of the left hippocampus and deficits in the nonverbal memory correlate with atrophy of the right hippocampus (11,12).…”

mentioning

confidence: 99%